The investigation of fibre reinforcement effects in thermoplastic materials: interfacial bond strength and fibre end parameter

Glass fibres used in the manufacture of fibre reinforced thermoplastic composites (FRTP) are normally sized with a film former which includes a silane coupling agent to improve the interfacial bond strength between glass fibre and matrix . However, during composite failure even an optimized interface cannot stop the initia tion of cracks at the fibre ends, which can lead to large transverse cracks in the matrix or failure by fibre pull-out. In order to help better understand the failure mechanisms of FRTP, thermoplastic microbond tests and photoelasticity experiments have been used to study the interface in model single fibre composites

Novel strategies for transition metal catalysis in living cells

The ability to carry out efficient transition metal catalysis inside living cells has the potential to unlock a diverse range of new-to-nature transformations, and provides the opportunity to gain insight into the working of biological systems by providing new routes towards biomolecular labelling and imaging, as well as to specific and controlled prodrug activation. However, there is often poor biocompatibility of metal catalyst with the cellular environment. The irreversible poisoning of metal catalysts by biomolecules, in particular intracellular thiols, results in deactivated complexes which are no longer catalytically active. Another hurdle is that very low catalyst concentrations and loadings are required to circumvent cytotoxicity induced by the metal complex. Together, this has the result that the majority of transition metal catalysed reactions carried out in living cells exhibit very poor catalytic activity, with low turnover numbers and low yields. Therefore, it is apparent that new strategies need to be developed in order to make progress towards achieving efficient in vivo transition metal catalysis. In this thesis we present two new strategies to improve the reactivity of transition metal catalysts under biological conditions. Firstly, encapsulation of a gold catalyst within the cavity a supramolecular cage protects the catalyst by providing a physical barrier which can hinder large biomolecules from reaching the metal centre. The second strategy is kinetic protection. Increasing the reaction kinetics of a metathesis catalyst allows productive catalysis to occur faster than catalyst decomposition pathways, and therefore improving the yield of catalysis in the presence of biological poisons

Transition Metal Catalysis in Living Cells:Progress, Challenges, and Novel Supramolecular Solutions

The importance of transition metal catalysis is exemplified by its wide range of applications, for example in the synthesis of chemicals, natural products, and pharmaceuticals. However, one relatively new application is for carrying out new-to-nature reactions inside living cells. The complex environment of a living cell is not welcoming to transition metal catalysts, as a diverse range of biological components have the potential to inhibit or deactivate the catalyst. Here we review the current progress in the field of transition metal catalysis, and evaluation of catalysis efficiency in living cells and under biological (relevant) conditions. Catalyst poisoning is a ubiquitous problem in this field, and we propose that future research into the development of physical and kinetic protection strategies may provide a route to improve the reactivity of catalysts in cells.</p

Hydrated lime matrix decreases ruminal biohydrogenation of flaxseed fatty acids

Omega-3 fatty acids are essential nutrients for humans, but dietary intake of these nutrients by many Americans is inadequate due to low consumption of omega-3-rich foods such as fish, walnuts, and flaxseed. In contrast, per capita consumption of red meat is relatively high, but these products normally contain only small amounts of omega-3 fatty acids. Feeding cattle diets that contain omega-3 fatty acids has consistently increased the proportion of the desirable fats that accumulate in beef. Unfortunately, the proportion of dietary omega-3 fats that are deposited into beef tissues is relatively low, because microorganisms within the rumen biohydrogenate the unsaturated omega-3 fatty acids extensively to produce the saturated fats that are characteristic of beef fat. Encapsulation of fats has been proposed as a method for improving efficiency of transfer of omega-3 fats into beef. Encapsulation processes apply a protective barrier on the surface of fats or fat-containing feeds, which theoretically decreases fats’ susceptibility to microbial biohydrogenation. Protective coatings must remain intact to retain their functionality, and physical damage to the coatings that occurs with normal handling can result in poor efficacy because the core material is exposed to microorganisms in the rumen. Embedding feed particles within a homogeneous protective matrix constitutes a potentially useful alternative to protective surface barriers. The matrix is created by mixing feed particles that are to be protected with a suitable matrix material that is resistant to microbial digestion and subsequently forming the mixture into pills. In cases where physical damage occurs, exposure of the core material is confined to the broken surface, and the remainder of the matrix retains its ruminal stability. The objective of this study was to determine if embedding flaxseed within a matrix of hydrated dolomitic lime could be used as a method to decrease biohydrogenation of polyunsaturated omega-3 fatty acids, thus improving efficiency of omega-3 fatty acids absorption into the bloodstream

SNA and SNB Angles in a Population of Nubian Schoolchildren

The descriptive statistics for the sella-nasion-A Point (SNA) and sella-nasion-B point (SNB) angles computed from a sample of Nubian schoolchildren are presented, by age and sex, and compared with the analogous statistics for American Caucasian schoolchildren .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67163/2/10.1177_00220345750540041101.pd

Pirate Bri’s Grocery Adventure: Teaching Food Literacy through Shopping

Food Literacy (FL) is associated with the improvement of autonomy and confidence around food, healthier dietary intake, and chronic disease prevention. However, to date, behaviour change research at CHI has focused on motivating healthy eating mainly through weight loss and calorie control, which can lead to poor nutritional choices as consumers optimize caloric intake over a balanced diet. To address this gap, we designed a mobile game called Pirate Bri’s Grocery Adventure, that seeks to improve FL through a situated learning approach to grocery shopping. Our game leverages Self Determination Theory (SDT) to build a player’s competence, autonomy, and relatedness as shoppers are encouraged to develop an understanding of the nutritional benefits of foods and are rewarded for balancing sugar, sodium, fats and fibre in their purchases.Natural Sciences and Engineering Research Counci

No Evidence for a Cumulative Impact Effect on Concussion Injury Threshold

Recent studies using a helmet-based accelerometer system (Head Impact Telemetry System [HITS]) have demonstrated that concussions result from a wide range of head impact magnitudes. Variability in concussion thresholds has been proposed to result from the cumulative effect of non-concussive head impacts prior to injury. We used the HITS to collect biomechanical data representing >100,000 head impacts in 95 high school football players over 4 years. The cumulative impact histories prior to 20 concussive impacts in 19 athletes were compared to the cumulative impact histories prior to the three largest magnitude non-concussive head impacts in the same athletes. No differences were present in any impact history variable between the concussive and non-concussive high magnitude impacts. These analyses included the number of head impacts, cumulative HIT severity profile value, cumulative linear acceleration, and cumulative rotational acceleration during the same practice or game session, as well as over the 30-min and 1 week preceding these impacts. Our data do not support the proposal that impact volume or intensity influence concussion threshold in high school football athletes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90490/1/neu-2E2011-2E1910.pd

On the Perturbative Nature of Color Superconductivity

Color superconductivity is a possible phase of high density QCD. We present a systematic derivation of the transition temperature, T_C, from the QCD Lagrangian through study of the di-quark proper vertex. With this approach, we confirm the dependence of T_C on the coupling g, namely $T_C \sim \mu g^{-5} e^{-\kappa/g}$, previously obtained from the one-gluon exchange approximation in the superconducting phase. The diagrammatic approach we employ allows us to examine the perturbative expansion of the vertex and the propagators. We find an additional O(1) contribution to the prefactor of the exponential from the one-loop quark self energy and that the other one-loop radiative contributions and the two gluon exchange vertex contribution are subleading.Comment: 13 pages, 3 figures, revtex, details and discussion expande

National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010

Background National estimates for the numbers of babies born small for gestational age and the comorbidity with preterm birth are unavailable. We aimed to estimate the prevalence of term and preterm babies born small for gestational age (term-SGA and preterm-SGA), and the relation to low birthweight (\u3c2500 \u3eg), in 138 countries of low and middle income in 2010. Methods Small for gestational age was defined as lower than the 10th centile for fetal growth from the 1991 US national reference population. Data from 22 birth cohort studies (14 low-income and middle-income countries) and from the WHO Global Survey on Maternal and Perinatal Health (23 countries) were used to model the prevalence of term-SGA births. Prevalence of preterm-SGA infants was calculated from meta-analyses. Findings In 2010, an estimated 32·4 million infants were born small for gestational age in low-income and middle-income countries (27% of livebirths), of whom 10·6 million infants were born at term and low birthweight. The prevalence of term-SGA babies ranged from 5·3% of livebirths in east Asia to 41·5% in south Asia, and the prevalence of preterm-SGA infants ranged from 1·2% in north Africa to 3·0% in southeast Asia. Of 18 million low-birthweight babies, 59% were term-SGA and 41% were preterm-SGA. Two-thirds of small-for-gestational-age infants were born in Asia (17·4 million in south Asia). Preterm-SGA babies totalled 2·8 million births in low-income and middle-income countries. Most small-for-gestational-age infants were born in India, Pakistan, Nigeria, and Bangladesh. Interpretation The burden of small-for-gestational-age births is very high in countries of low and middle income and is concentrated in south Asia. Implementation of effective interventions for babies born too small or too soon is an urgent priority to increase survival and reduce disability, stunting, and non-communicable diseases

An assessment of the strength of knots and splices used as eye terminations in a sailing environment

Research into knots, splices and other methods of forming an eye termination has been limited, despite the fact that they are essential and strongly affect the performance of a rope. The aim of this study was to carry out a comprehensive initial assessment of the breaking strength of eye terminations commonly used in a sailing environment, thereby providing direction for further work in the field. Supports for use in a regular tensile testing machine were specially developed to allow individual testing of each sample and a realistic spread of statistical data to be obtained. Over 180 break tests were carried out on four knots (the bowline, double bowline, figure-of-eight loop and perfection loop) and two splices (three-strand eye splice and braid-on-braid splice). The factors affecting their strength were investigated. A statistical approach to the analysis of the results was adopted. The type of knot was found to have a significant effect on the strength. This same effect was seen in both types of rope construction (three-strand and braid-on-braid). Conclusions were also drawn as to the effect of splice length, eye size, manufacturer and rope diameter on the breaking strength of splices. Areas of development and further investigation were identified