The Role of curcumin extract in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

Cyclophosphamide, a chemotherapeutic and immunosuppressive drug, has been linked to problems after bone marrow transplantation in the past. More recently, it has been demonstrated that cardiotoxicity limits the dose of cyclophosphamide, and cardiology is receiving more attention. Though the exact mechanism of cyclophosphamide-induced cardiotoxicity is unknown, oxidative and nitrative stress are suspected to play a role. As a result, the focus of this review is on antioxidants and how they can reduce or prevent cyclophosphamide-induced cardiotoxicity. It will place a special emphasis on the cardioprotective properties of naturally occurring, plant-derived antioxidants such as curcumin extract, which have recently attracted a lot of interest

Study of antioxidant effect of Curcuma longa L. phenolic extract, sodium selenite and vit. E on some physiological and biochemical criteria of white male rats treated with chromium picolinate

The current study was designed to determine the antioxidant effects of phenolic extract of Curcuma longa L. ,sodium selenite and vitamin E against oxidative stress induced by chromium picolinate in some physiological and biochemical criteria for the blood, some antioxidants and neurotransmitters of the brain on the adult male rats.  The study was conducted in the animal house of the Faculty of Science/University of Kufa on 70 animals of adult male rats aged 2.5-3 months and the weight of 200-250 gm. The results showed no significant change (p>0.05) in the average of body weight, body organ weight and liver enzymes in the rats treated with chromium picolinate only for the two periods of the experiment as well as the same results recorded in the animals treated with chromium picolinate with vitamin E and sodium selenite and chromium picolinate with the phenolic extract of Curcuma longa for six and eight weeks compared with control group. As it has been noted a significant decrease (p<0.05) in the antioxidants include superoxide dismutase, glutathione peroxidase and significant increase (p<0.05) in the malondialdehyde in the animals treated with chromium picolinate for the two period of administration compared with the control group also a significant decrease (p<0.05) in dopamine (DA) and a significant increase (p<0.05) on serotonin (5-HT) in the animals treated with chromium picolinate only in compared with control group. Moreover, the significant increase occurred (p<0.05) in the antioxidants superoxide dismutase and glutathione peroxidase levels and significant decrease(p<0.05) in malondialdehyde level in the animals treated by chromium picolinate separately with the phenolic extract of Curcuma longa, chromium picolinate with vitamin E and sodium selenite compared with the control group and the results showed a significant increase (p<0.05) in dopamine (DA) and significant decrease (p <0.05) in the serotonin (5-HT) in the groups mentioned above for a periods of six and eight weeks compared with control group.                                                                                                                                                                                                              The study conclude from that the phenolic extract of Curcuma longa, sodium selenite and vitamin E have effective antioxidants against oxidative stress induced by oral administration of chromium picolinate led to an improvement of the above criteria studied, compared with control group and the best results are recorded after treatment by the phenolic extract of Curcuma longa

Physiological study of NGAL and Cystatin C in chronic and acute kidney disease patients

Kidney disease is an important global health concern, affecting ~15% of the global population and typically associated with systemic disorders (e.g., diabetes). Increased incidence of kidney diseases and their progression to critical stages are facing many nations across the globe. The current study was performed with 65 male patients (20 with Acute kidney disease and 45 with chronic kidney disease, their mean age (44.38±14.59) years, who have visited the physician's consultancies and the kidney disease unit at Al-Sadder Teaching hospital in Al-najaf, Iraq, and 25 persons as a healthy control group their mean age (48.68±16.37) years, They were all Males with no prior medical history and no indications or symptoms of renal disease, diabetes, anemia, hypertension, thyroid illness, dyslipidemia, or obesity . The study was conducted from September 2021 to May 2022. Biomarker appropriate for kidney failure monitoring should have narrow biological variability Such as NGAL and Cystatin C Were biomarkers of tubular epithelial cells injury and pathogenesis of KD progression, it was predicted to be reflecting disease activity and kidney function. In this study, serum NGAL and Cystatin C levels were measured in patients and healthy groups.&nbsp

NGAL as a biomarker in chronic kidney disease

The current study was performed with 65 patients with Chronic kidney disease, their mean age (44.38±14.59) years, who have visited the physician's consultancies and the kidney disease unit at Al-Sadder Teaching hospital in Al-Najaf, Iraq, and 25 persons as a healthy control group their mean age (48.68±16.37) years. The study was conducted from September 2021 to May 2022. In this study, serum NGAL levels were measured in patients and healthy groups. It also assays the relationship between levels of these biomarkers with some hematological and biochemical parameters RBCs, Hb, PCV, Creatinine, Urea, GFR. The results revealed that there was a Significant decrease with mean± SD of RBCs, HGB, as well as PCV, (3.36±0.69 X106/ mm3), (8.99±1.76mg/dl), (28.47±4.2%) respectively of patients with kidney disease as compared with healthy groups (4.55±0.47 x 106mm3), (14.28±1.43 mg/dl), and (40.11±3.84 %) respectively. The results also shows significant difference (p-value&lt;0.05) decreased with mean± SD of eGFR in Kidney failure patients (13.42±13.83 ml/min/1.73 m2) as compared with healthy control group (114.12±12.49 ml/min/1.73 m2)