Solubility
of Carvedilol in Ethanol + Propylene Glycol
Mixtures at Various Temperatures
- Publication date
- Publisher
Abstract
Solubilities of carvedilol (CVD)
in binary mixtures of (ethanol
+ propylene glycol (PG)) at 298.2, 303.2, 308.2, and 313.2 K are reported.
The modified versions of the van’t Hoff and Gibbs equations
were used to calculate the thermodynamic properties (enthalpy (Δ<i>H</i>°), entropy (Δ<i>S</i>°), and
Gibbs energy (Δ<i>G</i>°) standard changes of
solutions) for CVD dissolved in (ethanol (1) + PG (2)) mixtures from
the solubility data. The solubility data of CVD in (ethanol (1) +
PG (2)) at different temperatures were correlated using different
mathematical models, i.e., the Jouyban–Acree model, a combination
of the Jouyban–Acree model with the van’t Hoff model,
and two modified versions of the Jouyban–Acree model. Solubility
data of seven drugs in (ethanol (1) + PG (2)) at different temperatures
were used to develop a quantitative structure–property relationship
model for predicting solubility in solvent mixtures. In addition,
enthalpy–entropy compensation using Δ<i>H</i>° vs Δ<i>G</i>° and Δ<i>H</i>° vs <i>T</i>ΔS° which explains the mechanism
of cosolvency at different temperatures was discussed