Migraines During Pregnancy Linked to Stroke and Vascular Diseases: US Population-Based Case-Control Study

Objective To examine the association between migraine and cardiovascular diseases during pregnancy. Design US population based case-control study. Setting Nationwide inpatient sample, from the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality. Population 18 345 538 pregnancy related discharges from 2000 to 2003. Main outcome measures Diagnosis of migraine, as identified by ICD-9 codes 346.0 and 346.1. Stroke and other vascular diseases were identified by using standard ICD-9 codes. Results From the hospital discharges with a pregnancy discharge code, 33 956 migraine codes were identified: 185 per 100 000 deliveries. Diagnoses that were jointly associated with migraine codes during pregnancy (excluding pre-eclampsia) were stroke (odds ratio 15.05, 95% confidence interval 8.26 to 27.4), myocardial infarction/heart disease (2.11, 1.76 to 2.54), pulmonary embolus/venous thromboembolism (3.23, 2.06 to 7.07), and hypertension (8.61, 6.43 to 11.54), as well as preeclampsia/gestational hypertension (2.29, 2.13 to 2.46), smoking (2.85, 2.53 to 3.21), and diabetes (1.96, 1.64 to 2.35). However, migraine was not associated with several non-vascular diagnoses (pneumonia, transfusions, postpartum infection or haemorrhage). Conclusions In this large, population based sample of pregnant women admitted to hospital, a strong relation existed between active peripartum migraine and vascular diagnoses during pregnancy. Because these data do not allow determination of which came first, migraine or the vascular condition, prospective studies of pregnant women are needed to explore this association further

The Impact of Client Expertise, Client Gender and Auditor Gender on Auditors' Judgments

The purpose of the current study is to assess the extent to which auditors’ judgments are affected by client expertise, client gender and auditor gender. Prior audit research suggests that auditors place more weight on evidence received from clients who possess higher, relative to lower, expertise (Anderson et al. 1994b; Bamber 1983; Hirst 1994; Margheim 1986; Rebele et al. 1988). We extend this line of research by suggesting that client expertise interacts with client gender during the auditor-client inquiry process, and examining the degree to which male and female auditors respond differently to these two source attributes. A total of 158 experienced auditors participated in a between-participants experiment with two manipulated variables (client expertise - low or high; client gender - male or female) and one measured variable (auditor gender - male or female). In a client-inquiry scenario, the auditors exhibited greater belief revision when the client possessed relatively higher expertise and when the client was male. A significant three-way interaction suggests that when client expertise was high, relative to low, the male favorability bias was reduced for male auditors; however, surprisingly, the bias was increased for female auditors. Post-experiment debriefing items indicate that male (female) auditors believe that male managers inherently possess a higher (similar) level of managerial ability. Comparing the managerial ability findings to the behavioral responses suggests a potential disconnect between the female auditors’ beliefs and actions. Since one of the hallmarks of the audit profession lies in the concept of objectivity, the results of this study indicate that audit researchers and practitioners need to better understand the implications of negative gender stereotypes toward women managers

Clinical evaluation of the Shin-Nippon SRW-5000 autorefractor in adults:an update

Purpose: The Shin-Nippon SRW-5000 is an open view autorefractor that superseded the Canon R-1 autorefractor in the mid-1990s and has been used widely in optometry and vision science laboratories. It has been used to measure refractive error, accommodation responses both statically and dynamically, off-axis refractive error, and adapted to measure pupil size. This paper presents an overview of the original 2001 clinical evaluation of the SRW-5000 in adults (Mallen et al., Ophthal Physiol Opt 2001; 21: 101) and provides an update on the use and modification of the instrument since the original publication. Recent findings: The SRW-5000 instrument, and the family of devices which followed, have shown excellent validity, repeatability, and utility in clinical and research settings. The instruments have also shown great potential for increased research functionality following a number of modifications. Summary: The SRW-5000 and its derivatives have been, and continue to be, of significant importance in our drive to understand myopia progression, myopia control techniques, and oculomotor function in human vision

Solution of the gypsum cliff (Permian Middle Marl) by the River Ure at Ripon Parks, North Yorkshire

Gypsum in the cliff on the west bank of the River Ure at Ripon Parks is being dissolved by the river. The solution rate has been determined from the solution of a large fallen block in the river and is close to laboratory experimental values. In the centre of the river and around the gypsum block flow rates of 1 m/s have been measured. Laboratory based experiments suggest that such rates would produce undercutting of massive gypsum at about 1.7 m/year. However, flow rates adjacent to the cliff are substantially reduced and much slower rates of undercutting, around 0.10 to 0.18 m/year, are predicted. Observed minimum rates of undercutting are close to these values. The massive gypsum at the southern end of the cliff appears to have been undercut up to 5 m in 50 to 60 years, i.e. between 0.10 and 0.08 m/year, and the northern part of the cliff has been undercut a similar distance in around 100 years

Covers of acts over monoids II

In 1981 Edgar Enochs conjectured that every module has a flat cover and finally proved this in 2001. Since then a great deal of effort has been spent on studying different types of covers, for example injective and torsion free covers. In 2008, Mahmoudi and Renshaw initiated the study of flat covers of acts over monoids but their definition of cover was slightly different from that of Enochs. Recently, Bailey and Renshaw produced some preliminary results on the `other' type of cover and it is this work that is extended in this paper. We consider free, divisible, torsion free and injective covers and demonstrate that in some cases the results are quite different from the module case

A Novel Approach to the Common Due-Date Problem on Single and Parallel Machines

This paper presents a novel idea for the general case of the Common Due-Date (CDD) scheduling problem. The problem is about scheduling a certain number of jobs on a single or parallel machines where all the jobs possess different processing times but a common due-date. The objective of the problem is to minimize the total penalty incurred due to earliness or tardiness of the job completions. This work presents exact polynomial algorithms for optimizing a given job sequence for single and identical parallel machines with the run-time complexities of $O(n \log n)$ for both cases, where $n$ is the number of jobs. Besides, we show that our approach for the parallel machine case is also suitable for non-identical parallel machines. We prove the optimality for the single machine case and the runtime complexities of both. Henceforth, we extend our approach to one particular dynamic case of the CDD and conclude the chapter with our results for the benchmark instances provided in the OR-library.Comment: Book Chapter 22 page

Abelian D-terms and the superpartner spectrum of anomaly-mediated supersymmetry breaking

We address the tachyonic slepton problem of anomaly mediated supersymmetry breaking using abelian D-terms. We demonstrate that the most general extra U(1) symmetry that does not disrupt gauge coupling unification has a large set of possible charges that solves the problem. It is shown that previous studies in this direction that added both an extra hypercharge D-term and another D-term induced by B-L symmetry (or similar) can be mapped into a single D-term of the general ancillary U(1)_a. The U(1)_a formalism enables identifying the sign of squark mass corrections which leads to an upper bound of the entire superpartner spectrum given knowledge of just one superpartner mass.Comment: 10 pages, 2 figures, [v2] reference added, [v3] Eq. (9) corrected, results unaffected, [v4] version to be published in Phys. Rev. D, expanded parameter space for figures to match tex

Inflation with a constant ratio of scalar and tensor perturbation amplitudes

The single scalar field inflationary models that lead to scalar and tensor perturbation spectra with amplitudes varying in direct proportion to one another are reconstructed by solving the Stewart-Lyth inverse problem to next-to-leading order in the slow-roll approximation. The potentials asymptote at high energies to an exponential form, corresponding to power law inflation, but diverge from this model at low energies, indicating that power law inflation is a repellor in this case. This feature implies that a fine-tuning of initial conditions is required if such models are to reproduce the observations. The required initial conditions might be set through the eternal inflation mechanism. If this is the case, it will imply that the spectral indices must be nearly constant, making the underlying model observationally indistinguishable from power law inflation.Comment: 20 pages, 7 figures. Major changes to the Introduction following referee's comments. One figure added. Some other minor changes. No conclusion was modifie

Real-time PCR assays for detection and quantification of early P. falciparum gametocyte stages

Introduction The use of reverse transcription, quantitative qRT-PCR assays for detection and quantification of late gametocyte stages has revealed the high transmission capacity of the human malaria parasite, Plasmodium falciparum. A full understanding how the parasite adjusts its transmission in response to varying in-host environmental conditions during natural infections requires simultaneous quantification of early and late gametocytes. Here, we describe qRT-PCR assays that are specific for detection and quantification of early-stage gametocytes of P. falciparum. Methods The assays are based on expression of known early gametocyte genes (pfpeg4, pfg27, pfge1, pfge3 and pfgexp5). The specificity of the qRT-PCR assays was tested using purified stage II and stage V gametocytes. These validated assays were used with qRT-PCR assays targeting late stage (pfs25) and all-stage (pfs16) gametocyte-specific transcripts to quantify gametocytes in natural P. falciparum infections and in a controlled human clinical infection study. Results The relative expression of pfpeg4, pfg27 and pfge3, but not of pfge1 and pfgexp5, was significantly higher in purified stage II compared to stage V gametocytes, indicating early gametocyte specificity. In natural infections, 71.2% of individuals had both early and late gametocyte transcripts (pfpeg4/pfg27 plus pfs25), 12.6% harboured only early gametocytes transcripts (pfpeg4/pfg27), and 15.2% had only late gametocytes transcripts (pfs25). In natural infections, the limit of detection was equivalent to 190 and 390 gametocytes/mL blood for pfpeg4 and pfg27, respectively. In infected volunteers, transcripts of pfpeg4 and pfg27 were detected shortly after the onset of blood stage infection, demonstrating the specificity of the assays. Conclusion The pfpeg4 and pfg27 qRT-PCR assays can be used specifically to quantify circulating immature gametocytes. Quantification of early gametocytes will improve understanding of epidemiological processes that modulate P. falciparum transmission and enhance the evaluation of transmission blocking interventions

Flux transitions in a superconducting ring

We perform a numeric study of the flux transitions in a superconducting ring at fixed temperature, while the applied field is swept at an ideally slow rate. The current around the ring and its free energy are evaluated. We partially explain some of the known experimental features, and predict a considerably large new feature: in the vicinity of a critical field, giant jumps are expected