637 research outputs found
Optimized quantum nondemolition measurement of a field quadrature
We suggest an interferometric scheme assisted by squeezing and linear
feedback to realize the whole class of field-quadrature quantum nondemolition
measurements, from Von Neumann projective measurement to fully non-destructive
non-informative one. In our setup, the signal under investigation is mixed with
a squeezed probe in an interferometer and, at the output, one of the two modes
is revealed through homodyne detection. The second beam is then
amplitude-modulated according to the outcome of the measurement, and finally
squeezed according to the transmittivity of the interferometer. Using strongly
squeezed or anti-squeezed probes respectively, one achieves either a projective
measurement, i.e. homodyne statistics arbitrarily close to the intrinsic
quadrature distribution of the signal, and conditional outputs approaching the
corresponding eigenstates, or fully non-destructive one, characterized by an
almost uniform homodyne statistics, and by an output state arbitrarily close to
the input signal. By varying the squeezing between these two extremes, or
simply by tuning the internal phase-shift of the interferometer, the whole set
of intermediate cases can also be obtained. In particular, an optimal quantum
nondemolition measurement of quadrature can be achieved, which minimizes the
information gain versus state disturbance trade-off
Measurements of Ice Shelf Water beneath the front of the Ross Ice Shelf using gliders
Measurements made by an underwater glider deployed near the Ross Ice Shelf were used to identify the presence of Ice Shelf Water (ISW), which is defined as seawater with its potential temperature lower than its surface freezing point temperature. Properties logged by the glider included in situ temperature, electrical conductivity, pressure, GPS location at surfacings and time. For most of the first 30 recorded dives of its deployment, evidence suggests the glider was prevented from surfacing due to being under the ice shelf. For dives under the ice shelf, farthest from the ice shelf front, ISW layers of varying thicknesses and depth locations were observed; between 2 m thick (centred at 231 m depth) to >93 m thick (centred at >360 m). For dives under the ice shelf, close to the ice shelf front, either no ISW was observed or ISW layers were centred at shallower depths (116–127 m). Thicker ISW layers (e.g. up to 250 m thickness centred at 421 m) were observed for some glider dives in open water in front of the Ross Ice Shelf. No in situ supercooling (water colder than the pressure-dependent freezing point temperature) was observed
Feedback-control of quantum systems using continuous state-estimation
We present a formulation of feedback in quantum systems in which the best
estimates of the dynamical variables are obtained continuously from the
measurement record, and fed back to control the system. We apply this method to
the problem of cooling and confining a single quantum degree of freedom, and
compare it to current schemes in which the measurement signal is fed back
directly in the manner usually considered in existing treatments of quantum
feedback. Direct feedback may be combined with feedback by estimation, and the
resulting combination, performed on a linear system, is closely analogous to
classical LQG control theory with residual feedback.Comment: 12 pages, multicol revtex, revised and extende
Study of High-Spin States and Three-Quasiparticle (p,Ď€) Transitions on Light Targets
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
Kinetic energy driven superconductivity in doped cuprates
Within the t-J model, the mechanism of superconductivity in doped cuprates is
studied based on the partial charge-spin separation fermion-spin theory. It is
shown that dressed holons interact occurring directly through the kinetic
energy by exchanging dressed spinon excitations, leading to a net attractive
force between dressed holons, then the electron Cooper pairs originating from
the dressed holon pairing state are due to the charge-spin recombination, and
their condensation reveals the superconducting ground-state. The electron
superconducting transition temperature is determined by the dressed holon pair
transition temperature, and is proportional to the concentration of doped holes
in the underdoped regime. With the common form of the electron Cooper pair, we
also show that there is a coexistence of the electron Cooper pair and
antiferromagnetic short-range correlation, and hence the antiferromagnetic
short-range fluctuation can persist into the superconducting state. Our results
are qualitatively consistent with experiments.Comment: 6 pages, Revtex, two figures are included, corrected typo
4pi Models of CMEs and ICMEs
Coronal mass ejections (CMEs), which dynamically connect the solar surface to
the far reaches of interplanetary space, represent a major anifestation of
solar activity. They are not only of principal interest but also play a pivotal
role in the context of space weather predictions. The steady improvement of
both numerical methods and computational resources during recent years has
allowed for the creation of increasingly realistic models of interplanetary
CMEs (ICMEs), which can now be compared to high-quality observational data from
various space-bound missions. This review discusses existing models of CMEs,
characterizing them by scientific aim and scope, CME initiation method, and
physical effects included, thereby stressing the importance of fully 3-D
('4pi') spatial coverage.Comment: 14 pages plus references. Comments welcome. Accepted for publication
in Solar Physics (SUN-360 topical issue
Kinome-wide analysis of the effect of statins in colorectal cancer
Background Epidemiological studies and meta-analyses show an association between statin use and a reduced incidence of colorectal cancer (CRC). We have shown that statins act on CRC through bone morphogenetic protein (BMP) signalling, but the exact cellular targets and underlying mechanism of statin action remain elusive. In this study, we set out to assess the influence of statins on global cancer cell signalling by performing an array-based kinase assay using immobilised kinase substrates spanning the entire human kinome. Methods CRC cells with or without Lovastatin treatment were used for kinome analysis. Findings on kinome arrays were further confirmed by immunoblotting with activity-specific antibodies. Experiments in different CRC cell lines using immunoblotting, siRNA-mediated knockdown and treatment with specific BMP inhibitor Noggin were performed. The relevance of in vitro findings was confirmed in xenografts and in CRC patients treated with Simvastatin. Results Kinome analysis can distinguish between non-specific, toxic effects caused by 10 mu M of Lovastatin and specific effects on cell signalling caused by 2 mu M Lovastatin. Statins induce upregulation of PTEN activity leading to downregulation of the PI3K/Akt/mTOR signalling. Treatment of cells with the specific BMP inhibitor Noggin as well as PTEN knockdown and transfection of cells with a constitutively active form of AKT abolishes the effect of Lovastatin on mTOR phosphorylation. Experiments in xenografts and in patients treated with Simvastatin confirm statin-mediated BMP pathway activation, activation of PTEN and downregulation of mTOR signalling. Conclusions Statins induce BMP-specific activation of PTEN and inhibition of PI3K/Akt/mTOR signalling in CRC.Cellular mechanisms in basic and clinical gastroenterology and hepatolog
Kinome-wide analysis of the effect of statins in colorectal cancer (Mar, 10.1038/s41416-021-01318-9, 2021)
Cellular mechanisms in basic and clinical gastroenterology and hepatolog
Exact Hypersurface-Homogeneous Solutions in Cosmology and Astrophysics
A framework is introduced which explains the existence and similarities of
most exact solutions of the Einstein equations with a wide range of sources for
the class of hypersurface-homogeneous spacetimes which admit a Hamiltonian
formulation. This class includes the spatially homogeneous cosmological models
and the astrophysically interesting static spherically symmetric models as well
as the stationary cylindrically symmetric models. The framework involves
methods for finding and exploiting hidden symmetries and invariant submanifolds
of the Hamiltonian formulation of the field equations. It unifies, simplifies
and extends most known work on hypersurface-homogeneous exact solutions. It is
shown that the same framework is also relevant to gravitational theories with a
similar structure, like Brans-Dicke or higher-dimensional theories.Comment: 41 pages, REVTEX/LaTeX 2.09 file (don't use LaTeX2e !!!) Accepted for
publication in Phys. Rev.
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