Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2'-deoxyguanosine, in rat colonic mucosa.

International audienceDextran sodium sulfate (DSS) given in drinking water can induce colonic inflammation and produce colorectal tumors in rodents, although it is not directly genotoxic. The hypothesis that DSS can produce free radicals and induce oxidative DNA damage in colonic mucosa has been tested. In rats fed for 2 days with water containing 3% and 6% DSS, colonic inflammation manifestations were recorded and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), a major biomarker of oxidative DNA damage, was assayed in colonic mucosa. As compared with control rats given pure water, inflammatory manifestations were seen in rats given DSS. At the same time, 8-oxodGuo levels in colonic mucosa were doubled (P < 0.001). These results suggest that formation of oxidative DNA damage in colonic mucosa depends on inflammation and maybe on the production of reactive oxygen species. This study shows that DSS can induce oxidative DNA damage within only 2 days, which could explain in part its carcinogenic properties

Un système d'acquisition de données pour l'analyse en ligne des photographies de grandes chambres à bulles

Ce travail présente le système d'analyse des clichés de grandes chambres à bulles telles que Gargamelle et BEBC, réalisé au Groupe de Chambre à Bulles à Liquide Lourd à l'aide d'appareils de projection mis en ligne sur ordinateur CDC 1700. Ce travail présente les caractéristiques générales de ces appareils ainsi que celles de l'ordinateur et développe la conception et les fonctions des programmes d'analyse des photographies : prémesures, mesures et gestion des données. L'ensemble du système d'acquisition de données fonctionne dans un contexte de multiprogrammation en temps réel

Assessment of biogaspotentialhazards

International audienceBiogas produced from anaerobic fermentation of organic substances represents an alternative renewable energy source. Its utilization would contribute to substantial reduction of the solid waste volume in land-filling and incineration. Biogas so produced could be utilized on site or it could be injected into the natural gas distribution network. Microbiological and chemical compositions of different biogas types were determined in order to conduct qualitative and quantitative risk assessments of the potential health hazards associated with biogas use for cooking. Biogas types that could be allowed for injection in the natural gas pipelines were listed with recommendations, while outlining the European biogas injection policy. Results indicated that the injection of the processed biogas in the distribution network did not present any additional chemical or microbiological risk to consumers when compared to natural gas, provided that the biogas resulted from the fermentation of non-dangerous waste. However, since this study did not examine the microbiological and chemical composition of biogas originating from wastewater sludges and/or industrial wastes, the injection of this type of biogas into the gas distribution network should not be allowed unless a similar risk evaluation study is conducted for each case

Un système d'acquisition de données pour l'analyse en ligne des photographies de grandes chambres à bulles

This work presents the analysis system of large bubble chamber pictures, such as from Gargamelle, BEBC, realized in the heavy liquid bubble chamber group with scanning and measurement stations on-line with a CDC 1700 computer. This work deals with the general characteristics of these stations and of the computer, and emphasises the conception and functions of the analysis programmes : scanning, measurement and data processing. The data acquisition system runs in a context of real time multiprogrammation.Ce travail présente le système d'analyse des clichés de grandes chambres à bulles telles que Gargamelle et BEBC, réalisé au Groupe de Chambre à Bulles à Liquide Lourd à l'aide d'appareils de projection mis en ligne sur ordinateur CDC 1700. Ce travail présente les caractéristiques générales de ces appareils ainsi que celles de l'ordinateur et développe la conception et les fonctions des programmes d'analyse des photographies : prémesures, mesures et gestion des données. L'ensemble du système d'acquisition de données fonctionne dans un contexte de multiprogrammation en temps réel