Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice

Small body size has been associated with long life span in four stocks of mutant dwarf mice, and in two varieties of dietary restriction in rodents. In this study, small body size at ages 2–24 months was shown to be a significant predictor of life span in a genetically heterogeneous mouse population derived from four common inbred mouse strains. The association was strongest for weights measured early in adult life, and somewhat weaker, though still statistically significant, at later ages. The effect was seen both in males and females, and was replicated in an independent population of the same genetic background. Body size at ages 2–4 months was correlated with levels of serum leptin in both males and females, and with levels of IGF-I and thyroid hormone in females only. A genome scan showed the presence of polymorphic alleles on chromosomes 2, 6, 7 and 15 with significant effects on body weight at 2–4 months, at 10–12 months, or at both age ranges, showing that weight gain trajectory in this stock is under complex genetic control. Because it provides the earliest known predictor of life span, body weight may be usefully included in screens for induced mutations that alter aging. The evidence that weight in 2-month-old mice is a significant predictor of life span suggests that at least some of the lethal diseases of old age can be timed by factors that influence growth rate in juvenile rodents.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75162/1/j.1474-9728.2002.00006.x.pd

Potential uses of health promotion competencies

Projects in Australia and internationally over the past two decades have sought to define and clarify competencies required to work in health promotion. It is now apparent that such competencies are very useful to health promotion practice. However, to date little attempt has been made to describe those uses.More than 200 health promotion practitioners throughout Australia were engaged in workshops to explore and define potential uses of health promotion competencies. The suggestions from these 10 workshops are summarised in eight categories of uses.Agreed health promotion competencies have potential to impact on recruitment, training, employment policy and health promotion practice

A Ransomware Case for Use in the Classroom

Given the global growth in ransomware attacks, employees need to understand the risks of ransomware and how to protect against it. This paper presents a teaching case based on an actual ransomware attack on a hospital that undergraduate or graduate course can use to teach students. The case introduces students to Wildcat Hospital, a fictitious 450-bed acute-care facility in a suburban location in the Northeastern United States. A ransomware attack hit Wildcat Hospital as the workday began. Malware infected the hospital\u27s computers and demanded one bitcoin, a virtual currency that affords anonymity, as ransom to restore functionality of the information systems. The chief executive officer and the chief information officer led the organizational response to the attack. We include links to two videos, a demo of a Locky ransomware attack in action, and a National Broadcasting Company (NBC) TV network news report about a similar ransomware incident at another hospital (Hollywood Presbyterian Medical Center in California) to engage students

Core health promotion competencies for Australia 2007

Four hundred health promotion practitioners throughout Australian completed an on-line survey on Health Promotion Competencies for Australia at the end of 2005. This was followed by a series of workshops throughout Australia in 2006 to identify practical uses of the competencies and to determine a set of core competencies of health promotion practice in Australia. Many of the participants requested information about the results of the study. This brief report has been produced to describe the process and the final result. In addition more detailed accounts are contained in two articles that are being prepared for publication

Local variations in spatial synchrony of influenza epidemics

Background: Understanding the mechanism of influenza spread across multiple geographic scales is not complete. While the mechanism of dissemination across regions and states of the United States has been described, understanding the determinants of dissemination between counties has not been elucidated. The paucity of high resolution spatial-temporal influenza incidence data to evaluate disease structure is often not available. Methodology and Findings: We report on the underlying relationship between the spread of influenza and human movement between counties of one state. Significant synchrony in the timing of epidemics exists across the entire state and decay with distance (regional correlation = 62%). Synchrony as a function of population size display evidence of hierarchical spread with more synchronized epidemics occurring among the most populated counties. A gravity model describing movement between two populations is a stronger predictor of influenza spread than adult movement to and from workplaces suggesting that non-routine and leisure travel drive local epidemics. Conclusions: These findings highlight the complex nature of influenza spread across multiple geographic scales. © 2012 Stark et al

Price Discovery and the Accuracy of Consolidated Data Feeds in the U.S. Equity Markets

Both the scientific community and the popular press have paid much attention to the speed of the Securities Information Processor, the data feed consolidating all trades and quotes across the US stock market. Rather than the speed of the Securities Information Processor, or SIP, we focus here on its accuracy. Relying on Trade and Quote data, we provide various measures of SIP latency relative to high-speed data feeds between exchanges, known as direct feeds. We use first differences to highlight not only the divergence between the direct feeds and the SIP, but also the fundamental inaccuracy of the SIP. We find that as many as 60 percent or more of trades are reported out of sequence for stocks with high trade volume, therefore skewing simple measures such as returns. While not yet definitive, this analysis supports our preliminary conclusion that the underlying infrastructure of the SIP is currently unable to keep pace with the trading activity in today's stock market.Comment: 18 pages, 20 figures, 2 table

Effectiveness of Short-Term Heat Acclimation on Intermittent Sprint Performance in the Heat with Moderately Trained Males

Purpose: Effectiveness of short-term heat acclimation (STHA), over 5-days (permissive dehydration), on intermittent heat stress test (HST) with males. Methods: Ten, moderately-trained, males (mean [SD]; age 25.6 [8.9] y; stature 180.7 [5.6] cm; body mass 83.2 [10.8] kg; and 45.3 [6.5] mL.kg-1.min-1) participated. The HST was 9 x 5min (45-min) of intermittent exercise based on professional soccer players. One week apart, HST1 vs HST (11.0°C; 50%RH), as a reliability trial and HST3 in 31.0°C; 50%RH were completed. Then 90 min dehydration, STHA (no fluid intake), for 5 consecutive days (39.5oC; 60%RH), using controlled-hyperthermia (~rectal temperature [Tre] 38.5oC). The HST4 within one week after STHA. Blood plasma constituents: percent plasma volume (%PV), aldosterone, total protein, albumin, electrolytes, cortisol and HSP70. Data analysis reported as mean differences with 95% confidence intervals (95%CI) and Cohen’s d effect size. Results: Post STHA, there was a decrease of -0.20 Tre at 45-min in the HST (95%CI -0.40 to -0.05°C; P=0.03; d =-0.56); mean skin temperature (-0.80; -1.30 to -0.30°C; P=0.007; d =-1.46) and mean body temperature (-0.30; -0.50 to -0.10°C, P=0.01; d =-0.75). Cardiac frequency reduced (-3: -5 to -1 b.min-1; P=0.01; d =-0.20) and %PV increased (7.3: 0.9 to 13.7%; P=0.03; d=0.59). Mean Peak Power (MPO) increased (Pd =0.63). Conclusions: Short-term heat acclimation (5-days) with dehydration, using controlled-hyperthermia technique, is effective for physiological adaptations during intermittent exercise in the heat, with moderately trained males

Effectiveness of short-term heat acclimation on intermittent sprint performance in the heat with moderately trained males.

Introduction: Effectiveness of short-term heat acclimation (STHA), over 5-days (permissive dehydration), on intermittent heat stress test (HST) with males. Methods: Ten, moderately-trained, males (mean [SD]; age 25.6 [8.9] y; stature 180.7 [5.6] cm; body mass 83.2 [10.8] kg; and 45.3 [6.5] mL.kg-1.min-1) participated. The HST was 9 x 5min (45-min) of intermittent exercise based on professional soccer players. One week apart, HST1 vs HST (11.0°C; 50%RH), as a reliability trial and HST3 in 31.0°C; 50%RH were completed. Then 90 min dehydration, STHA (no fluid intake), for 5 consecutive days (39.5oC; 60%RH), using controlled-hyperthermia (~rectal temperature [Tre] 38.5oC). The HST4 within one week after STHA. Blood plasma constituents: percent plasma volume (%PV), aldosterone, total protein, albumin, electrolytes, cortisol and HSP70. Data analysis reported as mean differences with 95% confidence intervals (95%CI) and Cohen’s d effect size. Results: Post STHA, there was a decrease of -0.20 Tre at 45-min in the HST (95%CI -0.40 to -0.05°C; P=0.03; d =-0.56); mean skin temperature (-0.80; -1.30 to -0.30°C; P=0.007; d =-1.46) and mean body temperature (-0.30; -0.50 to -0.10°C, P=0.01; d =-0.75). Cardiac frequency reduced (-3: -5 to -1 b.min-1; P=0.01; d =-0.20) and %PV increased (7.3: 0.9 to 13.7%; P=0.03; d=0.59). Mean Peak Power (MPO) increased (P<0.05) across sprints 7, 8 and 9. Time to exhaustion increased (167: -15 to 350 s; P=0.06; d =0.63). Conclusions: Short-term heat acclimation (5-days) with dehydration, using controlled-hyperthermia technique, is effective for physiological adaptations during intermittent exercise in the heat, with moderately-trained males