Use and Awareness of Open Access Legal Information Resources by the Law College Students in Western Maharashtra: An Empirical Study in India

This article discussed about the use and awareness about the open access legal resources in the state of western Maharashtra region in India. Researcher tried to find out the awareness, sources of awareness, among law students about open access legal resources i.e. JUDIS (Judgment Information System), Bombay High Court Judges Library, Supreme Court Judges Library (SUPLIS), India Code Information System, Indian Kanoon Legal Information Institute of India. Then researchers revealed the data about the frequency and purpose of using these resources. Research finds out the user perception about quality of open access resources from users’ point of view and subsequently, discussed the satisfaction level of users and problems being faced by the students during use of these resources. Study reveals that (44.5%) respondents were from LLB program and 60.7% respondents were aware about these resources. It also reveals that (65%) respondents were using India kanoon, 77 (20.8%) users using National Digital Library portal, 74 (19.9%) respondents using Bombay High Court Judgments, 67 (18.1%) Supreme Court Judges Library. social media, Teachers and Library Staff are main sources of knowledge. 191 (46.5%) responses mentioned as Less awareness about open access legal information resources. Henceforth, law librarians should be taking initiatives for making awareness among law students by conducting more library orientations and extra library lectures and 44.9%) respondents replied with good comment for quality of open access resources in users point view and 61.7% respondents were satisfied. Most of users using open access resources by as and when required

Google Originality Test: An Instrument for Research Integrity in Higher Educational Institutes

The paper explains the importance of research for development of society. It describes meaning of plagiarism, types of plagiarism and also discussed commercial and open-source plagiarism software which are available in the market. More importantly it talks about Google-Originality check process, Its Advantages and disadvantages of originality check, Importance of plagiarism in research or correlation of plagiarism and research methodology and its implementation and use for research integrity in higher educational institutes. This paper will be useful for teachers, students and librarians for testing the plagiarism report and making the research integrity. This is a best tool for the beginners

Intelligent Compaction Analyzer System for Vibratory Road Rollers using ARM Microcontroller and Data Updation on Server using Android Application

This paper provides an introduction to intelligent compaction for road construction and was developed as a resource for new users interested in understanding some of the applications and benefits of implementing this technology. Any agencies are into this business faced with the same challenges of reduced staff and having fewer people on site so more time and effort that is required for some of the quality assurance testing. It’s just not available anymore, for that we need to find ways to accomplish with less staff time and may be the greater coverage of area because there is less number of knowledgeable people to do the inspection. One of our main aims to evolve away from the nuclear density gauges. We think that the natural evolvement for that would be the Intelligent Compaction Analyzer System

Transforaminal percutaneous endoscopic lumbar discectomy versus microdiscectomy: an Indian rural experience

Background: The objective of the study was to compare surgical outcome of micro-discectomy with transforaminal percutaneous endoscopic lumbar discectomy for single level lumbar disc herniation in Indian rural population.Methods: Retrospective comparative study was designed during the period of October 2012 to June 2015, patients in the age group of 22-75 years with unremitting sciatica with/without back pain, and/or a neurological deficit that correlated with appropriate level and side of neural compression as revealed on MRI, with single level lumbar disc herniation who underwent either microdiscectomy or TPELD were included in the study. Patients were assessed on visual analogue scale (VAS) for back and leg pain, modified macnabs criteria, the Oswestry Disability Index (ODI).Results: Group I (MD) included 44 patients and Group II (TPELD) included 20 patients. Significant improvement was seen in claudication symptom post-operatively in both MD and TPELD. Mean operating time was significantly shorter in MD group (1.11 hrs vs. 1.32 hrs; p<0.01). According to modified MacNab's criteria, outcome were excellent (81.8%), good (9.09%) and fair (9.09%) in MD. Similarly, in TPELD, 80%, 15% and 5% patients had excellent, good and fair outcome respectively. In both groups, no one had a poor outcome. Thus, overall success rate was 100% in the study.Conclusions: TPELD and MD have comparable post-operative outcome in most of the efficacy parameters in Indian rural patients undergoing treatment of single level lumbar disc herniation. Additionally, TPELD offers distinct advantages such as performed under local anaesthesia, preservation of structure, lesser post-operative pain and early mobilization and discharge from hospital

Dissolution Rate Enhancement of Lansoprazole Tablet in Hydrophilic Carrier Solid Dispersions by Solvent Evaporation Methods

Solid dispersion technique has been developed for improving solubility of water-insoluble drugs, aiming to achieve a better oral bioavailability. The objectives of present investigation is to improve the solubility and rate of dissolution of poorly aqueous soluble drug lansoprazole by preparing solid dispersion with hydrophilic carrier Poly Ethylene Glycol 6000, hydroxy propyl methyl cellulose, Polyvinyl pyrrolidone by using solvent evaporation method and selecting the best solid dispersion. The drug and excipient compatibility study of selected solid dispersion was performed by FTIR and DSC. This study showed no interaction in drug and carrier. The designed granulation method was employed to prepare solid dispersion tablets and the formulation was optimized through investigating the dissolution behaviours. The results indicated PEG and Polyvinyl pyrrolidone in combination of solid dispersion showed the best effect both on physical characterizations and dissolution studies. Furthermore, all type of solid dispersions significantly improved the dissolution rates when compared to pure drug and its corresponding physical mixture (PM). All the evaluations were performed and complies with the pharmacopoeial standards. The formulation F7 showed 98.88% of cumulative drug release within 8 min with zero order release pattern. The solid dispersion tablets prepared in simplified tableting method exhibited better operability, stability and dissolution behaviour than the tablets prepared in traditional ways, which brought more opportunities to solid dispersion technique for industrial productio

FORMULATION AND EVALUATION OF MICROSPONGE GEL FOR TOPICAL DELIVERY OF ANTIFUNGAL DRUG

Objective: The purpose of present study aims to design novel drug delivery system containing oxiconazole nitrate microsponges and to prepare microsponge gel. Oxiconazole nitrate is an antifungal drug used in the treatment of fungal infection having a poor aqueous solubility, side effects and adverse reactions. The microsponge delivery system is unique technology for controlled release of active agents. Methods: The microsponges were prepared by quasi-emulsion solvent diffusion method by using polymer eudragit S-100 and eudragit L-100. All the formulated microsponges were subjected for various evaluation parameters such as production yield, encapsulation efficiency, particle size analysis and in vitro drug release study. The optimised microsponge formulation F3 and F9 were further formulated as gel formulation for topical delivery. Prepared gel was evaluated for physical parameters like pH, spreadability, viscosity, drug content and in vitro diffusion study and compared with the marketed formulation.Results: The Fourier transform infrared radiation measurement (FTIR) and Differential scanning colorimetry (DSC) of drug and excipient confirm compatibility. Results revealed that quasi-emulsion solvent diffusion method is a suitable technique for the preparation of microsponges as most of the formulations were discrete and spherical in shape with a good production yield of 61.44% to 80.45% and The highest drug release for F3 and F9 formulation was found to be 87.77 % and 83.24 % respectively for the 8 h. The microsponge gel formulation MGI (F3) showed the controlled release of oxiconazole nitrate for 12 h. The drug release data of optimised batch MGI (F3) were fitted into different kinetic models and showed that the drug release from gel formulation follows zero order release.Conclusion: As compared to conventional formulation, the prepared microsponge gel are expected to remain on the skin for a longer time, gradually releasing their contents over the time. Hence, oxiconazole nitrate microsponges and microsponge gel prepared in this study are promising as being more useful than conventional formulation therapy

PREPARATION AND EVALUATION OF MICROEMULSION CONTAINING ANTIHYPERTENSIVE DRUG

Objective: The aim of the present study was to design novel drug delivery system containing ramipril microemulsion. Ramipril is an antihypertensive drug having very low aqueous solubility and bioavailability. Ramipril microemulsion could be used as a possible alternative to the traditional oral formulation to improve dissolution rate and hence its bioavailability with avoidance of the first-pass metabolism. Methods: The microemulsion existence region was determined by constructing pseudoternary phase diagram and prepared by using four components orange oil, tween 80 as a surfactant, propylene glycol as co-surfactant and distilled water as the aqueous phase. The water titration method was employed for its determination. All formulated microemulsion were subjected for visual inspection, centrifugation and stability test. The all stable formulations were selected for further study. The optimized microemulsion formulation B-9 was subjected for various evaluation parameters such as, visual inspection, stability studies, pH, viscosity measurements, electrical conductivity, content uniformity and dye solubility test. Results: Results revealed that construction of phase diagram and use of phase titration method was a suitable technique for the preparation of microemulsion as most of the formulations were transparent. It was found that the best microemulsion result was found for ratio 2:1. The results of stress tests conclude that the optimized formulation was both physically and chemically stable for 8 mo. Also, The Fourier transform infrared (FTIR) radiation measurement and Differential scanning calorimetry (DSC) of optimized formulation indicate the compatibility of ramipril with orange oil, surfactant-tween 80 and cosurfactant-propylene glycol. From electrical conductivity 0.283 σ and staining test the prepared optimized formulation B-9 was found to be o/w type of microemulsion. The optimized B-9 formulation showed good viscosity 13.52±0.01cps and pH 3.21±0.02 with highest drug content uniformity was found to be 84.98±0.02 %. Conclusion: In the present study a satisfactory attempt was made to formulate a novel o/w microemulsion of ramipril which improves the gastrointestinal absorption by raising its water solubility and hence oral bioavailability is also enhanced.Â&nbsp

FORMULATION AND EVALUATION OF GASTRORETENTIVE TABLETS OF ANTIULCER DRUG

ABSTRACTGastroretentive floating drug delivery system is utilised to target drug release in the stomach or to the upper part of intestine. Lansoprazole is proton pump inhibitor intended for oral administration used as antiulcer agent. The present investigation involved formulation and evaluation of Gastroretentive floating tablets of Lansoprazole for prolongation of gastric residence time with a view to deliver the drug at sustained and controlled manner in gastrointestinal tract. The tablets of Lansoprazole were prepared by direct compression method using gas generating agent and different polymer combinations (HPMCK4M, HPMC K100M, Psyllium husk) . The prepared tablets of Lansoprazole were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, swelling index, in-vitro dissolution study. The varying concentration of gas generating agent and polymers were found to affect on in-vitro drug release, floating lag time and swelling index. In vitro drug release of floating Gastroretentive tablet of Lansoprazole shown that the formulation F2 was found to be the best formulation as it releases 97.9% Lansoprazole in a controlled manner for extended period of time (upto 12 hrs.)Keywords: Lansoprazole, Gastroretentive, floating tablet, total floating time