Gait Solution For Hexapod Locomotion By Arduino

Robots are controlling today's tech-machines scenario and world is ready to accept the new trends the for useful operations. In some industries, a part of work which signify threat and consequently, very strict security rules e.g. some of the work in nuclear plant, where human can't go or its should be avoided as well as such condition such as underwater exploration even on terrain surface too where human can't go on defined destination or somehow it's difficult to reach on defined destination even in surface such as rock, mud, natural water flow, sometimes it's impossible to move for any huma

Hexapod: A Spider for Terrain and Obstacle Shunning by Arduino

Robots are controlling today's tech-machines scenario and world is ready to accept the new trends the for useful operations. In some industries, apart of work which signify threat and consequently, very strict security rules e.g. some of the work in nuclear plant, where human can't go or its should be avoided as well as such condition such as underwater exploration even on terrain surface too where human can't go on defined destination or somehow it's difficult to reach on defined destination even in surface such as rock, mud, natural water flow, sometimes it's impossible to move for any huma

Preparation and in vitro evaluation of Allopurinol-Gelucire 50/13 solid dispersions

The rate-limiting step to absorption of drugs from the gastrointestinal tract is often dissolution from the dosage form. Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with leukaemia, radiotherapy, anti-neoplastic agents. One of the major problems with allopurinol is that, it is practically insoluble in water, which results in poor bioavailability after oral administration. In the present study, solid dispersions of allopurinol were prepared by solvent evaporation method, kneading method, co-precipitation method, co-grinding method and closed melting method to increase its water solubility. In the present study amphiphilic carrier like gelucire 50/13 was used in the ratio of 1:1, 1:2 and 1:4. Prepared solid dispersions were characterized in the liquid state by phase solubility studies and in the solid state by Differential Scanning calorimetric analysis, Powder X-ray diffractometry and Fourier Transform Infrared spectroscopy. The aqueous solubility of allopurinol was preferential by the presence polymer with increasing concentration. Solid state characterizations indicated that allopurinol was present as an amorphous material and entrapped in polymer matrix.Mathematical modeling of in vitro dissolution data indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics primarily as Non-Fickian diffusion. Therefore, the current study showed that gelucire 50/13 has a significant solubilizing effect on allopurinol.Keywords: Allopurinol, gelucire 50/13, closed melting-method, co-grinding, dissolution study, powder X-ray diffraction analysi

Biopolymer catalysed synthesis of 6-methyl-4-phenylcarbamoyl-1, 2, 3, 4-tetrahydropyrimidine-2-ones and evaluation of their anti-bacterial and anti-tubercular activities

1ackground: An efficient one-pot biocatalysed ultrasound assisted synthesis of dihydropyrimidinones/thiones has been developed under solvent free conditions. Materials and Methods: The use of biodegradable, non toxic, agar-powder as a catalyst provide advantages like high yield, simple operation, mild reaction condition with short reaction time. 1,2,3,4-tetrahydropyrimidine-2-ones/thiones formed were characterized by mass and 1H NMR spectroscopy. Results: The dihydropyrimidinones substituted with electron donating groups like fluorine, hydroxy along with thienyl groups exhibited good antibacterial activity. The compounds exhibited favorable binding interactions with mycobacterium target protein H37Rv. Conclusion: 4-methoxy substituted dihydropyrimidinones derivative showed significant antituberculosis activity

A simple route towards next-gen green energy storage by fibre-based self-supporting electrodes and a truly solid polymer electrolyte

To meet the challenge of a green energy economy that could offer the chance to escape from our dependence on fossil fuels, the rapid development of materials science and technology is vital. Nowadays, advanced devices that convert and store energy are the focus of intensive research that is being carried out along various avenues and Lithium-ion batteries (LIBs) in combination with fuel cells and supercapacitors hold the promise for a clean solution for an electric future. Currently, there are a number of efforts underway to develop lithium cells by using renewable resources, to simplify the fabrication processes to lower the costs, and to use water as solvent to reduce the environmental impact. An increased attention is also devoted to the recycling of spent LIBs even though the assessment of the real balance between the economic and environmental impact of this process is still matter of debate. In this respect, a novel and original Li-ion cell architecture is here successfully developed for the first time by exploiting the use of carbonized cellulose nanofibrils as both conductive binder and current collector substrate. The cellulose nanofibrils are also used as a reinforcing agent for the preparation of an unconventional composite polymer electrolyte as separator. The truly solid lab-scale Li-ion cell, assembled in a “pouch cell”, demonstrates remarkably stable cycling characteristics upon prolonged cycling at ambient temperature. The outstanding results are obtained along with the implementation of a pilot line procedure, comprising the spray coating and water-based papermaking techniques. Noteworthy, the battery components after use can be fully recovered using paper recycling techniques, which will definitely open up a truly new way of conceiving advanced sustainable batteries