Economic performance amongst English seaside towns

Within urban and tourism studies, although much research has focused on uneven city prosperity and competitiveness, little is known about factors influencing seaside town economic performance. We adopt a place-based approach to understand its determinants amongst 58 of England’s largest seaside towns drawing on a bespoke database. Through Partial Least Square analysis, Spearman’s Rank Correlation and general linear regression modelling for panel data with random effects, we identify the ‘leaders’ and ‘laggers’ along with a set of associated socio-economic characteristics. These insights enhance understanding of how and why economic performance differs amongst these towns. We highlight implications for addressing such socio-economic disparities across seaside towns, which has wider destination relevance, and use these findings to inform policy which seeks to raise the productivity potential of ‘lagging’ towns

Novel Colicin F-Y of Yersinia frederiksenii Inhibits Pathogenic Yersinia Strains via YiuR-Mediated Reception, TonB Import, and Cell Membrane Pore Formation

A novel colicin type, designated colicin F-Y, was found to be encoded and produced by the strain Yersinia frederiksenii Y27601. Colicin F-Y was active against both pathogenic and nonpathogenic strains of the genus Yersinia. Plasmid YF27601 (5,574 bp) of Y. frederiksenii Y27601 was completely sequenced. The colicin F-Y activity gene (cfyA) and the colicin F-Y immunity gene (cfyI) were identified. The deduced amino acid sequence of colicin F-Y was very similar in its C-terminal pore-forming domain to colicin Ib (69% identity in the last 178 amino acid residues), indicating pore forming as its lethal mode of action. Transposon mutagenesis of the colicin F-Y-susceptible strain Yersinia kristensenii Y276 revealed the yiuR gene (ykris001_4440), which encodes the YiuR outer membrane protein with unknown function, as the colicin F-Y receptor molecule. Introduction of the yiuR gene into the colicin F-Y-resistant strain Y. kristensenii Y104 restored its susceptibility to colicin F-Y. In contrast, the colicin F-Y-resistant strain Escherichia coli TOP10F' acquired susceptibility to colicin F-Y only when both the yiuR and tonB genes from Y. kristensenii Y276 were introduced. Similarities between colicins F-Y and Ib, similarities between the Cir and YiuR receptors, and the detected partial cross-immunity of colicin F-Y and colicin Ib producers suggest a common evolutionary origin of the colicin F-Y-YiuR and colicin Ib-Cir systems

Disadvantage in English seaside resorts : A typology of deprived neighbourhoods

Socio-economic disadvantage experienced by residents of English seaside resorts has been growing over the last decade, and academic and practice-based research is providing better insights into the causes, internal dynamics and appropriate policy responses to these issues in coastal communities. This paper examines the nature and extent of disadvantage in English seaside resorts through analysis of a specially devised spatial and temporal database, which draws together various publicly available sources beyond the population census and Index of Multiple Deprivation. Using univariate, bivariate and multivariate analyses of this database, a new typology of highly deprived resort neighbourhoods has been devised, with clear implications for the formulation of more targeted policy responses. The results also indicate the persistence, complexity and distinct spatial clustering of deprivation, which establishes a case for a much stronger geographical emphasis in future research and policy agendas, including third sector partnerships.Peer reviewe