37 research outputs found
Lokalitet nr. 219-3 Collstrupgrunden:Udredning vedr. forureningssituationen pĂĽ og omkring grunden 1977 â 2009
Full scale amendment of a contaminated wood impregnation site with iron water treatment residues
OL, politik og sport - En introduktion
Artiklen giver en introduktion til artiklerne i første nummer af Forum for IdrÌt
OL, politik og sport - En introduktion
Artiklen giver en introduktion til artiklerne i første nummer af Forum for IdrÌt
Videnskabelig udredning af international viden om skifergas relateret til en dansk kontekst:DTU, GEUS, DCE
Mental Health Among Patients with non-Hodgkin Lymphoma:a Danish Nationwide Study of Psychotropic Drug Use in 8,750Patients and 43,750 Matched Comparators
Psychological distress following cancer diagnosis may lead to mental health complications including depression and anxiety. NonâHodgkin lymphomas (NHLs) include indolent and aggressive subtypes for which treatment and prognosis differ widely. Incident use of psychotropic drugs (PDsâantidepressants, antipsychotics, and anxiolytics) and its correlation to lymphoma types can give insights into the psychological distress these patients endure. In this prospective matched cohort study, we used nationwide populationâbased registries to investigate the cumulative risk of PD use in NHL patients compared to a sexâ and ageâmatched cohort from the Danish background population. In addition, contact patterns to psychiatric departments and incident intentional selfâharm or completed suicide were explored. In total, 8750 NHL patients and 43â750 matched comparators were included (median age 68; male:female ratio 1.6). Median followâup was 7.1âyears. Twoâyear cumulative risk of PD use was higher in NHL patients (16.4%) as compared to the matched comparators (5.1%, p <â.01); patients with aggressive NHL subtypes had the highest incidence. Prescription rates were higher in the first years after diagnosis but approached the rate of the matched population 5âyears into survivorship in aggressive NHLs, whereas patients with indolent subtypes continued to be at higher risk. NHL patients had a slightly higher twoâyear risk of suicide/intentional selfâharm (0.3%) as compared to the matched comparators (0.2%, p =â.01). These results demonstrate that mental health complications among NHL patients are frequent. Routine assessment for symptoms of depression and anxiety should be consider as part of standard followâup of NHL patients
ZAK beta is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle
Mechanical inputs give rise to p38 and JNK activation, which mediate adaptive physiological responses in various tissues. In skeletal muscle, contraction-induced p38 and JNK signaling ensure adaptation to exercise, muscle repair, and hypertrophy. However, the mechanisms by which muscle fibers sense mechanical load to activate this signaling have remained elusive. Here, we show that the upstream MAP3K ZAK beta is activated by cellular compression induced by osmotic shock and cyclic compression in vitro, and muscle contraction in vivo. This function relies on ZAKO's ability to recognize stress fibers in cells and Z-discs in muscle fibers when mechanically perturbed. Consequently, ZAK-deficient mice present with skeletal muscle defects characterized by fibers with centralized nuclei and progressive adaptation towards a slower myosin profile. Our results highlight how cells in general respond to mechanical compressive load and how mechanical forces generated during muscle contraction are translated into MAP kinase signaling.Peer reviewe