Spatial knowledge management and participatory governance: rethinking the trajectories of urban, socio-economic and environmental change and the politics of 'sustainability' in southern cities

This paper presents the analytical framework developed iteratively by the research team of the Chance2Sustain (C2S) research project between 2010 and July 2014, in order to answer the main research question which was posed at the outset of the research, namely : how can spatial knowledge management (SKM) and participatory governance contribute to sustainable urban development ? To answer this question, the C2S project was designed to undertake comparative empirical research in 10 cities in four fast-growing countries of the South to understand the role of SKM and participatory processes in facing the challenges in a number of strategic domains of urban development ; those of economic growth, social inequality and vulnerability, and environmental governance. In each city, there were researchers from both the North and South working together in the five domains of economic growth through megaprojects ; social mobilisation and social exclusion in sub-standard settlements ; environmental governance with the focus on water-related issues ; spatial knowledge management; and fiscal decentralisation and participatory city budgeting

Brown Dwarfs in the Pleiades Cluster. III. A deep IZ survey

We present the results of a deep CCD-based IZ photometric survey of a ~1 sq. deg area in the central region of the Pleiades Galactic open cluster. The magnitude coverage of our survey (from I~17.5 down to 22) allows us to detect substellar candidates with masses between 0.075 and 0.03 Msol. Details of the photometric reduction and selection criteria are given. Finder charts prepared from the I-band images are provided.Comment: 11 pages with 8 figures, 4 of them are finder charts given in gif format. Accepted for publication in A&AS. Also available at http://www.iac.es/publicaciones/preprints.htm

Ideologies of time: How elite corporate actors engage the future

Our paper deals with how elite corporate actors in a Western capitalist-democratic society conceive of and prepare for the future. Paying attention to how senior officers of ten important Danish companies make sense of the future will help us to identify how particular temporal narratives are ideologically marked. This ideological dimension offers a common sense frame that is structured around a perceived inevitability of capitalism, a market economy as the basic organizational structure of the social and economic order, and an assumption of confident access to the future. Managers envisage their organization?s future and make plans for organizational action in a space where ?business as usual? reigns, and there is little engagement with the future as fundamentally open; as a time-yet-to-come. In using a conceptual lens inspired by the work of Fredric Jameson, we first explore the details of this presentism and a particular colonization of the future, and then linger over small disruptions in the narratives of our interviewees which point to what escapes or jars their common sense frame, explore the implicit meanings they assign to their agency, and also find clues and traces of temporal actions and strategies in their narratives that point to a subtly different engagement with time

Impact of elosulfase alfa in patients with morquio A syndrome who have limited ambulation: An open-label, phase 2 study.

Efficacy and safety of elosulfase alfa enzyme replacement therapy (ERT) were assessed in an open-label, phase 2, multi-national study in Morquio A patients aged ≥5 years unable to walk ≥30 meters in the 6-min walk test. Patients received elosulfase alfa 2.0 mg/kg/week intravenously for 48 weeks. Efficacy measures were functional dexterity, pinch/grip strength, mobility in a modified timed 25-foot walk, pain, quality of life, respiratory function, and urine keratan sulfate (KS). Safety/tolerability was also assessed. Fifteen patients received elosulfase alfa, three patients discontinued ERT due to adverse events (two were grade 3 drug-related adverse events, the other was not drug-related), and two patients missed >20% of planned infusions; 10 completed treatment through 48 weeks and received ≥80% of planned infusions (Modified Per Protocol [MPP] population). The study population had more advanced disease than that enrolled in other trials. From baseline to week 48, MPP data showed biochemical efficacy (urine KS decreased 52.4%). The remaining efficacy results were highly variable due to challenges in test execution because of severe skeletal and joint abnormalities, small sample sizes, and clinical heterogeneity among patients. Eight patients showed improvements in one or more outcome measures; several patients indicated improvements not captured by the study assessments (e.g., increased energy, functional ability). The nature of adverse events was similar to other elosulfase alfa studies. This study illustrates the considerable challenges in objectively measuring impact of ERT in very disabled Morquio A patients and highlights the need to examine results on an individual basis. © 2016 The Authors. American Journal of Medical Genetics Part A Published by Wiley Periodicals, Inc

Book Review: 1199: Of fiction and finance

Review of Daniel Defoe and the Bank of England: The Dark Arts of Projectors by Valerie Hamilton & Martin Parker. Zero Books, 2016, ISBN 9781782799528. Pages: 189. £11.99 (pbk

Inflammatory bowel disease in Cape Town, 1975-1980 Part I. Ulcerative colitis

Previously documented and new patients with ulcerative colitis seen between 1975 and 1980 in the Gastro-intestinal Clinic of Groote Schuur Hospital were studied to establish the local incidence and clinical features of tHis disease. There were 220 patients and the mean follow-up was 7,7 ± 0,4 years. Sixty percent of patients were White, 37% Coloured and 3% Black. The incidence for the Coloured and White population was calculated' to be 1,3 and 2,4/100000 per year during 1970-1974 and 1,6 and 2,1/100000per year during 1975-1980. respectively. In Jews the rates were 8.5 and 10.4/100 000 per year for the two periods. Insufficient data are available to calculate an incidence for the Black population. The disease was limited to less than 15 cm above the anus in 14% of patients, to the rectoSigmoid colon in 45%. and to the rest of the colon in 40%. Although the severity of symptoms was related to the extent of disease, 22% of patients with extensive colitis had mild symptoms, while 15% with disease limited to the rectum had severe symptoms. The clinical features were similar in the White and Coloured population groups. A total colectomy was performed on 20% of patients with extensive colitis; in 2%the diseasewas complicated by colonic-carcinom

The Substellar Mass Function in sigma Orionis

We combine results from imaging searches for substellar objects in the sigma Orionis cluster and follow-up photometric and spectroscopic observations to derive a census of the brown dwarf population in a region of 847 arcmin^2. We identify 64 very low-mass cluster member candidates in this region. We have available three color (IZJ) photometry for all of them, spectra for 9 objects, and K photometry for 27% of our sample. These data provide a well defined sequence in the I vs I-J, I-K color magnitude diagrams, and indicate that the cluster is affected by little reddening despite its young age (~5 Myr). Using state-of-the-art evolutionary models, we derive a mass function from the low-mass stars (0.2 Msol) across the complete brown dwarf domain (0.075 Msol to 0.013 Msol), and into the realm of free-floating planetary-mass objects (<0.013 Msol). We find that the mass spectrum (dN/dm ~ m^{-alpha}) increases toward lower masses with an exponent alpha = 0.8+/-0.4. Our results suggest that planetary-mass isolated objects could be as common as brown dwarfs; both kinds of objects together would be as numerous as stars in the cluster. If the distribution of stellar and substellar masses in sigma Orionis is representative of the Galactic disk, older and much lower luminosity free-floating planetary-mass objects with masses down to about 0.005 Msol should be abundant in the solar vicinity, with a density similar to M-type stars.Comment: Accepted for publication in ApJ. 19 pages, 3 figures include