Circadian regulation of glucose, lipid, and energy metabolism in humans.

The circadian system orchestrates metabolism in daily 24-hour cycles. Such rhythms organize metabolism by temporally separating opposing metabolic processes and by anticipating recurring feeding-fasting cycles to increase metabolic efficiency. Although animal studies demonstrate that the circadian system plays a pervasive role in regulating metabolism, it is unclear how, and to what degree, circadian research in rodents translates into humans. Here, we review evidence that the circadian system regulates glucose, lipid, and energy metabolism in humans. Using a range of experimental protocols, studies in humans report circadian rhythms in glucose, insulin, glucose tolerance, lipid levels, energy expenditure, and appetite. Several of these rhythms peak in the biological morning or around noon, implicating earlier in the daytime is optimal for food intake. Importantly, disruptions in these rhythms impair metabolism and influence the pathogenesis of metabolic diseases. We therefore also review evidence that circadian misalignment induced by mistimed light exposure, sleep, or food intake adversely affects metabolic health in humans. These interconnections among the circadian system, metabolism, and behavior underscore the importance of chronobiology for preventing and treating type 2 diabetes, obesity, and hyperlipidemia

Accessing International Capital: Pakistan’s Experience, Prospects, and Policy Implications

In the 1990s accessing international capital markets has become a major source of external financing for many developing countries. The paper reviews Pakistan’s experience in tapping the global financial markets. We conduct a cross-sectional econometric analysis of the factors influencing the access to international equity and debt capital. Results indicate that the factors as suggested in the earlier literature do appear to be influential in determining the access to international capital. The study finds that the role of credit rating in attracting debt flows and of the local capital markets in attracting equity flows is prominent. The rate of economic growth is a major determinant of the access to foreign debt and equity funds. It also appears that the country rating which is based on a comprehensive set of variables indicating the financial health of the country subsumes the other proxies of economic stability and debt management. This study underscores the importance of institutional factors. Areas where improvement is possible to facilitate access to the international capital markets are identified as (1) political and legal environment, including improvements in the quality of the system of civil laws and its enforcement (2) private sector development through sustaining economic liberalisation and privatisation programmes (3) improvement in macro-economic management through a prudent internal and external debt management (4) development of capital markets through, improvements in market operations, enforcement of market regulations, strengthening of financial institutions and effective dissemination of market information.

Towards Global Knowledge Society: A SWOT Analysis of Pakistan Higher Education in Context of Internationalization

Internationalization has emerged as one of the central issues of higher education in the global knowledge economy. Developing countries like Pakistan are in the struggle to develop their higher education system in the globalized means to survive in the 21st fast pace global competitive industry. The efforts of Higher Education Commission (HEC) of Pakistan towards evolving international education settings are appreciable but still there is a need to identify basic mechanism and practices through which transformation of higher education to internationalization is possible. Current study is an overview of the trends of higher education globally, within Asia Pacific Region and specially in Pakistan. The aim of the study is to highlights the strengths and opportunities as well as weakness and threads of Pakistan’s higher education system by proposing a SWOT analysis of higher education internationalization. Pakistan is facing a number of challenges on the way towards globalization and modernization of educational institutes. The study highlights those issues and challenges and suggest a set of practical recommendations to speed up the internationalization process. Keywords: Internationalization, higher education, student mobility, globalizatio

Antibiotic stewardship in community pharmacies a scoping review

The increase in antibiotic resistance has frequently been linked to unrestrained antibiotic dispensing. This review was conducted to mainly assess the perception and attitudes of community pharmacists towards antibiotic dispensing. This scoping review was performed between June 2016 and September 2016 to identify published studies related to the perception and attitudes of community pharmacists towards antibiotic dispensing. The combination of terms such as ‘antibiotic dispensing’, ‘antimicrobial resistance’, ‘community pharmacy’, and ‘community pharmacists’ were searched in electronic databases such as PubMed, ProQuest, Google Scholar, and Science Direct. Only published articles within the last 12 years were included. A total of 13 studies were identified. In general, community pharmacists have good awareness and knowledge of antibiotic dispensing. However, the majority of them are still selling antibiotics to their customers and/or patients for unjustified reasons. The community pharmacists seem well aware of the antimicrobial resistance crisis and considered it a significant health issue. However, many embraced the concept that dispensing antibiotics without medical prescription (DAwMP) can be one of the key features in the dissemination of multidrug resistant bacteria

Cholesterol-cholate-butterfat diet offers multi-organ dysfunction in rats

Background: Comparable to commercial expensive high-fat diets, cholesterol-cholate-butterfat (CCB) diet has also been used to induce hyperlipidemia in rats. Our objective was to explore its influence on multiple organs. Consequence of fasting was also analysed.Methods: Rats in groups 1 and 2 received normal diet (ND) whereas groups 3 and 4 received CCB-diet. Food was withdrawn daily for two hours from groups 2 (ND-F) and 4 (CCB-F). Blood was collected at fourth and sixth week for biochemical estimation; Morris water maze was done in the sixth week for learning ability and memory; after which aortae were isolated for vascular reactivity.Results: Apart from hyperlipidemia, CCB also induced hyperglycemia with marked increase in hepatic enzymes: gamma-glutamyl transferase (GGT), alanine and aspartate aminotransferase (ALT and AST); and vascular biomarkers: uric acid (UA), phosphorus and alkaline phosphatase (ALP). Isolated aortae, pre-contracted with phenylephrine, were less responsive to acetylcholine indicating endothelial dysfunction--serum nitric oxide (NO) production was limited with subsequent inhibition of endothelial NO synthase. CCB diet also compromised learning ability. CCB-coupled fasting potentiated hyperlipidemia but prevented memory-loss.Conclusion: We introduce CCB-diet for multi-organ dysfunction in rats, and propose its use for research on cardiovascular diseases and associated manifestations involving immense interplay of integrated pathways

Comparison of direct shear and triaxial tests for measurement of shear strength of sand

1991 Spring.Includes bibliographic references (pages 103-104).To ascertain the shear strength parameters of soils for engineering purposes is fundamental to soil mechanics and basic for designing earth-bearing and earth-retaining structures. Direct shear and triaxial tests are the most popular laboratory methods to determine these parameters. The direct shear test is used widely because it is simple and quick. The test has several disadvantages, however. The non-uniform stress-strain behavior, the rotation of principal planes during the test, and the imposition of the failure plane are chief among them. The triaxial test was designed as a possible alternative that eliminates some of these disadvantages. Direct shear test results are always comparable to those of the triaxial test; the difference usually is negligible from a practical point of view. Researchers have tried to unfold the intricacies involved in the direct shear test especially the complicated stress-strain behavior that a soil experiences during this test. Data, however, are lacking that determine the difference and establish a correlation between the results of the two tests. This study compares the two tests for measurement of shear strength parameters of sand. Triaxial and direct shear tests were performed on silica sand under the same density and normal stress conditions. Five sets of triaxial tests and 20 direct shear tests each were performed using four different makes of direct shear machines. The results of the direct shear tests were compared with those of the triaxial tests considering the latter as benchmarks. The possible effect of the structural features of the direct shear equipment on results was briefly studied. The results showed that the shear strengths from direct shear tests are higher than those from the triaxial tests. All four direct shear machines gave cohesion values different from each other and higher than the benchmark value. The Soiltest and Wykeham Farrance machines gave almost the same friction angle that was higher than the benchmark value by 4 degrees. The friction angle value from the ELE machine was higher by 2.7 degrees while those from Clockhouse machine were lower by 4.5 degrees as compared to the benchmark value