— Étude des spectres de vibration des composés d’addition de l’éther méthylique et du fluorure de bore entre 1 500 ET 50 cm

Les spectres infrarouges et RAMAN des six composés de coordination (CH3)2O — 11BF3, CH3OCD3 — 11BF3, (CD3)2O — 11BF3, (CH3)2O — 10BF3, CH3OCD3 — 10BF3 et (CD3)2O — 10BF3 ont été enregistrés dans la région 50-1 500 cm-1. L’attribution proposée est basée sur les déplacements de fréquences dus à la substitution isotopique, la comparaison avec les molécules d’éther libres et la polarisation des raies RAMAN. Une interaction importante entre les vibrations de squelette de l’éther et les mouvements symétriques du groupe OBF3 est mise en évidence

N° 11. — Spectres infrarouges de 4 000 à 600 cm

Les spectres infrarouges des composés d’addition (Et2O)2 — MgBr2, Et2O — ZnCl2, Et2O — AlX3 et (CH3CD2)2O — AlX3 (X = Cl ou Br) ont été enregistrés et analysés entre 4 000 et 600 cm–1. Une attribution basée sur la comparaison des spectres des complexes avec celui de l’éther libre vitreux est proposée. Elle montre que les vibrations les plus perturbées par la complexation sont les vibrations de valence mettant en jeu les liaisons CH des groupements CH2 et CO

Conversions and complications of laparoscopic treatment of gastroesophageal reflux disease

BACKGROUND: It is now known that laparoscopic surgery is associated with less discomfort and less pain during the patient's postoperative course. Laparoscopic treatment of gastroesophageal reflux disease (GERD) is technically feasible. The advantages of tins minimally invasive surgical route seem well adapted to a basically functional surgery. However, it is important to know whether laparoscopic access adds a specific risk to this type of surgery. PATIENTS AND METHODS: A retrospective survey was conducted among members of the Formation for the Development of Laparoscopic Surgery (FDCL) group during 1993. A form was filled in anonymously for each patient who had had either a conversion or a postoperative complication following a laparoscopic procedure for GERD. Items concerned preoperative workup, technical details of surgery, and postoperative course. Another form was used to ascertain how many surgical procedures for GERD had been performed during the same period, either laparoscopically or via an elective laparotomy. Nineteen surgeons from the FDCL group took part in the study. From 1991 to 1993, 758 patients underwent a laparoscopic procedure for GERD, while during the same period 38 patients underwent an elective laparotomy. RESULTS: In the laparoscopic group, there were 294 Nissen, 334 Nissen-Rossetti, and 106 Toupet procedures, and 24 Angelchik prosthesis placements. No deaths occurred. The operation had to he converted to an open procedure in 32 cases (4.2% conversion rate). In 7 cases the conversion was due to an intraoperative complication, whereas in 25 cases the conversion was done because of technical difficulties. In 6 cases an intraoperative complication was treated laparoscopically without conversion. Thirty postoperative complications were recorded (morbidity 4%), leading to a reoperation in 12 cases. Five major complications were observed: 2 esophageal perforations, 2 gastric perforations, and 1 bowel perforation. CONCLUSION: These results compare favorably with those of open surgery and suggest that laparoscopic treatment of GERD is as safe as open surgery when performed by a surgeon experienced in laparoscopy.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Long-term Temozolomide Treatment Induces Marked Amino Metabolism Modifications and an Increase in TMZ Sensitivity in Hs683 Oligodendroglioma Cells1

Gliomas account for more than 50% of all primary brain tumors. The worst prognosis is associated with gliomas of astrocytic origin, whereas gliomas with an oligodendroglial origin offer higher sensitivity to chemotherapy, especially when oligodendroglioma cells display 1p19q deletions. Temozolomide (TMZ) provides therapeutic benefits and is commonly used with radiotherapy in highly malignant astrocytic tumors, including glioblastomas. The actual benefits of TMZ during long-term treatment in oligodendroglioma patients have not yet been clearly defined. In this study, we have investigated the effects of such a long-term TMZ treatment in the unique Hs683 oligodendroglioma model. We have observed increased TMZ sensitivity of Hs683 orthotopic tumors that were previously treated in vitro with months of progressive exposure to increasing TMZ concentrations before being xenografted into the brains of immunocompromised mice. Whole-genome and proteomic analyses have revealed that this increased TMZ sensitivity of Hs683 oligodendroglioma cells previously treated for long periods with TMZ can be explained, at least partly, by a TMZ-induced p38-dependant dormancy state, which in turn resulted in changes in amino acid metabolism balance, in growth delay, and in a decrease in Hs683 oligodendroglioma cell-invasive properties. Thus, long-term TMZ treatment seems beneficial in this Hs683 oligodendroglioma model, which revealed itself unable to develop resistance against TMZ

Abstracts of the 6th FECS Conference 1998 Lectures

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