10,218 research outputs found
Long-term benzodiazepine and Z-drugs use in England:a survey of general practice
BackgroundCurrent British National Formulary (BNF) guidelines state that benzodiazepines and zolpidem, zopiclone, and zaleplon, commonly known as Z-drugs (BZD), be prescribed for no more than 4 weeks, although anecdotal data suggest that many patients are prescribed BZDs for much longer. As there are no recent, evidence-based estimates of long-term (>12 months) BZD use in England, the scale of this potential problem is unknown.AimTo produce the first reliable, evidence-based estimate of long-term BZD use in England.Design and settingEstimates of long-term BZD use in England were projected from data obtained from a survey conducted in 2014â2015 by the Bridge Project, a prescribed-drug withdrawal support charity in the North of England (Bradford).MethodPercentages of long-term users of BZD were derived from the survey, by sampling primary care GP surgeries with around 100 000 registered patients, and these were applied to English NHS patient numbers. The data were filtered to exclude the very young and old, and those with other health issues.ResultsThe mean percentage of registered patients prescribed BZDs for more than a year in the survey sample is 0.69% (95% confidence interval [CI] = 0.54 to 0.84). Applying this value to national patient numbers yields a mean projection of 296 929 (95% CI = 232 553 to 361 305) long-term users of BZD in England. The data also suggest that as many as 119 165 of these patients may be willing to accept prescribed drug dependency withdrawal services.ConclusionMore than a quarter of a million people in England are likely to be taking highly dependency-forming hypnotic medication far beyond the recommended time scales. As there is evidence that long-term use of BZDs causes adverse physiological and neurological effects, and protracted withdrawal (with associated complications), this represents a serious public health problem.</jats:sec
Effects of Measurement back-action in the stabilization of a Bose-Einstein condensate through feedback
We apply quantum filtering and control to a particle in a harmonic trap under
continuous position measurement, and show that a simple static feedback law can
be used to cool the system. The final steady state is Gaussian and dependent on
the feedback strength and coupling between the system and probe. In the limit
of weak coupling this final state becomes the ground state. An earlier model by
Haine et. al. (PRA 69, 2004) without measurement back-action showed dark
states: states that did not display error signals, thus remaining unaffected by
the control. This paper shows that for a realistic measurement process this is
not true, which indicates that a Bose-Einstein condensate may be driven towards
the ground state from any arbitrary initial state.Comment: 1 Tex, 4 PS pictures, 1 bbl fil
USDA News Release Usage Survey; The Al Newsletter as Marketing Communications Tool ; Missouri Farm News Service Usage Survey
Three Research Briefs: USDA News Release Usage Survey; The Al Newsletter as Marketing Communications Tool ; Missouri Farm News Service Usage Surve
Stellar Collisions and the Interior Structure of Blue Stragglers
Collisions of main sequence stars occur frequently in dense star clusters. In
open and globular clusters, these collisions produce merger remnants that may
be observed as blue stragglers. Detailed theoretical models of this process
require lengthy hydrodynamic computations in three dimensions. However, a less
computationally expensive approach, which we present here, is to approximate
the merger process (including shock heating, hydrodynamic mixing, mass
ejection, and angular momentum transfer) with simple algorithms based on
conservation laws and a basic qualitative understanding of the hydrodynamics.
These algorithms have been fine tuned through comparisons with the results of
our previous hydrodynamic simulations. We find that the thermodynamic and
chemical composition profiles of our simple models agree very well with those
from recent SPH (smoothed particle hydrodynamics) calculations of stellar
collisions, and the subsequent stellar evolution of our simple models also
matches closely that of the more accurate hydrodynamic models. Our algorithms
have been implemented in an easy to use software package, which we are making
publicly available (see http://vassun.vassar.edu/~lombardi/mmas/). This
software could be used in combination with realistic dynamical simulations of
star clusters that must take into account stellar collisions.Comment: This revised version has 37 pages, 13 figures, 4 tables; submitted to
ApJ; for associated software package, see
http://vassun.vassar.edu/~lombardi/mmas/ This revised version presents
additional comparisons with SPH results and slightly improved merger recipe
Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus
Background: The Prolactin (PRL) hormone gene family shows considerable variation among placental mammals. Whereas there is a single PRL gene in humans that is expressed by the pituitary, there are an additional 22 genes in mice including the placental lactogens (PL) and Prolactin-related proteins (PLPs) whose expression is limited to the placenta. To understand the regulation and potential functions of these genes, we conducted a detailed temporal and spatial expression study in the placenta between embryonic days 7.5 and E18.5 in three genetic strains
The outsourcing of social care in Britain : what does it mean for voluntary sector workers?
While recent decades have witnessed a growth in the outsourcing of public services in Britain, the post-1997 UK Labour governments have sought to put in place mechanisms aimed at encouraging long-term collaborative contracting relationships marked by less reliance on cost-based competition. This article explores empirically how far these mechanisms have achieved their aims and thereby acted to protect the employment conditions of staff, and links this exploration to debates concerning the employment implications of organizational reforms within public sectors internationally. It concludes that in terms of bringing income security to the voluntary sector and stability to employment terms and conditions these efforts have been unsuccessful, and consequently casts doubts on more optimistic interpretations of the employment effects of organizational restructuring in the British public sector
Interactions of asbestos-activated macrophages with an experimental fibrosarcoma
Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro
- âŠ