Additional file 4: Figure S2. of Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s disease

Upregulated genes in AD (Br5–6). Molecular networks are presented which were generated by the core analysis of the Ingenuity knowledge database (see also Methods section and www.ingenuity.com for explanation and details). The symbols (with Genbank Gene name) in the network come from: input genes (Additional file 6: Table S3: upregulated genes in AD Br5–6) see also description below (Additional file 5: Figure S3). (PDF 17491 kb

Additional file 3: Table S2. of Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s disease

Contains compilations of lists of (disease) genes previously implicated in relevant disease. The entries are used to label the molecular network in Additional file 4: Figure S2 and Additional file 5: Figure S3. (XLS 190 kb

Boletín de Segovia: Número 68 - 1871 junio 7

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

Additional file 7: Figure S4. of Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s disease

In this file a standard output of the most established and most simple (linear) representation of biology (canonical pathways) are given on the basis of input data (in this case statistically significant BH corrected upregulated genes in AD; Additional file 6: Table S3). The knowledge database recognizes enriched biological themes (for example: unfolded protein response etc.) in the input data compared to a random distribution of genes over all relevant biological themes. In the figure, the y-axis denotes statistical significance levels, the horizontal axis contains biological themes. The bars indicate the statistical significance for that particular theme. The orange horizontal line gives the significance level P = 0.05. The orange irregular line follows the ratio (number of molecules in particular theme/relevant number of genes under consideration). For further details, see www.ingenuity.com . (JPEG 76 kb

Additional file 9: Figure S5. of Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer’s disease

See description for Additional file 7: Figure S4, but now the input used are the down-regulated genes in CPE AD (5–6) Additional file 8: Table S4). (JPEG 56 kb