7 research outputs found
Post-Hospitalization Experiences Of Older Adults Diagnosed With Diabetes: “It Was Daunting!”
- Publication venue
- 'Information Bulletin on Variable Stars (IBVS)'
- Publication date
- 01/01/2018
- Field of study
Multimorbidity combined with geriatric syndromes in older adults with diabetes exacerbate their risks for poor post-discharge outcomes. The purpose of this study was to examine self-described hospital-to-home transition challenges encountered by older adults with a diagnosis of diabetes within the first 30 days following discharge. The qualitative responses for this paper emerged from a larger mixed methods study (n = 96) in which participants provided free responses specifying transition challenges during follow-up telephone interviews on the 7th day (n = 67) and 30th day (n = 55) post-discharge. Using inductive content analysis techniques four major themes emerged: a) “The daily stuff is difficult”; b) engineering care at home is complex; c) “life is very difficult”; and d) managing complex health problems is difficult. Findings suggest existing system-level metrics such as readmission rates fail to capture the complex and dynamic interplay of personal, family and social factors which complicate hospital-to-home transitions of older adults with pre-existing diabetes
Post-hospitalization experiences of older adults diagnosed with diabetes: “It was daunting!”
- Author
- American Diabetes Association
- American Diabetes Association
- American Diabetes Association
- American Geriatrics Society Expert Panel on the Care of Older Adults with Diabetes Mellitus
- American Geriatrics Society on Care of Older Adults with Multimorbidity
- Angeline Bushy
- Auerbach
- Borson
- Byrne
- Callahan
- Centers for Disease Control and Prevention
- Coleman
- Coleman
- De Berardis
- Denise Gammonley
- Elo
- Enguidanos
- Fera
- Freund
- Gitlin
- Golden
- Gonsalves-Bradley DCL
- Goodman
- Gorina
- Greysen
- Jacqueline B. La Manna
- Kangovi
- Kangovi
- Kim
- Krumholz
- LaManna
- Maloney
- Marengoni
- Meleis
- Meleis
- Miller
- Morse
- National Transitions of Care Coalition NToC
- Naylor
- Naylor
- Naylor
- Neiterman
- Nicolucci
- Parker
- Perry
- Powers
- Quiñones
- Rafferty
- Reinhard
- Romagnoli
- Rubin
- Rubin
- Schneider
- Schumacher
- Shah
- van Walraven
- van Walraven
- Weiss
- Wen
- Wier
- Young-Hyman
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Multimorbidity combined with geriatric syndromes in older adults with diabetes exacerbate their risks for poor post-discharge outcomes. The purpose of this study was to examine self-described hospital-to-home transition challenges encountered by older adults with a diagnosis of diabetes within the first 30 days following discharge. The qualitative responses for this paper emerged from a larger mixed methods study (n = 96) in which participants provided free responses specifying transition challenges during follow-up telephone interviews on the 7th day (n = 67) and 30th day (n = 55) post-discharge. Using inductive content analysis techniques four major themes emerged: a) “The daily stuff is difficult”; b) engineering care at home is complex; c) “life is very difficult”; and d) managing complex health problems is difficult. Findings suggest existing system-level metrics such as readmission rates fail to capture the complex and dynamic interplay of personal, family and social factors which complicate hospital-to-home transitions of older adults with pre-existing diabetes
Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17\u2009458 subjects
- Author
- 6zkara \uc7igdem
- \u160terbov\ue1 Katalin
- Abbott Liam E.
- Afawi Zaid
- Andrade Danielle M.
- Annesi Grazia
- Arslan Mutluay
- Auce Pauls
- Auvinen Pia
- Bahlo Melanie
- Balestrini Simona
- Bari\u161ic Nina
- Bauer J\ufcrgen
- Baum Larry W.
- Baykan Bet\ufcl
- Bebek Nerses
- Becker Felicitas
- Bellows Susannah T.
- Bellows Susannah T.
- Bennett Caitlin A.
- Berkovic Samuel F.
- Bianchini Claudia
- Bisulli Francesca
- Blatt Ilan
- Borggr\ue4fe Ingo
- Braatz Vera
- Brockmann Knut
- Buono Russell J
- Burgess Rosemary
- Caglayan S. Hande
- Canafoglia Laura
- Canavati Christina
- Castellotti Barbara
- Cavalleri Gianpiero L.
- Cavalleri Gianpiero L.
- Cerrato Felecia
- Cheng Feixiong
- Cherny Stacey S.
- Chung Seo-Kyung
- Churchhouse Claire
- Ciullo Valentina
- Cossette Patrick
- Cossette Patrick
- Cotsapas Chris
- Daly Mark J.
- De Jonghe Peter
- Delanty Norman
- Dennig Dieter
- Depondt Chantal
- Depondt Chantal
- Devinsky Orrin
- Dixon-Salazar Tracy
- Dlugos Dennis J.
- Dlugos Dennis J.
- Dlugos Dennis J.
- Doccini Viola
- Doherty Colin P.
- El-Naggar Hany
- Elger Christian E.
- Ellis Colin A.
- Feng Yen-Chen Anne
- Ferraro Thomas N
- Franceschetti Silvana
- French Jacqueline A.
- French Jacqueline A.
- Freyer Catharine
- Gagliardi Monica
- Gallati Sabina
- Gambardella Antonio
- Gili Tommaso
- Goldstein David B.
- Granata Tiziana
- Grikiniene Jurgita
- Guerrini Renzo
- Gundogdu-Eken Asli
- Gupta Namrata
- H\ue4usler Martin
- Hakonarson Hakon
- Hakonarson Hakon
- Haryanyan Garen
- Hegde Manu
- Heinzen Erin L.
- Helbig Ingo
- Helbig Katherine L.
- Hengsbach Christian
- Howrigan Daniel P.
- Howrigan Daniel P.
- Iacomino Michele
- Inoue Yushi
- Johns Esther C.
- Johnson Michael R.
- K\ue4lvi\ue4inen Reetta
- Kamalakaran Sitharthan
- Kanaan Moien
- Kara Bulent
- Kesim Yesim
- Khankhanian Pouya
- King Chontelle
- Klein Karl Martin
- Kluger Gerhard
- Knake Susanne
- Korczyn Amos D.
- Korinthenberg Rudolf
- Kousiappa Ioanna
- Krause Roland
- Krestel Heinz
- Krey Ilona
- Kunz Wolfram S.
- Kurlemann Gerhard
- Kurlemann Gerhard
- Kuzniecky Ruben I.
- Kuzniecky Ruben I.
- Kwan Patrick
- Kwan Patrick
- Kwan Patrick
- La\u161\u161uthov\ue1 Petra
- Labate Angelo
- Lal Dennis
- Lal Dennis
- Lehesjoki Anna-Elina
- Lemke Johannes R.
- Lerche Holger
- Leu Costin
- Licchetta Laura
- Linnankivi Tarja
- Lo Warren
- Lowenstein Daniel H.
- Lui Colin H. T.
- M\ufcller-Schl\ufcter Karen
- Macdonald Alexandra
- Madeleyn Rene
- Madia Francesca
- Maisch Ana F.
- Mameniskiene Ruta
- Mancardi Maria Margherita
- Manna Lorella
- Marini Carla
- Marson Anthony G.
- Marson Anthony G.
- May Patrick
- Mayer Thomas
- McCormack Mark
- McKenna Kevin
- Mei Davide
- Minardi Raffaella
- Mo Kelly
- Montomoli Martino
- Mountier Emily
- Muccioli Lorenzo
- Muhle Hiltrud
- N\ufcrnberg Peter
- Neale Benjamin M.
- Niestroj Lisa-Marie
- O\u2019Brien Terence J.
- Palotie Aarno
- Papacostas Savvas S.
- Parrini Elena
- Pendziwiat Manuela
- Perez-Palma Eduardo
- Petrovski Slav\ue9
- Petrovski Slav\ue9
- Pickrell William O.
- Pippucci Tommaso
- Piras Fabrizio
- Piras Federica
- Poduri Annapurna
- Powell Robert
- Praninskiene Ruta
- Privitera Michael
- Rademacher Annika
- Rademacher Michael
- Rau Sarah
- Rees Mark I.
- Regan Brigid M.
- Regan Brigid M.
- Reif Philipp S.
- Rosenow Felix
- Saarela Anni
- Saarentaus Elmo
- Sadleir Lynette G.
- Sadoway Tara R.
- Salman Baris
- Salpietro Vincenzo
- Samaitiene Ruta
- Schachter Steven
- Schankin Christoph J.
- Scheffer Ingrid E.
- Schneider Natascha
- Schreiber Herbert
- Schubert-Bast Susanne
- Schulze-Bonhage Andreas
- Sedl\ue1ckov\ue1 Lucie
- Shain Catherine
- Sham Pak C.
- Sheidley Beth R.
- Shilling Hannah
- Shukralla Arif
- Sills Graeme J.
- Sisodiya Sanjay M.
- Sisodiya Sanjay M.
- Spalletta Gianfranco
- Sperling Michael R.
- Stamberger Hannah
- Steinhoff Bernhard J.
- Stephani Ulrich
- Stevelink Remi
- Stewart Randy
- Stipa Carlotta
- Striano Pasquale
- Striano Pasquale
- Suzuki Toshimitsu
- Tanteles George A.
- Tashman Katherine
- Tinuper Paolo
- Todaro Marian
- Topaloglu Pinar
- Tumiene Birute
- Turkdogan Dilsad
- Ugur-Iseri Sibel
- Utkus Algirdas
- van Baalen Andreas
- Vari Maria Stella
- Vetro Annalisa
- Vlckov\ue1 Mark\ue9ta
- von Spiczak Sarah
- Weber Yvonne G.
- Weckhuysen Dorien
- Weckhuysen Sarah
- Wolking Stefan
- Y\ufccesan Emrah
- Yamakawa Kazuhiro
- Yapici Zuhal
- Yis Uluc
- Zagaglia Sara
- Zara Federico
- Zhou Yadi
- Zsurka G\ue1bor
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations
- Author
- 6zkara \uc7i\u11fdem
- \u160t\u11brbov\ue1 Katalin
- Abbott Liam E.
- Abou\u2010Khalil Bassel
- Afawi Zaid
- Andrade Danielle M.
- Annesi Grazia
- Arslan Mutluay
- Auce Pauls
- Auce Pauls
- Auvinen Pia
- Avbersek Andreja
- Baalen Andreas
- Bahlo Melanie
- Bahlo Melanie
- Balding David J.
- Balestrini Simona
- Bari\u161i\u107 Nina
- Bast Thomas
- Bauer J\ufcrgen
- Baum Larry
- Baum Larry W.
- Baykan Bet\ufcl
- Bebek Nerses
- Becker Albert J.
- Becker Felicitas
- Becker Felicitas
- Bellows Susannah T.
- Bennett Caitlin A.
- Berghuis Bianca
- Berkovic Samuel F.
- Berkovic Samuel F.
- Bianchini Claudia
- Bisulli Francesca
- Blatt Ilan
- Borggr\ue4fe Ingo
- Boysen Katja E.
- Braatz Vera
- Bradfield Jonathan P.
- Braun Kees P.J.
- Brockmann Knut
- Brody Lawrence C.
- Buono Russell J.
- Buono Russell J.
- Burgess Rosemary
- Caglayan S. Hande
- Campbell Ellen
- Canafoglia Laura
- Canavati Christina
- Carpay Johannes A.
- Cascino Gregory D.
- Castellotti Barbara
- Catarino Claudia B.
- Cavalleri Gianpiero L.
- Cavalleri Gianpiero L.
- Cerrato Felecia
- Cherny Stacey S.
- Cherny Stacey S.
- Chinthapalli Krishna
- Chung Seo\u2010Kyung
- Churchhouse Claire
- Coffey Alison J.
- Compston Alastair
- Coppola Antonietta
- Cossette Patrick
- Cossette Patrick
- Cotsapas Chris
- Craig John J.
- Daly Mark J.
- De Jonghe Peter
- De Jonghe Peter
- Delanty Norman
- Delanty Norman
- Dennig Dieter
- Depondt Chantal
- Depondt Chantal
- Devinsky Orrin
- Dixon\u2010Salazar Tracy
- Dlugos Dennis J.
- Dlugos Dennis J.
- Doccini Viola
- Doherty Colin P.
- Doherty Colin P.
- El\u2010Naggar Hany
- Elger Christian E.
- Elger Christian E.
- Ellis Colin A.
- Eriksson Johan G.
- Feng Yen\u2010Chen Anne
- Ferraro Thomas N.
- Ferraro Thomas N.
- Feucht Martha
- Franceschetti Silvana
- Francis Ben
- Franke Andre
- French Jacqueline A.
- French Jacqueline A.
- Freyer Catharine
- Freytag Saskia
- Gabriel Stacey B.
- Gagliardi Monica
- Gallati Sabina
- Gambardella Antonio
- Gaus Verena
- Geller Eric B.
- Gieger Christian
- Glauser Tracy
- Glynn Simon
- Goldstein David B.
- Goldstein David B.
- Granata Tiziana
- Guerrini Renzo
- Gui Hongsheng
- Gundogdu\u2010Eken Asl\u131
- Guo Youling
- Gupta Namrata
- H\ue4usler Martin
- Haan Gerrit\u2010Jan
- Haas Kevin F.
- Hakonarson Hakon
- Hakonarson Hakon
- Hallmann Kerstin
- Haryanyan Garen
- Haut Sheryl
- Hegde Manu
- Heinzen Erin L.
- Heinzen Erin L.
- Helbig Ingo
- Helbig Ingo
- Helbig Katherine L.
- Hengsbach Christian
- Hengsbach Christian
- Hjalgrim Helle
- Howrigan Daniel P.
- Iacomino Michele
- Iacomino Michele
- Ingason Andr\ue9s
- Inoue Yushi
- Jamnadas\u2010Khoda Jennifer
- Jansen Floor E.
- Johns Esther M.C.
- Johnson Michael R.
- Johnson Michael R.
- K\ue4lvi\ue4inen Reetta
- K\ue4lvi\ue4inen Reetta
- Kamalakaran Sitharthan
- Kanaan Moien
- Kantanen Anne\u2010Mari
- Kara Bulent
- Kasperavi\u10di\u16bte Dalia
- Kasteleijn\u2010Nolst Trenite Dorothee
- Kesim Ye\u15fim
- Khankhanian Pouya
- King Chontelle
- Kirsch Heidi E.
- Klein Karl Martin
- Kluger Gerhard
- Knake Susanne
- Knowlton Robert C.
- Koeleman Bobby P.C.
- Korczyn Amos D.
- Korinthenberg Rudolf
- Kousiappa Ioanna
- Kovel Carolien G.F.
- Krause Roland
- Krause Roland
- Krenn Martin
- Krestel Heinz
- Krey Ilona
- Kunz Wolfram S.
- Kunz Wolfram S.
- Kurlemann Gerhard
- Kuzniecky Ruben
- Kuzniecky Ruben I.
- Kwan Patrick
- Kwan Patrick
- La\u161\u161uthov\ue1 Petra
- Labate Angelo
- Lal Dennis
- Lal Dennis
- Lander Eric S.
- Lau Yu\u2010Lung
- Lehesjoki Anna\u2010Elina
- Lehesjoki Anna\u2010Elina
- Lemke Johannes R.
- Lerche Holger
- Lerche Holger
- Leu Costin
- Licchetta Laura
- Lieb Wolfgang
- Lin Bochao D.
- Lindhout Dick
- Linnankivi Tarja
- Lo Warren
- Lo Warren D.
- Lopes\u2010Cendes Iscia
- Lowenstein Daniel H.
- Lowenstein Daniel H.
- Lui Colin H.T.
- Luykx Jurjen J.
- M\uf8ller Rikke S.
- M\ufcller\u2010Schl\ufcter Karen
- Macdonald Alexandra
- Madeleyn Rene
- Madia Francesca
- Maisch Ana F.
- Malovini Alberto
- Mameniskiene Ruta
- Mancardi Maria Margherita
- Manna Lorella
- Marini Carla
- Marson Anthony G.
- Marson Anthony G.
- May Patrick
- Mayer Thomas
- Mayer Thomas
- McCormack Mark
- McCormack Mark
- McKenna Kevin
- Mei Davide
- Mills James L.
- Minardi Raffaella
- Mirza Nasir
- Mo Kelly
- Moerzinger Martina
- Molloy Anne M.
- Montomoli Martino
- Mountier Emily
- Muhle Hiltrud
- Muhle Hiltrud
- N\uf6then Markus M.
- N\ufcrnberg Peter
- Neale Benjamin M.
- Newton Mark
- Ng Ping\u2010Wing
- O'Brien Terence J.
- O\u2019Brien Terence J.
- Oliver Karen L.
- Palotie Aarno
- Pangilinan Faith
- Papacostas Savvas S.
- Parrini Elena
- Pendziwiat Manuela
- Peter Sarah
- Petrovski Slav\ue9
- Petrovski Slav\ue9
- Pickrell William O.
- Pippucci Tommaso
- Poduri Annapurna
- Poduri Annapurna
- Powell Robert
- Privitera Michael
- Privitera Michael
- Rademacher Annika
- Rademacher Michael
- Rademaker Koen
- Radtke Rodney
- Rau Sarah
- Rau Sarah
- Rees Mark I.
- Regan Brigid M.
- Reif Philipp S.
- Reif Philipp S.
- Reinthaler Eva M.
- Rodrigues Baldez Roiza A.
- Rosenow Felix
- Rosenow Felix
- Saarela Anni
- Sadleir Lynette G.
- Sadoway Tara R.
- Salman Bar\u131\u15f
- Salpietro Vincenzo
- Sander Josemir W.
- Sander Thomas
- Scattergood Theresa
- Schachter Steven
- Schachter Steven C.
- Schankin Christoph J.
- Schankin Christoph J.
- Scheffer Ingrid E.
- Scheffer Ingrid E.
- Schijven Dick
- Schmitz Bettina
- Schneider Natascha
- Schoch Susanne
- Schreiber Herbert
- Schubert\u2010Bast Susanne
- Schulze\u2010Bonhage Andreas
- Sedl\ue1\u10dkov\ue1 Lucie
- Sham Pak C.
- Sham Pak C.
- Shih Jerry J.
- Shilling Hannah
- Shukralla Arif
- Sills Graeme J.
- Sills Graeme J.
- Sisodiya Sanjay M.
- Sisodiya Sanjay M.
- Slattery Lisa
- Smit Dirk J.A.
- Smith Alexander W.
- Smith David F.
- Smith Michael C.
- Smith Philip E.
- Sonsma Anja C.M.
- Speed Doug
- Sperling Michael R.
- Sperling Michael R.
- Spiczak Sarah
- Spiczak Sarah
- Stamberger Hannah
- Steinhoff Bernhard J.
- Steinhoff Bernhard J.
- Stella Vari Maria
- Stephani Ulrich
- Stephani Ulrich
- Stevelink Remi
- Stewart Randy
- Stipa Carlotta
- Strauch Konstantin
- Striano Pasquale
- Striano Pasquale
- Stroink Hans
- Surges Rainer
- Suzuki Toshimitsu
- Tan K. Meng
- Tanteles George A.
- Tashman Katherine
- Thio Liu Lin
- Thomas G. Neil
- Tinuper Paolo
- Todaro Marian
- Todaro Marian
- Topaloglu P\u131nar
- Tozzi Rossana
- Tumiene Birute
- Turkdogan Dilsad
- U\u11fur\u2010\u130\u15feri Sibel
- Vari Maria S.
- Vetro Annalisa
- Vining Eileen P. G.
- Visscher Frank
- Vl\u10dkov\ue1 Mark\ue9ta
- Walley Nicole M.
- Weber Yvonne G.
- Weber Yvonne G.
- Weckhuysen Dorien
- Weckhuysen Sarah
- Wei Zhi
- Weisenberg Judith
- Whelan Christopher D.
- Widdess\u2010Walsh Peter
- Wolff Markus
- Wolking Stefan
- Wolking Stefan
- Y\ufccesan Emrah
- Yamakawa Kazuhiro
- Yang Wanling
- Yap\u131c\u131 Zuhal
- Yis Uluc
- Zagaglia Sara
- Zara Federico
- Zara Federico
- Zimprich Fritz
- Zsurka G\ue1bor
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Distinct gene-set burden patterns underlie common generalized and focal epilepsies
- Author
- 6zkara \uc7i\u11fdem
- \u160t\u11brbov\ue1 Katalin
- Abbott Liam E
- Achtyes Eric D
- Afawi Zaid
- Andrade Danielle M
- Annesi Grazia
- Arslan Mutluay
- Auce Pauls
- Auvinen Pia
- Azevedo Maria Helena
- Bahlo Melanie
- Balestrini Simona
- Bari\u161i\u107 Nina
- Bass Nick
- Bauer J\ufcrgen
- Baum Larry W
- Baykan Bet\ufcl
- Bebek Nerses
- Becker Felicitas
- Bellows Susannah T
- Bennett Caitlin A
- Berkovic Samuel F
- Bianchini Claudia
- Bisulli Francesca
- Blackwood Douglas
- Blatt Ilan
- Bobbili Dheeraj Reddy
- Borggr\ue4fe Ingo
- Braatz Vera
- Brockmann Knut
- Bromet Evelyn J
- Buckley Peter F
- Buono Russell J
- Burgess Rosemary
- Byrnes Andrea
- Caglayan Hande S
- Canafoglia Laura
- Canavati Christina
- Carvalho Celia Barreto
- Castellotti Barbara
- Cavalleri Gianpiero L
- Cerrato Felecia
- Cherny Stacey S
- Chung Seo-Kyung
- Churchhouse Claire
- Ciullo Valentina
- Cohort Genomic Psychiatry
- Cossette Patrick
- Cotsapas Chris
- Daly Mark J
- DeJonghe Peter
- Delanty Norman
- Dennig Dieter
- Depondt Chantal
- Devinsky Orrin
- Dhindsa Ryan S
- Dixon-Salazar Tracy
- Dlugos Dennis J
- Doccini Viola
- Doherty Colin P
- El-Naggar Hany
- Elger Christian E
- Ellis Colin A
- Fanous Ayman H
- Feng Yen-Chen Anne
- Ferraro Thomas N
- Franceschetti Silvana
- French Jacqueline A
- Freyer Catharine
- Gabriel Stacey B
- Gagliardi Monica
- Gallati Sabina
- Gambardella Antonio
- Gili Tommaso
- Goldstein David B
- Granata Tiziana
- Guerrini Renzo
- Gundogdu-Eken Asl\u131
- Gupta Namrata
- H\ue4usler Martin
- Hakonarson Hakon
- Haryanyan Garen
- Hegde Manu
- Heinzen Erin L
- Helbig Ingo
- Helbig Katherine L
- Hengsbach Christian
- Heyne Henrike
- Howrigan Daniel P
- Iacomino Michele
- Inoue Yushi
- Johns Esther M C
- Johnson Michael R
- Johnstone Mandy
- K\ue4lvi\ue4inen Reetta
- Kamalakaran Sitharthan
- Kanaan Moien
- Kara Bulent
- Kesim Ye\u15fim
- Khankhanian Pouya
- King Chontelle
- Klein Karl Martin
- Kluger Gerhard
- Knake Susanne
- Knowles James A
- Koko Mahmoud
- Korczyn Amos D
- Korinthenberg Rudolf
- Kotov Roman
- Kousiappa Ioanna
- Krause Roland
- Krause Roland
- Krestel Heinz
- Krey Ilona
- Kunz Wolfram S
- Kurlemann Gerhard
- Kurlemann Gerhard
- Kuzniecky Ruben I
- Kwan Patrick
- La\u161\u161uthov\ue1 Petra
- Labate Angelo
- Lal Dennis
- Lander Eric S
- Lehesjoki Anna-Elina
- Lehrer Douglas S
- Lemke Johannes R
- Lerche Holger
- Lerche Holger
- Leu Costin
- Licchetta Laura
- Linnankivi Tarja
- Lo Warren
- Lowenstein Daniel H
- Lui Colin H T
- M\ufcller-Schl\ufcter Karen
- Macciardi Fabio
- Macdonald Alexandra
- Madeleyn Rene
- Madia Francesca
- Maisch Ana F
- Malaspina Dolores
- Mancardi Maria Margherita
- Manna Lorella
- Marder Stephen R
- Marini Carla
- Marson Anthony G
- May Patrick
- May Patrick
- Mayer Thomas
- McCarroll Steven A
- McCormack Mark
- McIntosh Andrew
- McKenna Kevin
- McQuillin Andrew
- Medeiros Helena
- Mei Davide
- Minardi Raffaella
- Mo Kelly
- Montomoli Martino
- Morley Christopher P
- Mountier Emily
- Muhle Hiltrud
- Neale Benjamin M
- Nothnagel Michael
- O'Brien Terence J
- Palotie Aarno
- Papacostas Savvas S
- Parrini Elena
- Pato Carlos N
- Pato Michele T
- Pendziwiat Manuela
- Perkins Diana O
- Petrovski Slav\ue9
- Pickrell William O
- Pippucci Tommaso
- Piras Fabrizio
- Piras Federica
- Poduri Annapurna
- Powell Robert
- Privitera Michael
- Rademacher Annika
- Rademacher Michael
- Rapaport
- Rau Sarah
- Rees Mark I
- Regan Brigid M
- Reif Andreas
- Reif Philipp S
- Rosenow Felix
- Saarela Anni
- Sadleir Lynette G
- Sadoway Tara R
- Salman Bar\u131\u15f
- Salpietro Vincenzo
- Sander Thomas
- Schachter Steven
- Schankin Christoph J
- Scheffer Ingrid E
- Schneider Natascha
- Schreiber Herbert
- Schubert-Bast Susanne
- Schulze-Bonhage Andreas
- Sedl\ue1\u10dkov\ue1 Lucie
- Shain Catherine
- Sham Pak C
- Shiedley Beth R
- Shilling Hannah
- Shukralla Arif
- Sills Graeme J
- Singh Tarjinder
- Sisodiya Sanjay M
- Sobell Janet L
- Solomonson Matthew
- Spalletta Gianfranco
- Sperling Michael R
- Stamberger Hannah
- Stanley Kate E
- Steinhoff Bernhard J
- Stephani Ulrich
- Stewart Randy
- Stipa Carlotta
- Striano Pasquale
- Suzuki Toshimitsu
- Tanteles George A
- Tashman Katherine
- Tinuper Paolo
- Todaro Marian
- Topaloglu P\u131nar
- Tumiene Birute
- Turkdogan Dilsad
- U\u11fur-\u130\u15feri Sibel
- vanBaalen Andreas
- Vari Maria Stella
- Vetro Annalisa
- Vl\u10dkov\ue1 Mark\ue9ta
- vonSpiczak Sarah
- Watts Nick
- Weber Yvonne G
- Weckhuysen Dorien
- Weckhuysen Sarah
- Wolking Stefan
- Y\ufccesan Emrah
- Yamakawa Kazuhiro
- Yap\u131c\u131 Zuhal
- Yis Uluc
- Zagaglia Sara
- Zara Federico
- Zsurka G\ue1bor
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi Ali
- Amitrano Sara
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson Madeleine
- Anderson Peter
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew Angela
- Andrew B.
- Andrew Gratrix
- Andrews E.
- Andrews Shea J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe David
- Antinori Andrea
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino Maia
- Arabi Y.M.
- Aravindan Latha
- Arbane Gill
- Archer Katie
- Arden T.
- Arias Sonia Sousa
- Arif S.
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- Armstrong Ruth
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- Watson G.
- Watson J.
- Watters M.
- Waugh Victoria
- Weaver Jane
- Webster A.
- Webster D.
- Webster K.
- Wei Shuying
- Weiss S.T.
- Weldon C.H.
- Wells C.
- Welters Ingeborg D.
- Weston H.
- Whileman A.
- Whitbread J.
- White Deborah
- White Ian
- White K.
- White M.
- White N.
- White N.
- Whiteley Simon
- Whiteside J.
- Whittle H.
- Whitton Christopher
- Whyte Clare
- Wicks S.J.
- Wilby Elizabeth
- Wilcox L.
- Wilcox R.
- Wild H.
- Wild Laura
- Wiles M.
- Wilkins J.
- Wilkinson Ami
- Wilkinson B.
- Willer C.
- Williams A.
- Williams A.
- Williams A.
- Williams Alexander T.
- Williams D.
- Williams E.
- Williams F.
- Williams Gemma
- Williams H.
- Williams Karen
- Williams Marie
- Williams P.
- Williams S.
- Williams Toran
- Willis C.
- Willis Heather
- Wills M.
- Willson J.
- Wilson A.
- Wilson D.J.
- Wilson James F.
- Wilson Jean
- Winnard Sarah
- Winter-Goodwin B.
- Wolf-Roberts R.
- Wolford Brooke N.
- Wong Joanna
- Wood D.
- Wood Hannah-Louise
- Wood Suzanne
- Wood T.
- Woodford C.
- Woodruff M.
- Woods L.
- Woodyatt Wiesia
- Woolley A.E.
- Worner R.
- Worsley L.
- Wray G.
- Wren L.
- Wright D.
- Wright J.
- Wright M.
- Wrobel Nicola
- Wu Yang
- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier Kugan
- Xue X.
- Yadav A.
- Yang Jian
- Yassen Amr M.
- Yates Brian
- Ye C.
- Yun Nikki
- Zainy Tala
- Zak Anne
- Zaki Ahmed
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg Hugo
- Zechner Marie
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng Chenqing
- Zhou W.
- Zitter L.
- Zlatopolsky Menachem
- Zongo Olivier
- Zucchi P.
- Zyndorf Marissa
- Zöllner S.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals
- Author
- 6zkara \uc7i\u11fdem
- \u160t\u11brbov\ue1 Katalin
- Abbott Liam E.
- Abou-Khalil Bassel W.
- Afawi Zaid
- Ali Quratulain Zulfiqar
- Allen Andrew S.
- Amadori Elisa
- Anderson Joe
- Andrade Danielle M.
- Annesi Grazia
- Arslan Mutluay
- Auce Pauls
- Baker Mark D.
- Balestrini Simona
- Barba Carmen
- Bari\u161i\u107 Nina
- Barisic Nina
- Bartolomei Fabrice
- Baum Larry W.
- Baumgartner Tobias H.
- Baykan Bet\ufcl
- Baykan Betul
- Bebek Nerses
- Becker Felicitas
- Bennett Caitlin A.
- Berkovic Samuel F.
- Beydoun Ahmad
- Bianchini Claudia
- Bisulli Francesca
- Blatt Ilan
- Borggr\ue4fe Ingo
- Borggrafe Ingo
- Bosselmann Christian
- Br\ufcnger Tobias
- Braatz Vera
- Brockmann Knut
- Bruenger Tobias
- Buono Russell J.
- Busch Robyn M.
- Byrnes Andrea E.
- Caglayan S. Hande
- Canafoglia Laura
- Canavati Christina
- Castellotti Barbara
- Cavalleri Gianpiero L.
- Cerrato Felecia
- Chassoux Francine
- Cherny Stacey S.
- Chou I-Jun
- Chung Seo-Kyung
- Churchhouse Claire
- Clark Peggy O.
- Cole Andrew J.
- Collins Ryan L.
- Cosico Mahgenn
- Cossette Patrick
- Cotsapas Chris
- Cusick Caroline
- Davis Lea
- De Jonghe Peter
- Delanty Norman
- Dennig Dieter
- Depondt Chantal
- Depondti Chantal
- Derambure Philippe
- Devinsky Orrin
- Dhindsa Ryan S.
- Dixon-Salazar Tracy
- Dlugos Dennis J.
- Dlugos Dennis J.
- Doccini Viola
- Doherty Colin P.
- El-Naggar Hany
- Ellis Colin A.
- Faucon Annika
- Feng Yen-Chen Anne
- Ferguson Lisa
- Ferraro Thomas N.
- Feucht Martha
- Fitch Eryn
- Fonferko-Shadrach Beata
- Franceschetti Silvana
- French Jacqueline A.
- Freyer Catharine
- Gagliardi Monica
- Gambardella Antonio
- Ganesan Shiva
- Giacomini Thea
- Glauser Tracy A.
- Goldberg Ethan
- Goldman Alicia
- Goldstein David B.
- Granata Tiziana
- Greenberg David A.
- Guerrini Renzo
- Gundogdu-Eken Asl\u131
- Gundogdu-Eken Asli
- Gupta Namrata
- H\ue4usler Martin
- Haas Kevin
- Haeusler Martin
- Hakonarson Hakon
- Haryanyan Garen
- Hegde Manu
- Heinzen Erin L.
- Helbig Ingo
- Helbig Ingo
- Helbig Ingo
- Helbig Katherine L.
- Hengsbach Christian
- Heyne Henrike
- Hirose Shinichi
- Hirsch Edouard
- Ho Chen-Jui
- Howrigan Daniel P.
- Hucks Donald
- Iacomino Michele
- Inoue Yushi
- Ishii Atsushi
- Jehi Lara
- Johnson Michael R.
- K\ue4lvi\ue4inen Reetta
- Kalviainen Reetta
- Kamalakaran Sitharthan
- Kanaan Moien
- Kara Bulent
- Kariuki Symon M.
- Kariuki SymonM.
- Kegele Josua
- Kesim Ye\u15fim
- Kesim Yesim
- Khoueiry-Zgheib Nathalie
- Khoury Jean
- King Chontelle
- Klein Karl Martin
- Kluger Gerhard
- Knake Susanne
- Korczyn Amos D.
- Korinthenberg Rudolf
- Kousiappa Ioanna
- Krause Roland
- Krestel Heinz
- Krey Ilona
- Kunz Wolfram S.
- Kurlemann Gerhard
- Kurlemann Gerhard
- Kuzniecky Ruben I.
- Kwan Patrick
- Kwan Patrick
- La\u161\u161uthov\ue1 Petra
- Labate Angelo
- Lal Dennis
- Lal Dennis
- Lal Dennis
- Lassuthova Petra
- Lauxmann Stephan
- Lawthom Charlotte
- Leech Stephanie L.
- Lehesjoki Anna-Elina
- Lemke Johannes R.
- Lerche Holger
- Lesca Gaetan
- Leu Costin
- Leu Costin
- Lewis-Smith David
- Lewis-Smith David
- Licchetta Laura
- Lin Chih-Hsiang
- Lin Kuang-Lin
- Linnankivi Tarja
- Lino Nobili
- Lo Warren
- Lowenstein Daniel H.
- Lui Colin H. T.
- M\ufcller-Schl\ufcter Karen
- Macnee Marie
- Madeleyn Rene
- Madia Francesca
- Maillard Louis
- Mancardi Maria Margherita
- Manna Lorella
- Marson Anthony G.
- May Patrick
- Mayer Thomas
- McGraw Christopher M.
- McGraw ChristopherM.
- McKenna Kevin
- Mei Davide
- Michel V\ue9ronique
- Michel Veronique
- Minardi Raffaella
- Montanucci Ludovica
- Montomoli Martino
- Mostacci Barbara
- Motelow Joshua E.
- Muccioli Lorenzo
- Mueller-Schlueter Karen
- Muhle Hiltrud
- Najm Imad M.
- Nasreddine Wassim
- Neale Benjamin M.
- Neubauer Bernd A.
- Newton Charles R. J. C.
- Niestroj Lisa-Marie
- Noebels Jeffrey L.
- O'Brien Terence J.
- O\u2019Brien Terence J.
- Owusu-Agyei Seth
- Ozkara Cigdem
- Papacostas Savvas S.
- Parrini Elena
- Parthasarathy Shridhar
- Pendziwiat Manuela
- Petrovski Slav\ue9
- Petrovski Slave
- Pickrell William O.
- Pippucci Tommaso
- Poduri Annapurna
- Povysil Gundula
- Powell Robert H. W.
- Privitera Michael
- Rademacher Annika
- Ragona Francesca
- Rau Sarah
- Rees Mark I.
- Regan Brigid M.
- Reif Philipp S.
- Reinthaler Eva
- Rheims Sylvain
- Riva Antonella
- Rosenow Felix
- Ryvlin Philippe
- Saarela Anni
- Sadleir Lynette G.
- Sadoway Tara R.
- Salman Bar\u131\u15f
- Salman Baris
- Salpietro Vincenzo
- Scala Marcello
- Schachter Steven
- Schaller Andr\ue9
- Schaller Andre
- Schankin Christoph J.
- Scheffer Ingrid E.
- Schneider Natascha
- Schreiber Herbert
- Schubert-Bast Susanne
- Schulze-Bonhage Andreas
- Sedl\ue1\u10dkov\ue1 Lucie
- Sedlackova Lucie
- Shain Catherine
- Sham Pak C.
- Sham Pakc.
- Shiedley Beth R.
- Shukralla Arif
- Siena S. Anthony
- Sills Graeme J.
- Singh Tarjinder
- Sisodiya Sanjay M.
- Solomonson Matthew
- Sperling Michael R.
- Stamberger Hannah
- Stanley Kate E.
- Steinhoff Bernhard J.
- Stephani Ulrich
- Sterbova Katalin
- Stewart Randy
- Striano Pasquale
- Surges Rainer
- Suzuki Toshimitsu
- Talkowski Michael
- Taneja Randip S.
- Tanteles George A.
- Tashman Katherine
- Thomas Rhys H.
- Timonen Oskari
- Tinuper Paolo
- Todaro Marian
- Topaloglu P\u131nar
- Topaloglu Pinar
- Tsai Meng-Han
- Tumiene Birute
- Turkdogan Dilsad
- U\u11fur-\u130\u15feri Sibel
- Ugur-Iseri Sibel
- Utkus Algirdas
- Vaidiswaran Priya
- Valton Luc
- van Baalen Andreas
- Vari Maria Stella
- Vetro Annalisa
- Vl\u10dkov\ue1 Mark\ue9ta
- Vlckova Marketa
- von Spiczak Sarah
- von Wrede Randi
- Wagner Ryan G.
- Watts Nick
- Weber Yvonne G.
- Weckhuysen Sarah
- Widdess-Walsh Peter
- Wolff Markus
- Wolking Stefan
- Wu David
- Xian Julie
- Y\ufccesan Emrah
- Yamakawa Kazuhiro
- Yap\u131c\u131 Zuhal
- Yapici Zuhal
- Yiolanda Christou
- Yis Uluc
- Yucesan Emrah
- Zagaglia Sara
- Zara Federico
- Zimprich Friedrich
- Zsurka G\ue1bor
- Zsurka Gabor
- Publication venue
- Publication date
- 01/01/2023
- Field of study