21 research outputs found
Primary intracranial myxoma - Report of a rare case and review of literature
Myxomas are benign primary tumors of the heart of mesenchymal origin. Neurological complications attributed to atrial myxoma occurs in 10% to 12% of patients, with ischemic presentation due to cerebral infarct in 83%-89% of cases. Few case reports are available of multiple metastatic myxomas from primary inthe heart, despite its slow growing and innocuous histological appearance. Primary intracranial myxomas are extremely rare and only six cases have been reported in literature till date, out of which four were supratentorial in location. As on account of its benign nature, complete surgical resection of the tumor is the recommended treatment
Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance
<p>Abstract</p> <p>Objective</p> <p>The objective was to determine the expression of estrogen and progesterone receptors in vestibular schwannomas as well as to determine predictive factors for estrogen and progesterone receptor positivity.</p> <p>Materials and methods</p> <p>The study included 100 cases of vestibular schwannomas operated from January 2006 to June 2009. The clinical details were noted from the medical case files. Formaldehyde-fixed parafiin-embedded archival vestibular schwannomas specimens were used for the immunohistochemical assessment of estrogen and progesterone receptors.</p> <p>Results</p> <p>Neither estrogen nor progesterone receptors could be detected in any of our cases by means of well known immunohistochemical method using well documented monoclonal antibodies. In the control specimens, a strongly positive reaction could be seen.</p> <p>Conclusion</p> <p>No estrogen and progesterone receptor could be found in any of our 100 cases of vestibular schwannomas. Hence our study does not support a causative role of estrogen and progesterone in the growth of vestibular schwannoma as well as hormonal manipulation in the treatment of this tumor.</p
Coexisting intramedullary schwannoma with intramedullary cysticercus: Report of an unusual collision
Primary spinal melanoma of the cervical leptomeninges: Report of a case with brief review of literature
Central nervous system primary malignant melanoma accounts for
approximately 1% of all melanomas. Primary spinal melanomas are even
more unusual. We report a patient with primary spinal melanoma of the
cervical leptomeninges. The histology of the tumor showed tumor cells
arranged in sheets, ill-defined fascicles and nests and displayed a
moderate grade of cellular and nuclear pleomorphism and mitoses with
abundant pigment in the cytoplasm. The tumor cells were immunoreactive
for HMB-45, and for S-100
Primary melanocytic tumors of the central nervous system: A neuroradiological and clinicopathological study of five cases and brief review of literature
Primary melanocytic tumors of the central nervous system (CNS) are
uncommon lesions. These lesions arise from the melanocytes located
within leptomeninges and include diffuse melanocytosis and meningeal
melanomatosis (seen in neurocutaneous melanosis), melanocytoma, and
malignant melanoma. To study, the clinical course, neuroradiological
features, morphology and immunohistochemistry of primary melanocytic
tumor of CNS. Demographic, clinical and surgico-pathologic findings of
five patients with melanocytic tumors seen between 1996 and 2003 were
studied. In this study, five cases of primary melanocytic tumors have
been reported: four cases of malignant melanoma and one case of
melanocytoma. Three of the 5 cases were intracranial and 2 were spinal.
The mean age in the present study was 26 years. Presenting features
varied according to the location. Primary melanocytic tumor of CNS are
rare. Whenever possible, complete surgical excision is the best
treatment
Lipomatous meningioma: A study of five cases with brief review of literature
Lipomatous meningiomas are an uncommon subtype of meningiomas. In the
present report, the clinical characteristics, neuroimaing and
pathological features of 5 patients (4 males, 1 female; age range,
17-45 years; mean age, 35.2 years) with lipomatous meningioma were
analyzed. The neuro-pathological reevaluation of lipomatous meningioma
involved assessment of histological features proposed by the current
WHO classification. The presence or absence of high whorls, fascicles,
solid growth, glial invasion, necrosis and nuclear pleomorphism was
assessed. The most common presenting symptom was seizures. Location of
tumor was frontal (3 cases), parietal (1 case) and fronto-temporal (1
case). All cases showed radiological features of conventional
meningioma. Complete excision of tumor along with involved dura was
performed in all the patients. Three tumors were meningothelial and 2
were transitional. Tumoral lipid content was variable from 10% to 30%.
In addition, there were microcystic features (2 cases) and psammoma
bodies (1 case). No recurrence was noted in any of our cases till the
last follow-up. Lipomatous meningioma represents a rare distinctive
type of meningioma, with a good prognosis with complete removal