In this file a standard output of the most established and most simple (linear) representation of biology (canonical pathways) are given on the basis of input data (in this case statistically significant BH corrected upregulated genes in AD; Additional file 6: Table S3). The knowledge database recognizes enriched biological themes (for example: unfolded protein response etc.) in the input data compared to a random distribution of genes over all relevant biological themes. In the figure, the y-axis denotes statistical significance levels, the horizontal axis contains biological themes. The bars indicate the statistical significance for that particular theme. The orange horizontal line gives the significance level P = 0.05. The orange irregular line follows the ratio (number of molecules in particular theme/relevant number of genes under consideration). For further details, see www.ingenuity.com . (JPEG 76 kb
