Estuarine exchange flow quantified with isohaline coordinates : contrasting long and short estuaries

Author Posting. © American Meteorological Society, 2012. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 42 (2012): 748–763, doi:10.1175/JPO-D-11-086.1.Isohaline coordinate analysis is used to compare the exchange flow in two contrasting estuaries, the long (with respect to tidal excursion) Hudson River and the short Merrimack River, using validated numerical models. The isohaline analysis averages fluxes in salinity space rather than in physical space, yielding the isohaline exchange flow that incorporates both subtidal and tidal fluxes and precisely satisfies the Knudsen relation. The isohaline analysis can be consistently applied to both subtidally and tidally dominated estuaries. In the Hudson, the isohaline exchange flow is similar to results from the Eulerian analysis, and the conventional estuarine theory can be used to quantify the salt transport based on scaling with the baroclinic pressure gradient. In the Merrimack, the isohaline exchange flow is much larger than the Eulerian quantity, indicating the dominance of tidal salt flux. The exchange flow does not scale with the baroclinic pressure gradient but rather with tidal volume flux. This tidal exchange is driven by tidal pumping due to the jet–sink flow at the mouth constriction, leading to a linear dependence of exchange flow on tidal volume flux. Finally, a tidal conversion parameter Qin/Qprism, measuring the fraction of tidal inflow Qprism that is converted into net exchange Qin, is proposed to characterize the exchange processes among different systems. It is found that the length scale ratio between tidal excursion and salinity intrusion provides a characteristic to distinguish estuarine regimes.SNC is supported by a WHOI postdoctoral scholarship, a NSF Grant OCE-0926427, and a Taiwan National Science Council Grant NSC 100- 2199-M-002-028.WRGis supported byNSFGrantOCE- 0926427. JAL is supported by NSF Grant OCE-0452054.2012-11-0

The temporal response of the length of a partially stratified estuary to changes in river flow and tidal amplitude

Author Posting. © American Meteorological Society, 2009. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 39 (2009): 915-933, doi:10.1175/2008JPO3933.1.The temporal response of the length of a partially mixed estuary to changes in freshwater discharge Qf and tidal amplitude UT is studied using a 108-day time series collected along the length of the Hudson River estuary in the spring and summer of 2004 and a long-term (13.4 yr) record of Qf, UT, and near-surface salinity. When Qf was moderately high, the tidally averaged length of the estuary L5, here defined as the distance from the mouth to the up-estuary location where the vertically averaged salinity is 5 psu, fluctuated by more than 47 km over the spring–neap cycle, ranging from 28 to >75 km. During low flow periods, L5 varied very little over the spring–neap cycle and approached a steady length. The response is quantified and compared to predictions of a linearized model derived from the global estuarine salt balance. The model is forced by fluctuations in Qf and UT relative to average discharge Qo and tidal amplitude UTo and predicts the linear response time scale τ and the steady-state length Lo for average forcing. Two vertical mixing schemes are considered, in which 1) mixing is proportional to UT and 2) dependence of mixing on stratification is also parameterized. Based on least squares fits between L5 and estuary length predicted by the model, estimated τ varied by an order of magnitude from a period of high average discharge (Qo = 750 m3 s−1, τ = 4.2 days) to a period of low discharge (Qo = 170 m3 s−1, τ = 40.4 days). Over the range of observed discharge, Lo Qo−0.30±0.03, consistent with the theoretical scaling for an estuary whose landward salt flux is driven by vertical estuarine exchange circulation. Estimated τ was proportional to the discharge advection time scale (LoA/Qo, where A is the cross-sectional area of the estuary). However, τ was 3–4 times larger than the theoretical prediction. The model with stratification-dependent mixing predicted variations in L5 with higher skill than the model with mixing proportional to UT. This model provides insight into the time-dependent response of a partially stratified estuary to changes in forcing and explains the strong dependence of the amplitude of the spring–neap response on freshwater discharge. However, the utility of the linear model is limited because it assumes a uniform channel, and because the underlying dynamics are nonlinear, and the forcing Qf and UT can undergo large amplitude variations. River discharge, in particular, can vary by over an order of magnitude over time scales comparable to or shorter than the response time scale of the estuary.This study was generously funded by Hudson River Foundation Grant 005/03A and NSF Grant OCE-0452054. Lerczak also received partial support from the Woods Hole Center for Oceans and Human Health, NSF Grant OCE-0430724 and NIEHS Grant 1-P50-ES012742-01

Wave breaking turbulence at the offshore front of the Columbia River Plume

© The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Geophysical Research Letters 41 (2014): 8987–8993, doi:10.1002/2014GL062274.Observations at the Columbia River plume show that wave breaking is an important source of turbulence at the offshore front, which may contribute to plume mixing. The lateral gradient of current associated with the plume front is sufficient to block (and break) shorter waves. The intense whitecapping that then occurs at the front is a significant source of turbulence, which diffuses downward from the surface according to a scaling determined by the wave height and the gradient of wave energy flux. This process is distinct from the shear-driven mixing that occurs at the interface of river water and ocean water. Observations with and without short waves are examined, especially in two cases in which the background conditions (i.e., tidal flows and river discharge) are otherwise identical.This work was supported by the Office of Naval Research, as part of the Data Assimilation and Remote Sensing for Littoral Applications (DARLA) project and in coordination with the Rivers and Inlets (RIVET) program

On nonhydrostatic coastal model simulations of shear instabilities in a stratified shear flow at high Reynolds number

Author Posting. © American Geophysical Union, 2017. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 122 (2017): 3081–3105, doi:10.1002/2016JC012334.The nonhydrostatic surface and terrain-following coastal model NHWAVE is utilized to simulate a continually forced stratified shear flow in a straight channel, which is a generic problem to test the existing nonhydrostatic coastal models' capability in resolving shear instabilities in the field scale. The resolved shear instabilities in the shear layer has a Reynolds number of about 1.4 × 106, which is comparable to field observed value. Using the standard Smagorinsky closure with a grid size close to the Ozmidov length scale, simulation results show that the resolved energy cascade exceeds 1 order of magnitude and the evolution and turbulent mixing characteristics are predicted well. Two different approaches are used to estimate the turbulent dissipation rate, namely using the resolved turbulent energy spectrum and the parameterized subgrid turbulent dissipation rate, and the predicted results provide the upper and lower bounds that encompass the measured values. Model results show significantly higher turbulence in braids of shear instabilities, which is similar to field observations while both the subgrid turbulent dissipation rate and resolved vorticity field can be used as surrogates for measured high acoustic backscatter signals. Simulation results also reveal that the surface velocity divergence/convergence is an effective identifier for the front of the density current and the shear instabilities. To guide future numerical studies in more realistic domains, an evaluation on the effects of different grid resolutions and subgrid viscosity on the resolved flow field and subgrid dissipation rate are discussed.Office of Naval Research Grant Numbers: N00014-15-1-2612 , N00014-16-1-2948; National Science Foundation Grant Numbers: OCE-1334325 , OCE-1232928; Extreme Science and Engineering Discovery Environment (XSEDE) SuperMIC Grant Number: TG-OCE1000152017-10-1

Thrombopoietin receptor agonist therapy in primary immune thrombocytopenia is associated with bone marrow hypercellularity and mild reticulin fibrosis but not other stromal abnormalities

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A molecular biology and phase II trial of lapatinib in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

High expression of ERBB2 has been reported in medulloblastoma and ependymoma; EGFR is amplified and over-expressed in brainstem glioma suggesting these proteins as potential therapeutic targets. We conducted a molecular biology (MB) and phase II study to estimate inhibition of tumor ERBB signaling and sustained responses by lapatinib in children with recurrent CNS malignancies. In the MB study, patients with recurrent medulloblastoma, ependymoma, and high-grade glioma (HGG) undergoing resection were stratified and randomized to pre-resection treatment with lapatinib 900 mg/m(2) dose bid for 7-14 days or no treatment. Western blot analysis of ERBB expression and pathway activity in fresh tumor obtained at surgery estimated ERBB receptor signaling inhibition in vivo. Drug concentration was simultaneously assessed in tumor and plasma. In the phase II study, patients, stratified by histology, received lapatinib continuously, to assess sustained response. Eight patients, on the MB trial (four medulloblastomas, four ependymomas), received a median of two courses (range 1-6+). No intratumoral target inhibition by lapatinib was noted in any patient. Tumor-to-plasma ratios of lapatinib were 10-20 %. In the 34 patients (14 MB, 10 HGG, 10 ependymoma) in the phase II study, lapatinib was well-tolerated at 900 mg/m(2) dose bid. The median number of courses in the phase II trial was two (range 1-12). Seven patients (three medulloblastoma, four ependymoma) remained on therapy for at least four courses range (4-26). Lapatinib was well-tolerated in children with recurrent or CNS malignancies, but did not inhibit target in tumor and had little single agent activity.Fil: Fouladi, Maryam. St. Jude Children’s Research Hospital; Estados UnidosFil: Stewart, Clinton F.. St. Jude Children’s Research Hospital; Estados UnidosFil: Blaney, Susan M.. Baylor College of Medicine. Texas Children’s Cancer Center; Estados UnidosFil: Onar Thomas, Arzu. St. Jude Children’s Research Hospital; Estados UnidosFil: Schaiquevich, Paula Susana. St. Jude Children’s Research Hospital; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Packer, Roger J.. Children’s National Medical Center; Estados UnidosFil: Goldman, Stewart. Anne and Robert H. Lurie Children’s Hospital of Chicago; Estados UnidosFil: Geyer, J. Rusell. Children’s Hospital and Regional Medical Center; Estados UnidosFil: Gajjar, Amar. St. Jude Children’s Research Hospital; Estados UnidosFil: Kun, Larry E.. St. Jude Children’s Research Hospital; Estados UnidosFil: Boyett, James M.. St. Jude Children’s Research Hospital; Estados UnidosFil: Gilbertson, Richard J.. St. Jude Children’s Research Hospital; Estados Unido

Modeling the Lateral Circulation in Straight, Stratified Estuaries*

The dynamics of lateral circulation in an idealized, straight estuary under varying stratification conditions is investigated using a three-dimensional, hydrostatic, primitive equation model in order to determine the importance of lateral circulation to the momentum budget within the estuary. For all model runs, lateral circulation is about 4 times as strong during flood tides as during ebbs. This flood–ebb asymmetry is due to a feedback between the lateral circulation and the along-channel tidal currents, as well as to time-varying stratification over a tidal cycle. As the stratification is increased, the lateral circulation is significantly reduced because of the adverse pressure gradient set up by isopycnals being tilted by the lateral flow itself. When rotation is included, a timedependent, cross-channel Ekman circulation is driven, and the tidally averaged, bottom lateral circulation is enhanced toward the right bank (when looking toward the ocean in the Northern Hemisphere). This asymmetry in the tidally averaged bottom lateral circulation may lead to asymmetric sediment transport, leading to asymmetric channel profiles in straight estuaries. For the weakly stratified model run, advection due to lateral currents is a dominant term in both the along-channel and cross-channel momentum equations over a tidal cycle and for the tidally averaged momentum equations. In the tidally averaged, along-channel momentum equation, lateral advection acts as a driving term for the estuarine exchange flow and can be larger than the along-channel pressure gradient. Therefore, it should not be ignored when estimating momentum budgets in estuaries

Low-Molecular-Weight Heparin Use in a Case of Noncardiogenic Multifocal Perinatal Thromboembolic Stroke

A full-term neonate suffered multifocal cerebral infarctions due to multiple large vessel thrombi. Thrombophilia and cardiovascular assessments were negative, but due to the severity of the lesions and the concern for expansion of the thrombi or future embolic events, treatment with low-molecular-weight heparin (LMWH) was initiated. No complications from treatment were experienced. We present this severe case in order to highlight difficult management decisions for newborns with multifocal perinatal thromboembolic stroke and to stress the need for further practice guidelines and research in this area

Mechanisms driving the time-dependent salt flux in a partially stratified estuary

Author Posting. © American Meteorological Society, 2006. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 36 (2006): 2296-2311, doi:10.1175/JPO2959.1.The subtidal salt balance and the mechanisms driving the downgradient salt flux in the Hudson River estuary are investigated using measurements from a cross-channel mooring array of current meters, temperature and conductivity sensors, and cross-channel and along-estuary shipboard surveys obtained during the spring of 2002. Steady (subtidal) vertical shear dispersion, resulting from the estuarine exchange flow, was the dominant mechanism driving the downgradient salt flux, and varied by over an order of magnitude over the spring–neap cycle, with maximum values during neap tides and minimum values during spring tides. Corresponding longitudinal dispersion rates were as big as 2500 m2 s−1 during neap tides. The salinity intrusion was not in a steady balance during the study period. During spring tides, the oceanward advective salt flux resulting from the net outflow balanced the time rate of change of salt content landward of the study site, and salt was flushed out of the estuary. During neap tides, the landward steady shear dispersion salt flux exceeded the oceanward advective salt flux, and salt entered the estuary. Factor-of-4 variations in the salt content occurred at the spring–neap time scale and at the time scale of variations in the net outflow. On average, the salt flux resulting from tidal correlations between currents and salinity (tidal oscillatory salt flux) was an order of magnitude smaller than that resulting from steady shear dispersion. During neap tides, this flux was minimal (or slightly countergradient) and was due to correlations between tidal currents and vertical excursions of the halocline. During spring tides, the tidal oscillatory salt flux was driven primarily by oscillatory shear dispersion, with an associated longitudinal dispersion rate of about 130 m2 s−1.This work was supported by National Science Foundation Grant OCE00-95972 and Hudson River Foundation Grant 005/03A. Author Lerczak received partial support from the Penzance Endowed Fund in Support of Assistant Scientists