642 research outputs found
Genetic Determinants of Skin Color, Aging, and Cancer
Chapter 1 gives a general introduction to this thesis.
In Chapter 2 we validated perceived skin color as skin color measurement.
In Chapter 3 we investigated whether digitally quantified skin color was a suitable measure to discover new skin color genes.
In Chapter 4 we investigated the genetic basis of skin color by a genome-wide association study followed by a replication analysis in 17,262 individuals of European ancestry from the Netherlands, UK and Australia.
In Chapter 5 we validated a new digital image analysis technique to measure severity
of different skin aging features including wrinkling, pigmented spots and telangiectasia.
In Chapter 6 we have used the digitally quantified pigmented spots measures to search for associated genetic variants.
In Chapter 7 we studied intrinsic and extrinsic risk factors for the skin aging feature sagging eyelids.
In Chapter 8 we investigated genetic susceptibility to the pre-malignant actinic keratosis.
In Chapter 9 we have summarized the pattern of genetic association between 13 genes and pigmentation traits, pigmented spots, and cutaneous malignancies.
In Chapter 10 we discuss the results of all studies in this thesis
Study of High-Spin States and Three-Quasiparticle (p,π) Transitions on Light Targets
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
Kinematically Complete Measurements of p+p → p+n+(pi+) Near Threshold
This research was sponsored by the National Science Foundation Grant NSF PHY-931478
Progress on the Experimental Search for Charge Symmetry Breaking (CSB) in n-p Scattering
This work was supported by the National Science Foundation Grant NSF PHY 81-14339 and by Indiana Universit
An Experimental Test of Charge Symmetry in n-p Scattering
This work was supported by the National Science Foundation Grants NSF PHY 78-22774 A03, NSF PHY 81-14339, and by Indiana Universit
Application of Pulsed Field Gel Electrophoresis to Determine γ-ray-induced Double-strand Breaks in Yeast Chromosomal Molecules
The frequency of DNA double-strand breaks (dsb) was determined in yeast cells exposed to γ-rays under anoxic conditions. Genomic DNA of treated cells was separated by pulsed field gel electrophoresis, and two different approaches for the evaluation of the gels were employed: (1) The DNA mass distribution profile obtained by electrophoresis was compared to computed profiles, and the number of DSB per unit length was then derived in terms of a fitting procedure; (2) hybridization of selected chromosomes was performed, and a comparison of the hybridization signals in treated and untreated samples was then used to derive the frequency of dsb
K Meson Production in the Proton-Proton Reaction at 3.67 GeV/c
The total cross section of the reaction has been determined
for proton--proton reactions with . This represents the
first cross section measurement of the channel near
threshold, and is equivalent to the inclusive cross section at
this beam momentum. The cross section determined at this beam momentum is about
a factor 20 lower than that for inclusive meson production at
the same CM energy above the corresponding threshold. This large difference in
the and meson inclusive production cross sections in proton-proton
reactions is in strong contrast to cross sections measured in sub-threshold
heavy ion collisions, which are similar in magnitude at the same energy per
nucleon below the respective thresholds.Comment: 12 pages, 3 figures Phys. Lett. B in prin
Production of Mesons in the Reaction at 3.67 GeV/c
The ratio of the total exclusive production cross sections for
and mesons has been measured in the reaction at
GeV/c. The observed ratio is
from which the exclusive
meson production cross section is determined to be
. Differential cross section
distributions have been measured. Their shape is consistent with isotropic
meson production.Comment: 14 pages, 5 figures, accepted by Phys.Lett.
The Planetary Nebula Luminosity Function at the Dawn of Gaia
The [O III] 5007 Planetary Nebula Luminosity Function (PNLF) is an excellent
extragalactic standard candle. In theory, the PNLF method should not work at
all, since the luminosities of the brightest planetary nebulae (PNe) should be
highly sensitive to the age of their host stellar population. Yet the method
appears robust, as it consistently produces < 10% distances to galaxies of all
Hubble types, from the earliest ellipticals to the latest-type spirals and
irregulars. It is therefore uniquely suited for cross-checking the results of
other techniques and finding small offsets between the Population I and
Population II distance ladders. We review the calibration of the method and
show that the zero points provided by Cepheids and the Tip of the Red Giant
Branch are in excellent agreement. We then compare the results of the PNLF with
those from Surface Brightness Fluctuation measurements, and show that, although
both techniques agree in a relative sense, the latter method yields distances
that are ~15% larger than those from the PNLF. We trace this discrepancy back
to the calibration galaxies and argue that, due to a small systematic error
associated with internal reddening, the true distance scale likely falls
between the extremes of the two methods. We also demonstrate how PNLF
measurements in the early-type galaxies that have hosted Type Ia supernovae can
help calibrate the SN Ia maximum magnitude-rate of decline relation. Finally,
we discuss how the results from space missions such as Kepler and Gaia can help
our understanding of the PNLF phenomenon and improve our knowledge of the
physics of local planetary nebulae.Comment: 12 pages, invited review at the conference "The Fundamental Cosmic
Distance Scale: State of the Art and Gaia Perspective", to appear in
Astrophysics and Space Scienc
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