The acute and chronic effects of cigarette smoking upon various aspects of gastric secretion

This study examined the inter-relationship between cigarette smoking (acute and chronic) on the one hand and gastric acid secretion, duodenogastric reflux and pyloric loss on the other. Using gastric intubation and a histamine secretogogue, pure gastric secretion (Vg), pyloric loss (PL) and duodenogastric reflux (DGR) were measured in smokers and non-smokers with and without duodenal ulcer disease. The subjects were studied at basal, 1/8th maximal, 1/4 maximal and maximal stimulation. Acute cigarette smoking significantly reduced Vg in both controls (C) (n = 8) and duodenal ulcer subjects (DU) (n = 14); there was no change in either pyloric loss or duodenogastric reflux. The fall in Vg coincided with the period in which there is known to be a rise in the plasma levels of toxic tobacco products. In both groups of chronic smokers (C, n = 68; DU, n = 177) maximal Vg was significantly greater than in non-smokers (C, n = 46; DU, n = 36). Under basal conditions Vg was lower in the smokers (C, n = 25; DU, n = 91) compared to non-smokers (C, n = 20; DU, n = 15) but this did not reach significance. The rate of pyloric loss was constant in any one individual, independent of secretory or clinical state. However, pyloric loss was higher in those with a greater secretory capacity: namely, smokers and duodenal ulcer patients. Duodenogastric reflux was greatest under basal conditions and significantly reduced at maximal stimulation, this was true for both groups (C & DU). This was thought to represent increased activity of the pylorus under conditions of maximal stimulation. Duodenogastric reflux was greater in those with duodenal ulcers compared to controls at both basal and maximal secretion. Analysis showed that this difference may in part reflect the disease process. Chronic cigarette smoking had no direct effect on pyloric loss or duodenogastric reflux, any effect there was, was mediated through changes in secretory capacity. Dose-response analysis revealed no evidence of increased sensitivity of the parietal cells in either duodenal ulcer patients or chronic smokers. The increased secretory capacities of these groups is simply due to an increased parietal cell mass. It is suggested that the toxic products of tobacco smoke cause an acute reduction in Vg which eventually leads to an increase in parietal cell mass and hence Vg

Urban world: Mapping the economic power of cities

Until now, a lack of global data at the city level has prevented companies and policymakers from tracking the evolving role of cities in the global economy and positioning their business and policy activities accordingly. To help close this "white space" in our understanding of the global economy, the McKinsey Global Institute (MGI), McKinsey & Company's business and economics research arm, has built on its extensive body of research on the urbanization of China, India, and Latin America to develop the MGI Cityscope, a database of more than 2,000 metropolitan areas around the world that we believe is the largest of its kind. By analyzing demographic, income, and household trends in these cities, the database offers actionable insights on the choices facing companies looking for new markets and policy makers seeking to improve their urban management and the alignment of their diplomatic efforts with their countries' trade interests

Strengths and Weaknesses of National Agricultural Research Systems: Attracting the Next Generation of Grasslands Researchers

In the 1960s and 1970s the world faced up to the poverty and hunger facing a significant proportion of the global population, which at the time was around 4 billion people. The efforts of Norman Borlaug and the Green Revolution resulted in food production increasing as the technologies and knowledge known at the time were directed to that task. The success of the Green Revolution was such that governments and the world communities turned attention to other issues and agricultural development slid down the list of priorities. The world population is now over 7 billion and projected to be over 9 billion by 2050. FAO (2012b) estimates that around 870 million people were under-nourished (in terms of dietary energy supply) in the period 2010–12; one in eight people globally. Food production will need to increase by 50 to 70% by 2050 to meet food security demands and this increase will have to be achieved through productivity gains given the limitation on global productive lands. Food production faces competition from biofuels, mining and urban sprawl for those lands, making productivity gains an even greater imperative

In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study"

No abstract available

Prey and range use of lions on Tswalu Kalahari Reserve

The exact ecological and economic role of lion Panthera leo populations on small enclosed reserves is poorly understood. The management and monitoring of such populations is important to ensure their long-term survival. The prey use, range use and habitat selection of an isolated lion population were investigated. The study was conducted on a small (> 1000km2), enclosed predator camp of Tswalu Kalahari Reserve, situated in the Northern Cape Province of the Republic of South Africa. The prey selection, prey preferences and prey biomass removal were determined by using indirect and direct observations. Kill sites, carcasses and scats were located by spoor tracking and opportunistic observations and collated into a prey selection list. The prey selection was used to determine any prey preferences and the prey biomass removal by the lion population. The scats data was corrected for relative prey biomass and compared to the kill data and uncorrected scat data. 19 prey types were used, with the gemsbok Oryx gazelle and blue wildebeest Connochaetes taurinus being utilized most. The lion population had clear preferences for specific small and large mammals which concurred with other studies done on Kalahari lion behaviour. The prey biomass removal (9.9kg/Lion feeding Unit/day) was higher than several other studies done on lion consumption rates. The range use and habitat selection were determined by using direct and indirect observations. The minimum convex polygon method and kernel density estimates were used to delineate the ranges of the lion population. The mean range size of the Tswalu lions (91 km2) was similar to those found for lions in more mesic environments. The lions also had clear habitat preferences which depended on the habitat preferences of the prey and the prey density. A population viability analysis, using VORTEX 9.72, was conducted. An Ecological capacity was determined and used to model various environmental scenarios. The population was found to be viable, but constant monitoring and updating are needed. Management recommendations for the conservation of lions and their prey are provided.Dissertation (MSc)--University of Pretoria, 2010.Animal and Wildlife Sciencesunrestricte

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer

Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic assessment of the tumor inflammatory cell infiltrate and tumor stroma, in patients with primary operable colorectal cancer. Experimental Design: Using routine pathologic sections, the tumor inflammatory cell infiltrate and stroma were assessed using Klintrup–Mäkinen (KM) grade and tumor stroma percentage (TSP), respectively, in 307 patients who had undergone elective resection for stage I–III colorectal cancer. The clinical utility of a cumulative score based on these characteristics was examined. Results: On univariate analysis, both weak KM grade and high TSP were associated with reduced survival (HR, 2.42; P = 0.001 and HR, 2.05; P = 0.001, respectively). A cumulative score based on these characteristics, the Glasgow Microenvironment Score (GMS), was associated with survival (HR, 1.93; 95% confidence interval, 1.36–2.73; P < 0.001), independent of TNM stage and venous invasion (both P < 0.05). GMS stratified patients in to three prognostic groups: strong KM (GMS = 0), weak KM/low TSP (GMS = 1), and weak KM/high TSP (GMS = 2), with 5-year survival of 89%, 75%, and 51%, respectively (P < 0.001). Furthermore, GMS in combination with node involvement, venous invasion, and mismatch repair status further stratified 5-year survival (92% to 37%, 93% to 27%, and 100% to 37%, respectively). Conclusions: The present study further confirms the clinical utility of assessment of the tumor microenvironment in colorectal cancer and introduces a simple, routinely available prognostic score for the risk stratification of patients with primary operable colorectal cancer

Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host

Purpose: In patients with colorectal cancer (CRC), a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival. One potential unifying mechanism is the IL-6/JAK/STAT3 pathway. The present study examines the relationship between tumour total STAT3 and phosphorylated STAT3Tyr705 (pSTAT3) expression, host inflammatory responses and survival in patients undergoing resection of stage I-III CRC. Experimental Design: Immunohistochemical assessment of STAT3/pSTAT3 expression was performed using a tissue microarray and tumour cell expression divided into tertiles using the weighted histoscore. The relationship between STAT3/pSTAT3 expression and local inflammatory (CD3+, CD8+, CD45R0+, FOXP3+ T-cell density and Klintrup-Mäkinen grade) and systemic inflammatory responses and cancer-specific survival were examined. Results: 196 patients were included in the analysis. Cytoplasmic and nuclear STAT3 expression strongly correlated (r=0.363, P<0.001); nuclear STAT3 and pSTAT3 expression weakly correlated (r=0.130, P=0.068). Cytoplasmic STAT3 was inversely associated with the density of CD3+ (P=0.012), CD8+ (P=0.003) and FOXP3+ T-lymphocytes (P=0.002) within the cancer cell nests and was associated with an elevated systemic inflammatory response as measured by modified Glasgow Prognostic Score (mGPS2: 19% vs. 4%, P=0.004). The combination of nuclear STAT3/pSTAT3 stratified five-year survival from 81% to 62% (P=0.012), however was not associated with survival independent of venous invasion, tumour perforation or tumour budding. Conclusion In patients undergoing CRC resection, STAT3 expression was associated with adverse host inflammatory responses and reduced survival. Up-regulation of tumour STAT3 may be an important mechanism whereby the tumour deregulates local and systemic inflammatory responses

Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer

Background: How systemic inflammation-based prognostic scores such as the modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR) differ across populations of patients with colorectal cancer (CRC) remains unknown. The present study examined the mGPS and NLR in patients from United Kingdom (UK) and Japan. Methods: Patients undergoing resection of TNM I-III CRC in two centres in the UK and Japan were included. Differences in clinicopathological characteristics and mGPS (0-CRP≤10 mg/L, 1-CRP>10 mg/L, 2-CRP>10 mg/L, albumin<35 g/L) and NLR (≤5/>5) were examined. Results: Patients from UK (n = 581) were more likely to be female, high ASA and BMI, present as an emergency (all P < 0.01) and have higher T stage compared to those from Japan (n = 559). After controlling for differences in tumor and host characteristics, patients from Japan were less likely to be systemically inflamed (OR: mGPS: 0.37, 95%CI 0.27–0.50, P < 0.001; NLR: 0.53, 95%CI 0.35–0.79, P = 0.002). Conclusion: Systemic inflammatory responses differ between populations with colorectal cancer. Given their prognostic value, reporting of systemic inflammation-based scores should be incorporated into future studies reporting patient outcomes. Summary: Although the systemic inflammatory response is recognised as a prognostic factor in patients with colorectal cancer, it is not clear how these may differ between distinct geographical populations. The present study examines differences in the prevalence of elevated systemic inflammatory responses (modified Glasgow Prognostic Score and neutrophil:lymphocyte ratio) between two populations undergoing resection of colorectal cancer in the United Kingdom and Japan

Multiple phonetically trained-listener comparisons of speech before and after articulatory intervention in two children with repaired submucous cleft palate

In Cleft Palate (CP) assessments based on phonetic transcription are the gold standard- therapy outcome measure, despite reliability difficulties. Here we propose a novel perceptual evaluation, applied to ultrasound-visual biofeedback (U-VBF) therapy and therapy using visual articulatory models (VAMs) for two children with repaired submucous CP. Three comparisons were made: post VAM, post U-VBF and overall pre- and post-therapy. Twenty-two phonetically-trained listeners were asked to determine whether pre- or post-therapy recordings sounded closer to the English target-, using their own implicit stored knowledge (prompted via orthographic representation) as a comparison. Results are compared with segment-oriented percent target consonant correct (PTCC) derived from phonetic transcriptions by the authors. Listener judgements and PTCC suggest that both children made improvements using both VAM and U-VBF. Statistical analysis showed listener agreement across all three comparisons, despite agreement being poor. This perceptual evaluation offers a straightforward method of evaluating the effectiveness of interventions and can be used by phonetically trained or lay listeners.casl30pub4265pub3-