Unspeakable Acts: Women, Art, and Violence in the 1970s

Review of Unspeakable Acts: Women, Art, and Violence in the 1970s, Reviewed January 2020 by Jacqueline Fleming, Visual Literacy and Resources Librarian, Herman B. Wells Library, Indiana University, [email protected]

Lives of the Artists Series

Review of Lives of the Artists Series, Reviewed November 2020 by Jacqueline Fleming, Visual Literacy and Resources Librarian, Indiana University-Bloomington, [email protected].

A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts.

Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for linking molecular signatures to clinical data. However, performing NGS on FFPE samples is limited by poor RNA purification methods. To address this hurdle, we developed an improved methodology for extracting high-quality RNA from FFPE samples. By briefly integrating a newly-designed micro-homogenizing (mH) tool with commercially available FFPE RNA extraction protocols, RNA recovery is increased by approximately 3-fold while maintaining standard A260/A280 ratios and RNA quality index (RQI) values. Furthermore, we demonstrate that the mH-purified FFPE RNAs are longer and of higher integrity. Previous studies have suggested that pancreatic ductal adenocarcinoma (PDAC) gene expression signatures vary significantly under in vitro versus in vivo and in vivo subcutaneous versus orthotopic conditions. By using our improved mH-based method, we were able to preserve established expression patterns of KRas-dependency genes within these three unique microenvironments. Finally, expression analysis of novel biomarkers in KRas mutant PDAC samples revealed that PEAK1 decreases and MST1R increases by over 100-fold in orthotopic versus subcutaneous microenvironments. Interestingly, however, only PEAK1 levels remain elevated in orthotopically grown KRas wild-type PDAC cells. These results demonstrate the critical nature of the orthotopic tumor microenvironment when evaluating the clinical relevance of new biomarkers in cells or patient-derived samples. Furthermore, this new mH-based FFPE RNA extraction method has the potential to enhance and expand future FFPE-RNA-NGS cancer biomarker studies

Do dance floor force reduction and static stiffness represent dynamic floor stiffness during dance landings?

Dance training on floors that are not \u27sprung\u27 are assumed to have direct implications for injury. Standards for dance floor manufacture in Europe and North America quantify floor force reduction by measuring the impact forces of drop masses. In addition, many studies of human mechanical adaptations to varied surfaces, have quantified test surfaces using measures of static stiffness. It is unclear whether these methods for the measurement of floor mechanical properties actually reflect dancer requirements or floor behaviour under dancer loading. The aim of this study was to compare the force reduction, static stiffness and dynamic stiffness of a range of dance floors. Dynamic stiffness was measured during dancers performing drop landings. Force reduction highly correlated (p= 0.086) with floors of moderate dynamic stiffness, but was less accurate for high and low stiffness floors. Static stiffness underestimated the dynamic stiffness of the floors. Measurement of floor force reduction using European sports surface standards may provide an accurate representation of dynamic floor stiffness when under load from dancers performing drop landings. The discrepancy between static and dynamic stiffness may be explained by the inertial characteristics of the floor and the rapid loading of the floors during dancer landings. The development of portable systems for measuring floor behaviour under human loads using modern motion capture technologies may be beneficial for improving the quantification of dance floor mechanical properties

Focusing Our Attention on Socially Responsive Professional Education to Serve Ethnogeriatric Populations With Neurogenic Communication Disorders in the United States

Purpose: This viewpoint discusses a plausible framework to educate future speech-language pathologists (SLPs) as socially responsive practitioners who serve and advocate for the burgeoning vulnerable ethnogeriatric populations with neurogenic communication disorders. Method: We provide an overview of the demographic, epidemiological, and biopsychosocial context that supports the implementation of equity-based, population-grounded educational approaches for speech-language pathology services in ethnogeriatric neurorehabilitation caseloads and discuss a plausible perspective based on the educational social determinants of health (SDOH) framework by the National Academies of Sciences, Engineering, and Medicine. Results: The NASEM\u27s three-domain SDOH educational perspective integrates education, community, and organization to create a self-reinforcing pedagogical coproduction that, grounded in the synergized partnerships of educational institutions, engaged communities, and organizational leadership, aims to address systemic drivers of health perpetuating ethnoracial disparities in health, care, and outcomes. Conclusion: Exponentially growing vulnerable ethnogeriatric populations with age-related neurogenic communication disorders warrant the implementation of health equity education strategies to train technically prepared, socially conscious SLPs as service providers and advocates

An Economic Evaluation of Commercial Paddlefish (Polydon spathula) Production

Potential changes in the tobacco program have prompted research of aquaculture crops in Kentucky. Using a dynamic, programming model, this paper evaluates two methods for producing pond-raised paddlefish to assess if either method is economically viable in Kentucky. Results indicate that a polyculture system with catfish is profitable.Key Words: Aquaculture, dynamic programming, paddlefish, production economics

2014 Massachusetts Family Impact Seminar: A Lot On Our Plate; Chronic Health Threats in Massachusetts

A Lot on Our Plate: Chronic Health Threats in Massachusetts is the fifth Massachusetts Family Impact Seminar, and is designed to emphasize a family perspective in policymaking on issues related to childhood obesity, cardiovascular disease, and type 2 diabetes. In general, Family Impact Seminars analyze the consequences an issue, policy, or program may have for families

Black students in U.S. higher education: Toward improved access, adjustment, and achievement

This paper seeks to broaden our knowledge and understanding of black student experiences in U.S. higher education over the past 20 years. Toward this end, I analyze black student enrollment/earned degree trends in the state of Michigan during the 1965–80 period; examine the institutional experiences of black students who enrolled as freshmen at the University of Michigan between 1975 and 1983; and assess the correlates of access, adjustment, and achievement of 700 black college students who attended six predominantly white public institutions in 1981. The analyses out across four different levels of U.S. higher education (national, state, institutional, and individual) and shed considerable light not only on black student experiences but also those of other minority and white students as well. Based on the result of the multidimensional analyses, I set forth an agenda for action to improve the status of blacks in higher education.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43873/1/11256_2005_Article_BF01112008.pd