36,523 research outputs found
Neural Networks: Implementations and Applications
Artificial neural networks, also called neural networks, have been used successfully in many fields including engineering, science and business. This paper presents the implementation of several neural network simulators and their applications in character recognition and other engineering area
Neural Network Applications
Artificial neural networks, also called neural networks, have been used successfully in many fields including engineering, science and business. This paper presents the implementation of several neural network simulators and their applications in character recognition and other engineering area
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Quantitative surface field analysis: learning causal models to predict ligand binding affinity and pose.
We introduce the QuanSA method for inducing physically meaningful field-based models of ligand binding pockets based on structure-activity data alone. The method is closely related to the QMOD approach, substituting a learned scoring field for a pocket constructed of molecular fragments. The problem of mutual ligand alignment is addressed in a general way, and optimal model parameters and ligand poses are identified through multiple-instance machine learning. We provide algorithmic details along with performance results on sixteen structure-activity data sets covering many pharmaceutically relevant targets. In particular, we show how models initially induced from small data sets can extrapolatively identify potent new ligands with novel underlying scaffolds with very high specificity. Further, we show that combining predictions from QuanSA models with those from physics-based simulation approaches is synergistic. QuanSA predictions yield binding affinities, explicit estimates of ligand strain, associated ligand pose families, and estimates of structural novelty and confidence. The method is applicable for fine-grained lead optimization as well as potent new lead identification
Using genetic algorithms with grammar encoding to generate neural networks
Kitano's approach to neural network design is extended in the sense that not just the neural network structure, but also the values of the weights are coded in the chromosome. Experimental results are presented demonstrating the capability of the technique in the solution of a standard test problem
Composite Fermions and Landau Level Mixing in the Fractional Quantum Hall Effect
The reduction of the energy gap due to Landau level mixing, characterized by
the dimensionless parameter , has
been calculated by variational Monte Carlo for the fractional quantum Hall
effect at filling fractions and 1/5 using a modified version of
Jain's composite fermion wave functions. These wave functions exploit the
Landau level mixing already present in composite fermion wave functions by
introducing a partial Landau level projection operator. Results for the energy
gaps are consistent with experimental observations in -type GaAs, but we
conclude that Landau level mixing alone cannot account for the significantly
smaller energy gaps observed in -type systems.Comment: 11 pages, RevTex, 2 figures in compressed tar .ps forma
Within-Subject Joint Independent Component Analysis of Simultaneous fMRI/ERP in an Auditory Oddball Paradigm
The integration of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) can contribute to characterizing neural networks with high temporal and spatial resolution. This research aimed to determine the sensitivity and limitations of applying joint independent component analysis (jICA) within-subjects, for ERP and fMRI data collected simultaneously in a parametric auditory frequency oddball paradigm. In a group of 20 subjects, an increase in ERP peak amplitude ranging 1â8 ÎŒV in the time window of the P300 (350â700 ms), and a correlated increase in fMRI signal in a network of regions including the right superior temporal and supramarginal gyri, was observed with the increase in deviant frequency difference. JICA of the same ERP and fMRI group data revealed activity in a similar network, albeit with stronger amplitude and larger extent. In addition, activity in the left pre- and post-central gyri, likely associated with right hand somato-motor response, was observed only with the jICA approach. Within-subject, the jICA approach revealed significantly stronger and more extensive activity in the brain regions associated with the auditory P300 than the P300 linear regression analysis. The results suggest that with the incorporation of spatial and temporal information from both imaging modalities, jICA may be a more sensitive method for extracting common sources of activity between ERP and fMRI
Integrating Evolutionary Computation with Neural Networks
There is a tremendous interest in the development of the evolutionary computation techniques as they are well suited to deal with optimization of functions containing a large number of variables. This paper presents a brief review of evolutionary computing techniques. It also discusses briefly the hybridization of evolutionary computation and neural networks and presents a solution of a classical problem using neural computing and evolutionary computing technique
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