1 research outputs found
Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures
Solubilities of carvedilol (CVD)
in binary mixtures of (ethanol
+ propylene glycol (PG)) at 298.2, 303.2, 308.2, and 313.2 K are reported.
The modified versions of the vanât Hoff and Gibbs equations
were used to calculate the thermodynamic properties (enthalpy (Î<i>H</i>°), entropy (Î<i>S</i>°), and
Gibbs energy (Î<i>G</i>°) standard changes of
solutions) for CVD dissolved in (ethanol (1) + PG (2)) mixtures from
the solubility data. The solubility data of CVD in (ethanol (1) +
PG (2)) at different temperatures were correlated using different
mathematical models, i.e., the JouybanâAcree model, a combination
of the JouybanâAcree model with the vanât Hoff model,
and two modified versions of the JouybanâAcree model. Solubility
data of seven drugs in (ethanol (1) + PG (2)) at different temperatures
were used to develop a quantitative structureâproperty relationship
model for predicting solubility in solvent mixtures. In addition,
enthalpyâentropy compensation using Î<i>H</i>° vs Î<i>G</i>° and Î<i>H</i>° vs <i>T</i>ÎS° which explains the mechanism
of cosolvency at different temperatures was discussed