Short Online Compassionate Intervention Based On Mindful Self-compassion Program

Objectives. The Mindful Self-Compassion (MSC) program is an empirically-developed group intervention aimed to cultivate self-compassion. Sample and setting. A randomized control trial was conducted with pre-, post-measurements, and two-month follow-up. A total of 122 participants were recruited from a general community by convenience sampling. They were randomly allocated to the Compassionate intervention (CI) based on MSC and to a control condition with no treatment. Hypotheses. The authors hypothesised that participation in the CI based on the MSC would decrease self-criticism and increase self-reassurance and self-compassion. Statistical analysis. SPSS Statistics-20, program R, and the package nparLD for the statistical analysis. Non-parametric rank-based test for longitudinal data (pretest-postest design) was employed. Results. This version of the CI based on the MSC significantly increased levels of selfcompassion and self-reassurance as reported immediately post intervention and at two-month follow-up. The CI based on the MSC was also effective at reducing self-uncompassionate responding, which was only present immediately post intervention. Self-compassion is responsive to improvement following a short-term online intervention of CI based on the MSC which suggests that interventions designed to increase self-compassion can be provided online to broader populations without direct involvement of mental health professionals. Study limitation. Participants allocated to the CI were not exposed to the full experience of the MSC but only to a selected number of exercises from the MSC program

Introduction of the European Union case definitions to primary care physicians has improved the quality of communicable diseases notification in Tuzla, Bosnia and Herzegovina

Aim: The Public Health Reform II project was implemented in Bosnia and Herzegovina from December 2011 to December 2013 and was funded by the European Union Aid schema. The principal aim of the project was to strengthen public health services in the country through improved control of public health threats. Workshops for primary care physicians were provided to improve the situation and increase communicable diseases notification rates in eight selected primary care centres. They were followed with visits from the project’s implementing team to verify the effects of trainings. Methods: The quality of notifications from physicians in Tuzla region was compared before and after the workshop. The timeliness was used as an indicator of quality. Medians of timeliness before and after the training were compared by use of Wilcoxon test, whereas the averages of timeliness were compared by use of the t-test. Results: There were 980 reported cases, 80% before the training and 20% after the training. A lower median of timeliness for all the reported cases after the training was statistically significant compared to the median value before the training. A similar picture was revealed for specific diseases i.e. tuberculosis and enteritis, not so for scarlet fever and scabies. Conclusion: The significant reduction in time response between the first symptoms and disease diagnosis indicates the positive impact of the training program in Tuzla. Hence, primary care physicians provided better quality of reported data after the training course

A naturally occurring variant of the human prion protein completely prevents prion disease

Mammalian prions, transmissible agents causing lethal neurodegenerative diseases, are composed of assemblies of misfolded cellular prion protein (PrP)1. A novel PrP variant, G127V, was under positive evolutionary selection during the epidemic of kuru—an acquired prion disease epidemic of the Fore population in Papua New Guinea—and appeared to provide strong protection against disease in the heterozygous state2. Here we have investigated the protective role of this variant and its interaction with the common, worldwide M129V PrP polymorphism. V127 was seen exclusively on a M129 PRNP allele. We demonstrate that transgenic mice expressing both variant and wild-type human PrP are completely resistant to both kuru and classical Creutzfeldt–Jakob disease (CJD) prions (which are closely similar) but can be infected with variant CJD prions, a human prion strain resulting from exposure to bovine spongiform encephalopathy prions to which the Fore were not exposed. Notably, mice expressing only PrP V127 were completely resistant to all prion strains, demonstrating a different molecular mechanism to M129V, which provides its relative protection against classical CJD and kuru in the heterozygous state. Indeed, this single amino acid substitution (G→V) at a residue invariant in vertebrate evolution is as protective as deletion of the protein. Further study in transgenic mice expressing different ratios of variant and wild-type PrP indicates that not only is PrP V127 completely refractory to prion conversion but acts as a potent dose-dependent inhibitor of wild-type prion propagation