Supporting data for "KAPow: High-accuracy, Low-overhead Online Per-module Power Estimation for FPGA Designs"

<p>Supporting data for "KAPow: High-accuracy, Low-overhead Online Per-module Power Estimation for FPGA Designs"</p

Additional file 1: of Progression of diabetes, ischemic heart disease, and chronic kidney disease in a three chronic conditions multistate model

State occupation probabilities and transition hazards: A supplementary description of statistical methods used for estimating state occupation probabilities and transition hazards. Table S1. A summary matrix showing state-to-state transition counts for the chronic disease network. NA indicates transitions that are not applicable for the system. Table S2. Estimated regression coefficients that represent effects of covariates: age, gender, race/ethnicity, CCI and dual eligibility, on the state occupation probability at selected time points along with p-values (in brackets). Table S3. Estimated regression coefficients that represent effects of covariates: age, gender, race/ethnicity, CCI and dual eligibility, on cumulative transition hazards at selected time points along with p-values (in brackets). Figure S1. Marginally estimated cumulative state-to-state transition hazards from state DM to subsequent states. Figure S2. Marginally estimated cumulative state-to-state transition hazards from state IHD to subsequent states along with bootstrap based 95% point-wise confidence bands. Figure S3. Marginally estimated cumulative state-to-state transition hazards from state CKD to subsequent states along with bootstrap based 95% point-wise confidence bands. Figure S4. Marginally estimated cumulative state-to-state transition hazards from state DM+HD to subsequent states along with bootstrap based 95% point-wise confidence bands. Figure S5. Marginally estimated cumulative state-to-state transition hazards from state DM+CKD to subsequent states along with bootstrap based 95% point-wise confidence bands. Figure S6. Marginally estimated cumulative state-to-state transition hazards from state IHD+CKD to subsequent states along with bootstrap based 95% point-wise confidence bands. Figure S7. Marginally estimated state cumulative state-to-state transition hazards form state DM+IHD+CKD to Death state along with bootstrap based 95% point-wise confidence bands. (PDF 406 kb

Oxidative Uranium Release from Anoxic Sediments under Diffusion-Limited Conditions

Uranium (U) contamination occurs as a result of mining and ore processing; often in alluvial aquifers that contain organic-rich, reduced sediments that accumulate tetravalent U, U­(IV). Uranium­(IV) is sparingly soluble, but may be mobilized upon exposure to nitrate (NO₃^–) and oxygen (O₂), which become elevated in groundwater due to seasonal fluctuations in the water table. The extent to which oxidative U mobilization can occur depends upon the transport properties of the sediments, the rate of U­(IV) oxidation, and the availability of inorganic reductants and organic electron donors that consume oxidants. We investigated the processes governing U release upon exposure of reduced sediments to artificial groundwater containing O₂ or NO₃^– under diffusion-limited conditions. Little U was mobilized during the 85-day reaction, despite rapid diffusion of groundwater within the sediments and the presence of nonuraninite U­(IV) species. The production of ferrous iron and sulfide in conjunction with rapid oxidant consumption suggested that the sediments harbored large concentrations of bioavailable organic carbon that fueled anaerobic microbial respiration and stabilized U­(IV). Our results suggest that seasonal influxes of O₂ and NO₃^– may cause only localized mobilization of U without leading to export of U from the reducing sediments when ample organic carbon is present

Additional file 1: Appendix 1. of Giving formulary and drug cost information to providers and impact on medication cost and use: a longitudinal non-randomized study

BASELINE medication use and cost in 2007 – Means and standard deviations. Baseline medication use and cost of patients’ prescription drugs in 2007. Appendix 1 is the same as Table 1 in the manuscript, but includes the standard deviations. Appendix 2. FOLLOW-UP medication use and cost in 2009 – Means and standard deviations. Follow-up medication use and cost of patients’ prescription drugs in 2009. Appendix 2 is the same as Table 2 in the manuscript, but includes the standard deviations. Appendix 3. CHANGE in medication use and cost from BASELINE to FOLLOW-UP year – Means and standard deviations. Change in medication use and cost of patients’ prescription drugs from 2007 to 2009. Appendix 3 is the same as Table 3 in the manuscript, but includes the standard deviations. (DOCX 22 kb

Additional file 1: of Cardiovascular care guideline implementation in community health centers in Oregon: a mixed-methods analysis of real-world barriers and challenges

Appendix A. Publications: The Evidence Behind the ALL Initiative Medications (DOC 29 kb)

DataSheet_1_Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy.docx

IntroductionPost translational modification of proteins plays a significant role in immune recognition. In particular the modification of arginine to citrulline which is mediated by PAD enzymes is increased during cellular stress (autophagy) which permits the presentation of modified epitopes upon MHC class II molecules for recognition by CD4 T cells. Citrullination also occurs in tumour cells as a result of continuous environmental stresses and increased autophagy. We have shown in animal models the efficient stimulation of citrullinated epitope specific CD4 T cells resulting in dramatic elimination/regression of tumours. The ER chaperone glucose-regulated protein 78 (GRP78) is known to also be required for stress-induced autophagy and is directly linked to autophagosome formation. GRP78 is known to be highly expressed by many tumour types. In this study we investigate the potential of targeting citrullinated GRP78 for cancer therapy.MethodsA citrullinated GRP78 specific antibody was used to assess citrullinated GRP78 expression in murine and human tumour cells by flow cytometry. Five peptides were selected and used to vaccinate HLA transgenic mice and immune responses were characterised by ex vivo cytokine ELISpot assay. T cell repertoire in humans was assessed through proliferation assays and cytokine ELISpot assay. Citrullinated peptide was identified in murine B16 melanoma by mass spectrometry and the peptide vaccine was assessed for tumour therapy in a mouse melanoma model.ResultsWe show the identification CD4 T cell responses to one citrullinated GRP78 epitope that are restricted through HLA DP*0401 and HLA-DR*0101 alleles. This peptide is detected by mass spectrometry in B16 melanoma grown in vivo and citrulline specific CD4 responses to two peptides spanning this epitope mediate efficient therapy of established B16 melanoma tumours in HHDII/DP4 (pConclusionWe propose that citrullinated GRP78 is a candidate tumour antigen and vaccination against citrullinated GRP78 may provide a promising tumour therapy approach.</p