食品に含まれるインドール化合物による生活習慣病予防に関する研究

Tohoku University白川仁課

Use Of Nano-Silica To Increase Early Strength And Reduce Setting Time Of Concretes With High Volumes Of Slag Or Fly Ash

Master'sMASTER OF ENGINEERIN

Response and failure mechanisms of structural member under high velocity impact

Ph.DDOCTOR OF PHILOSOPH

Chemopreventive Effects And Proteomic Analysis Of Myo Inositol Treatment On Human Prostate Cancer Cell Line (Du-145)

Prostate cancer remains the second most frequent diagnosed cancer in men and is the third leading cause of cancer related death, despite many available treatment options. The inefficiency of existing therapies and their adverse effects have led scientists to seek new treatments for this disease. The identification and development of new anti-proliferative agents for prostate cancer is a major innovation in treating this deadly disease. Although the synthetic compound Myo-inositol is widely used in cancer research, the actual anti-cancer function of these chemicals is still not well understood. This study was therefore intended to unveil the chemopreventive effects of Myo-inositol on prostate cancer cells (DU-145). The growth inhibitory effect and the IC50 value were demonstrated by Myo-inositol at 0.06 mg/ml (**p<0.05). It is suspected that cell deaths are related to apoptosis induction and cell-cycle arrest. Treatment with Myo-inositol has been further identified by induction of early and late apoptosis (***p<0.01). Apoptosis can also be detected using DNA fragmentation and Hoechst 33342 fluorescent dye stain analysis. Myo-inositol caused an alteration to the cell cycle regulation on DU-145 cell line at G0/G1 and S phase, respectively (***p<0.01). Protein identification results via 2D electrophoresis and LC-MS/MS analysis showed 19 and 23 proteins identified in control and Myo-inositol treated samples, respectively

Perceived Consequences of Unpredictable Fuel Hike in Bangladesh

The unpredictability of fuel hikes has become a significant concern for the people of Bangladesh. This study revealed the perceived consequences of unexpected fuel hikes among the people of Bangladesh. A mixed-method approach, such as interviews and focus group discussions, was used to collect data. The data were collected from different places in Dhaka city in Bangladesh. The findings of the study reveal that an unpredictable fuel hike has significant consequences for the people of Bangladesh. These consequences include an increase in transportation costs, a rise in the prices of goods and services, and a rise in the cost of living. The increase in fuel prices has triggered inflation, which has adverse impacts on the economy. Other potential consequences include a reduction in industrial output, a decrease in foreign investment, and an increase in unemployment rates. The majority of respondents were highly concerned about the unpredictable increase in fuel prices, and they expected the government to take necessary steps to stabilize fuel prices. The study suggests that a coordinated effort from the government, policymakers, and stakeholders is necessary to address this issue. This will alleviate the negative consequences of unpredictable fuel hikes in Bangladesh. Keywords: Fuel Hike, Inflation, Living Standard, Economic Condition, Social Instability DOI: 10.7176/JESD/14-12-05 Publication date:June 30th 202