A rare case of cervical fibroid presenting as retained placenta with postpartum hemorrhage

Fibroids during pregnancy are often asymptomatic but sometimes may lead to various complications and unusual presentations. We are reporting an unusual case of cervical fibroid during pregnancy that presented as retained placenta with postpartum hemorrhage following a full term normal vaginal delivery

Overview of liver disorders during pregnancy at a tertiary care centre: Uttarakhand scenario

Background: Liver disorders in pregnancy encompass a spectrum of diseases encountered during antenatal and postnatal period resulting in abnormal liver function tests and hepatobiliary dysfunction or both. This study is aimed at determining the causes of liver disorders during pregnancy and associated maternal and fetal outcomes over a period of 3 years at a tertiary care centre of Dehradun.Methods: All case records of patients with liver disorders during pregnancy from May 2013 to May 2016 were retrieved from medical record department of SGRRIMHS, Dehradun and analyzed for various causes of liver disorders and associated maternal and fetal outcomes.Results: During the three-year study period, 146 pregnant patients were found to have liver disorders. The study found that viral hepatitis was the most common cause of liver disorders followed by Intrahepatic cholestasis of pregnancy IHCP. There were 6 mortalities among the study group out of which hepatitis E was the culprit for maternal mortality in two patients. The serum bilirubin levels were directly proportional to the maternal deaths.Conclusions: Liver disorders during pregnancy are rare but an important cause of maternal and fetal morbidity and mortality. Early recognition, timely referral and aggressive management may lead to better maternal and fetal outcome

Analysis of maternal deaths over a period of three years at a tertiary care centre of Uttarakhand, India

Background: Globally, about 800 women die every day of preventable causes related to pregnancy and childbirth; 20 per cent of these women are from India. The study is aimed at evaluating maternal deaths over a period of three years at a tertiary care centre of Dehradun, India.Methods: This was a retrospective study conducted in the Department of Obstetrics and Gynecology at SGRRIMHS, Dehradun. The case record files of all maternal deaths from January 2015 to December 2017 was obtained from medical record section of the hospital. Maternal age, parity, educational status, antenatal registration, mode of delivery, admission death interval and causes of each maternal death was noted and analysed statistically.Results: There were 48 maternal deaths from January 2015 to December 2017.Maximum deaths were in the age group of 21-25 years. The maternal mortality ratio over a period of three years was 671 per one lac live births. Most of the maternal deaths were due to direct causes like hemorrhage , eclampsia followed by sepsis.Conclusions: Most of the maternal deaths are preventable. High risk cases should be identified at root level and early referral should be the moto. All women need access to antenatal care in pregnancy, skilled care during childbirth, and care and support in the weeks after childbirth. To avoid maternal deaths, unwanted and too-early pregnancies should be avoided. All women, including adolescents, should have access to contraception, safe abortion services to the full extent of the law, and quality post-abortion care. It is particularly important that all births are attended by skilled health professionals, as timely management and treatment can make the difference between life and death for both the mother and the baby

Plant-Derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) Exhibits Growth Inhibitory Effects in Prostate Cancer Cells

The gene Par-4 (Prostate Apoptosis Response 4) was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4) selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV) and apoplast signal peptide (aTP) in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR, and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER) was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT), apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era

"Mother-weights" and lost fathers: parents in South Asian American literature

That parent-child relationships should play a significant role within South Asian American literature is perhaps no surprise, since this is crucial material for any writer. But the particular forms they so often take – a dysfunctional mother-daughter dynamic, leading to the search for maternal surrogates; and the figure of the prematurely deceased father – are more perplexing. Why do families adhere to these patterns in so many South Asian American texts and what does that tell us about this œuvre? More precisely, why are mothers subjected to a harsher critique than fathers and what purpose does this critique serve? How might we interpret the trope of the untimely paternal death? In this article I will seek to answer these questions – arguably key to an understanding of this growing body of writing – by considering works produced between the 1990s and the early twenty-first century by a range of South Asian American writers

Effect of temporal profile of the laser pulse interacting with solid surface on the generation of high harmonics and attosecond pulse trains

The effect of temporal profile of an ultra-intense, ultrashort few-cycle laser pulse incident normally on a solid surface on harmonics generation (HHG) and attosecond pulse trains has numerically been studied. The results of transformation of initially narrow spectrum of the laser pulse into a broad harmonic spectrum are obtained. The reflected signal has the form of a train of ultrashort pulses of duration ~100 attoseconds for the case of a Ti:sapphire laser. The effect of collisions on electron dynamics has been taken into account

Synthesis of 2-(6-fluorobenzothiazole-2'-ylamino)-4-(phenylthioureido)-6-(substituted thioureido)-1,3,5-triazine as antimicrobial agent

1288-12902,4,6-Trichloro-1,3,5-triazine has been reacted selectively with nucleophilic reagents, 6-Fluoro-2-aminobenzothiazole 1, phenyl thioureas 2 and different substituted thioureas 3 to give 2-(6-fluorobenzothiazole-2'-ylamino)-4-(phenylthioureido)-6-(substi­tuted thioureido)-1,3,5-triazine 4. These compounds are evaluated for their antimicrobial activity. The structure of all these compounds have been confirmed by IR, 1H NMR, mass spectral data and elemental analysis. Benzothiazoles, s-triazenes and thioureas exhibit various biological activities

Spectrogram Data Set for Deep-Learning-Based RF Frame Detection

Automated spectrum analysis serves as a troubleshooting tool that helps to diagnose faults in wireless networks such as difficult signal propagation conditions and coexisting wireless networks. It provides a higher monitoring coverage while requiring less expertise compared with manual spectrum analysis. In this paper, we introduce a data set that can be used to train and evaluate deep learning models, capable of detecting frames from different wireless standards as well as interference between single frames. Since manually labeling a high variety of frames in different environments is too challenging, an artificial data generation pipeline was developed. The data set consists of 20,000 augmented signal segments, each containing a random number of different Wi-Fi and Bluetooth frames, their spectral image representations and labels that describe the position and type of frame within the spectrogram. The data set contains results of intermediate processing steps that enable the research or teaching community to create new data sets for specific requirements or to provide new interesting examination examples