Towards a Pharmacophore for Amyloid

Diagnosing and treating Alzheimer's and other diseases associated with amyloid fibers remains a great challenge despite intensive research. To aid in this effort, we present atomic structures of fiber-forming segments of proteins involved in Alzheimer's disease in complex with small molecule binders, determined by X-ray microcrystallography. The fiber-like complexes consist of pairs of β-sheets, with small molecules binding between the sheets, roughly parallel to the fiber axis. The structures suggest that apolar molecules drift along the fiber, consistent with the observation of nonspecific binding to a variety of amyloid proteins. In contrast, negatively charged orange-G binds specifically to lysine side chains of adjacent sheets. These structures provide molecular frameworks for the design of diagnostics and drugs for protein aggregation diseases

Application of GIS-Based Construction Engineering: An Electronic Document Management System

This paper describes the implementation of a GIS to provide decision support for successfully monitoring the movements and storage of materials, hence ensuring that finished products travel from the point of origin to the destination construction site through the supply-chain management (SCM) system. This system ensures the efficient operation of suppliers, manufacturers, and distributors by determining the shortest path from the point of origin to the final destination to reduce construction costs, minimize time, and enhance productivity. These systems are essential to the construction industry because they reduce costs and save time, thereby improve productivity and effectiveness. This study describes a typical supply-chain model and a geographical information system (GIS)-based SCM that focuses on implementing an electronic document management system, which maps the application framework to integrate geodetic support with the supply-chain system. This process provides guidance for locating the nearest suppliers to fill the information needs of project members in different locations. Moreover, this study illustrates the use of a GIS-based SCM as a collaborative tool in innovative methods for implementing Web mapping services, as well as aspects of their integration by generating an interactive GIS for the construction industry platform

Therapy of Hemorrhoid grade 4 based on Iranian Traditional Medicine: Case Report

Introduction: According to opinion of the scientists of Iranian traditional medicine, hemorrhoid is anal lump that is created on the vessels and its factor is soda humor. Treatment of this disease in Iranian traditional medicine is to clear excess soda humor from the body and prevent its formation through modifying the organs involved in its production and finally remove soda humor from the anal vessels. Case report: Patient is a 69-year-old man with basic tempered of phlegm and yellow bile that had external 6 Pack Level 4 hemorrhoids without bleeding. According to Iranian traditional medicine classification, hemorrhoid was from palm group. The patient was completely cured during the three sessions of 6 weeks. Medical interventions such as soda reducing diet, vasoconstrictors (hemorrhoid constricting) agents, hepatic clearance and laxatives were used. Also, hirudotheraphy was used for removing soda from the side of anal. Discussion: With the expansion of education and research in the field of Iranian traditional medicine therapies can be developed based on traditional medicine, effective, non-invasive and low cost according to individual patient basis (based on the patient's tempered which is important in the quality of life. Therefore, it is necessary to do more researches to consider measures and treatments based on Iranian traditional medicine in order the scientific evidences continue to grow