A simple and green synthesis of highly functionalized quinoline derivatives using zinc oxide nanoparticles

1548-1554A simple and one pot method has been designed for the synthesis of highly substituted quinoline derivatives using ZnO nanoparticles in aqueous medium by means of three component condensation reaction of aromatic aldehydes, malononitrile and substituted anilines via Knoevenagel condensation followed by Michael addition in water. This new method has many advantages over reported methods like easy work-up, operational simplicity and excellent yields with short reaction time

Uncatalyzed four-component synthesis of pyrazolopyranopyrimidine derivatives and their antituberculosis activities

<p>Fused pyrazolopyranopyrimidines containing both biologically active pyranopyrazole and pyranopyrimidine compounds were synthesized using a one-pot, four-component reaction of ethyl aceto acetate, hydrazine hydrate, benzaldehydes, and thiobarbituric acid without catalyst in ethanol. All target compounds obtained in very good to excellent yields over short reaction times by adapting a simple workup procedure. All the synthesized compounds exhibited good to excellent antituberculosis activities. The results shown that 4-(1<i>H</i>-imidazol-2-yl)-3-methyl-7-thioxo-4,6,7,8-tetrahydropyrazolo[4’,3′:5,6]pyrano[2,3-<i>d</i>] pyrimidin-5(1<i>H</i>)-one (<b>5a</b>) is a good antitubercular agent, as good as the standard streptomycin drug, based on minimum inhibitory concentration (MIC).</p