5,913 research outputs found
A community approach to road safety education using practical training methods : the Drumchapel project
Research shows that practical training methods, in which children receive guided experience of solving traffic problems in realistic traffic situations, are amongst the most effective in improving children's pedestrian competence. However, practical training is both time consuming and labour intensive, making it difficult to capitalise on the strengths of the method. The report describes a solution to this problem by adopting a community participation approach in which local volunteers carried out all roadside training, working in co-operation with schools and project staff. The project took place in an area of Glasgow known for its exceptionally high child pedestrian accident rate
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Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.
Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an understanding of the pathogenesis of the disease has been hampered by a lack of accurate animal models. Here, we explore the dynamics of retinal cellular changes in the Nile rat (Arvicanthis niloticus), a carbohydrate-sensitive model for type 2 diabetes. The early retinal changes in diabetic Nile rats included increased acellular capillaries and loss of pericytes that correlated linearly with the duration of diabetes. These vascular changes occurred in the presence of microglial infiltration but in the absence of retinal ganglion cell loss. After a prolonged duration of diabetes, the Nile rat also exhibits a spectrum of retinal lesions commonly seen in the human condition including vascular leakage, capillary non-perfusion, and neovascularization. Our longitudinal study documents a range and progression of retinal lesions in the diabetic Nile rat remarkably similar to those observed in human diabetic retinopathy, and suggests that this model will be valuable in identifying new therapeutic strategies
Scaling in Plasticity-Induced Cell-Boundary Microstructure: Fragmentation and Rotational Diffusion
We develop a simple computational model for cell boundary evolution in
plastic deformation. We study the cell boundary size distribution and cell
boundary misorientation distribution that experimentally have been found to
have scaling forms that are largely material independent. The cell division
acts as a source term in the misorientation distribution which significantly
alters the scaling form, giving it a linear slope at small misorientation
angles as observed in the experiments. We compare the results of our simulation
to two closely related exactly solvable models which exhibit scaling behavior
at late times: (i) fragmentation theory and (ii) a random walk in rotation
space with a source term. We find that the scaling exponents in our simulation
agree with those of the theories, and that the scaling collapses obey the same
equations, but that the shape of the scaling functions depend upon the methods
used to measure sizes and to weight averages and histograms
Dynamics and Topological Aspects of a Reconstructed Two-Dimensional Foam Time Series Using Potts Model on a Pinned Lattice
We discuss a method to reconstruct an approximate two-dimensional foam
structure from an incomplete image using the extended Potts mode with a pinned
lattice we introduced in a previous paper. The initial information consists of
the positions of the vertices only. We locate the centers of the bubbles using
the Euclidean distance-map construction and assign at each vertex position a
continuous pinning field with a potential falling off as . We nucleate a
bubble at each center using the extended Potts model and let the structure
evolve under the constraint of scaled target areas until the bubbles contact
each other. The target area constraint and pinning centers prevent further
coarsening. We then turn the area constraint off and let the edges relax to a
minimum energy configuration. The result is a reconstructed structure very
close to the simulation. We repeated this procedure for various stages of the
coarsening of the same simulated foam and investigated the simulation and
reconstruction dynamics, topology and area distribution, finding that they
agree to good accuracy.Comment: 31 pages, 20 Postscript figures Accepted in the Journal of
Computational Physic
Impurity effects on the melting of Ni clusters
We demonstrate that the addition of a single carbon impurity leads to
significant changes in the thermodynamic properties of Ni clusters consisting
of more than a hundred atoms. The magnitude of the change induced is dependent
upon the parameters of the Ni-C interaction. Hence, thermodynamic properties of
Ni clusters can be effectively tuned by the addition of an impurity of a
particular type. We also show that the presence of a carbon impurity
considerably changes the mobility and diffusion of atoms in the Ni cluster at
temperatures close to its melting point. The calculated diffusion coefficients
of the carbon impurity in the Ni cluster can be used for a reliable estimate of
the growth rate of carbon nanotubes.Comment: 27 pages, 13 figure
Prologue to Power: Selecting Supreme Court Justices
Review of God Save This Honorable Court: How the Choice of Supreme Court Justices Shapes Our History, by Laurence A. Tribe (Random House, 1985)
Getting to Know Harlan: A New Approach to Judicial Biography? Book Review: The Republic According to John Marshall Harlan. by Linda Przybyszewski
Book review: The Republic According to John Marshall Harlan. By Linda Przybyszewski. University of North Carolina Press. 1999. Pp. xii, 286. Reviewed by: James A. Thomso
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Evaluating the structure and magnitude of the ash plume during the initial phase of the 2010 Eyjafjallajökull eruption using lidar observations and NAME simulations
The Eyjafjallajökull volcano in Iceland erupted explosively on 14 April 2010, emitting a plume of ash into the atmosphere. The ash was transported from Iceland toward Europe where mostly cloud-free skies allowed ground-based lidars at Chilbolton in England and Leipzig in Germany to estimate the mass concentration in the ash cloud as it passed overhead. The UK Met Office's Numerical Atmospheric-dispersion Modeling Environment (NAME) has been used to simulate the evolution of the ash cloud from the Eyjafjallajökull volcano during the initial phase of the ash emissions, 14–16 April 2010. NAME captures the timing and sloped structure of the ash layer observed over Leipzig, close to the central axis of the ash cloud. Relatively small errors in the ash cloud position, probably caused by the cumulative effect of errors in the driving meteorology en route, result in a timing error at distances far from the central axis of the ash cloud. Taking the timing error into account, NAME is able to capture the sloped ash layer over the UK. Comparison of the lidar observations and NAME simulations has allowed an estimation of the plume height time series to be made. It is necessary to include in the model input the large variations in plume height in order to accurately predict the ash cloud structure at long range. Quantitative comparison with the mass concentrations at Leipzig and Chilbolton suggest that around 3% of the total emitted mass is transported as far as these sites by small (<100 μm diameter) ash particles
Evaluating the potential for the environmentally sustainable control of foot and mouth disease in Sub-Saharan Africa
Strategies to control transboundary diseases have in the past generated unintended negative consequences for both the environment and local human populations. Integrating perspectives from across disciplines, including livestock, veterinary and conservation sectors, is necessary for identifying disease control strategies that optimise environmental goods and services at the wildlife-livestock interface. Prompted by the recent development of a global strategy for the control and elimination of foot-and-mouth disease (FMD), this paper seeks insight into the consequences of, and rational options for potential FMD control measures in relation to environmental, conservation and human poverty considerations in Africa. We suggest a more environmentally nuanced process of FMD control that safe-guards the integrity of wild populations and the ecosystem dynamics on which human livelihoods depend while simultaneously improving socio-economic conditions of rural people. In particular, we outline five major issues that need to be considered: 1) improved understanding of the different FMD viral strains and how they circulate between domestic and wildlife populations; 2) an appreciation for the economic value of wildlife for many African countries whose presence might preclude the country from ever achieving an FMD-free status; 3) exploring ways in which livestock production can be improved without compromising wildlife such as implementing commodity-based trading schemes; 4) introducing a participatory approach involving local farmers and the national veterinary services in the control of FMD; and 5) finally the possibility that transfrontier conservation might offer new hope of integrating decision-making at the wildlife-livestock interface
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