History of the town of Candia, Rockingham County, N.H. : from its first settlement to the present time.

Folded map inserted between p. 478 and 479.; Back of first plate inscribed: [F.E.?] Robie[\u27s] book, presented to him by his brother Edd

THE USE OF REACTIVE STRENGTH INDEX-MODIFIED AS AN EXPLOSIVE PERFORMANCE MEASUREMENT IN MALE AND FEMALE ATHLETES

This study examined the reliability of reactive strength index-modified (RSImod), relationships between RSImod and force-time variables, and difference in RSImod between male and female collegiate athletes. 106 Division I collegiate athletes performed unloaded and loaded countermovement jumps. Intraclass correlation coefficients and coefficients of variation were used to establish the reliability of RSImod. Correlations were calculated between RSImod and rate of force development, peak force, and peak power. RSImod appears to be a reliable performance measurement in male and female athletes. Furthermore, RSImod has moderate to very large relationships with rate of force development, peak force, and peak power. Statistically significant differences in RSImod existed between males and females during both unloaded and loaded CMJs

A COMPARISON OF BASEBALL POSITIONAL DIFFERENCES WITH REACTIVE STRENGTH INDEX-MODIFIED

The purpose of this study was to examine positional differences amongst 29 baseball players using the Reactive Strength Index-modified (RSImod) values during unloaded and loaded countermovement jumps (CMJ). A secondary purpose was to determine the relationship between other jump performance characteristics and RSImod values. All athletes underwent CMJ testing and RSImod values were compared between pitchers and position players. The loaded condition CMJ produced statistically different RSImod values between the two groups. Scaled peak force was somewhat more strongly related to RSImod than rate of force development (RFD). The current study indicates that position players may possess higher reactive strength capabilities than pitchers and scaled peak force may be more important than RFD in determining reactive strength characteristics

THE RELATIONSHIP OF THE REACTIVE STRENGTH INDEX-MODIFIED AND MEASURES OF FORCE DEVELOPMENT IN THE ISOMETRIC MID-THIGH PULL

Reactive strength index-modified (RSImod) may be an important variable to measure in the performance testing and monitoring of athletes, and very little work has examined this particular variable. One hundred six Division-I collegiate athletes performed countermovement jumps and the isometric mid-thigh pull. The relationship between the RSImod and variables from the isometric mid-thigh pull representative of explosive performance were evaluated with Pearson’s r. Relationships between RSImod and variables related to explosiveness ranged from moderate to large. Maximum and relative maximum strength had the strongest correlations to RSImod. RSImod appears to be a measure of explosiveness. Furthermore, an athlete’s isometric strength may be an indicator of their reactive strength

REACTIVE STRENGTH INDEX-MODIFIED: A COMPARISON BETWEEN SIX U.S. COLLEGIATE ATHLETIC TEAMS

The purpose of this study was to compare reactive strength index-modified (RSImod) between six U.S. collegiate sport teams. One hundred six athletes performed maximum effort countermovement jumps during unloaded and loaded conditions. RSImod measures for each team were compared using one-way ANOVAs, and Bonferroni post hoc tests where warranted. Statistically significant differences in RSImod values existed between teams during both unloaded (< 1kg) and loaded (20kg) conditions. The greatest RSImod values during both conditions were produced by men’s soccer and followed in order by baseball, women’s volleyball, men’s tennis, women’s soccer, and women’s tennis. The data indicate that athletes from different sports possess different reactive strength characteristics

Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-Ras

Heterogeneity in tumor immune responses is a poorly understood yet critical parameter for successful immunotherapy. In two doxycycline-inducible models where oncogenic H-RasG12V is targeted either to the epidermal basal/stem cell layer with a Keratin14-rtTA transgene (K14Ras), or committed progenitor/suprabasal cells with an Involucrin-tTA transgene (InvRas), we observed strikingly distinct tumor immune responses. On threshold doxycycline levels yielding similar Ras expression, tumor latency, and numbers, tumors from K14Ras mice had an immunosuppressed microenvironment, whereas InvRas tumors had a proinflammatory microenvironment. On a Rag1-/- background, InvRas mice developed fewer and smaller tumors that regressed over time, whereas K14Ras mice developed more tumors with shorter latency than Rag1+/+ controls. Adoptive transfer and depletion studies revealed that B-cell and CD4 T-cell cooperation was critical for tumor yield, lymphocyte polarization, and tumor immune phenotype in Rag1+/+ mice of both models. Coculture of tumor-conditioned B cells with CD4 T cells implicated direct contact for Th1 and regulatory T cell (Treg) polarization, and CD40-CD40L for Th1, Th2, and Treg generation, a response not observed from splenic B cells. Anti-CD40L caused regression of InvRas tumors but enhanced growth in K14Ras, whereas a CD40 agonist mAb had opposite effects in each tumor model. These data show that position of tumor-initiating cells within a stratified squamous epithelial tissue provokes distinct B- and CD4 T-cell interactions, which establish unique tumor microenvironments that regulate tumor development and response to immunotherap

Competition of Mesoscales and Crossover to Tricriticality in Polymer Solutions

We show that the approach to asymptotic fluctuation-induced critical behavior in polymer solutions is governed by a competition between a correlation length diverging at the critical point and an additional mesoscopic length-scale, the radius of gyration. Accurate light-scattering experiments on polystyrene solutions in cyclohexane with polymer molecular weights ranging from 200,000 up to 11.4 million clearly demonstrate a crossover between two universal regimes: a regime with Ising asymptotic critical behavior, where the correlation length prevails, and a regime with tricritical theta-point behavior determined by a mesoscopic polymer-chain length.Comment: 4 pages in RevTeX with 4 figure

A Proposal for A Lean, Fast Mars Round-Trip Mission Architecture: Using Current Technologies for A Human Mission to Mars In The 2030s

We present a lean-minded, fast-transfer mission strategy and architecture concept for a first human mission to Mars that deliberately utilizes a current-technology-favored approach by means of introducing and quantitatively dening two pivotal parameters: 1) an end-to-end Mars mission duration of approximately one year, and 2) a deep space habitat of approximately 4050 metric tons. These parameters are identified and introduced by a 2012 deep space habitat study conducted at the NASA Johnson Space Center (JSC) that focused on a subset of recognized high-engineering-risk factors that may otherwise inhibit or encumber remote space travel to destinations such as Mars or near-Earth asteroids (NEAs). Additional constraints in the study favoring current technology and a lean-minded (very short) surface stay on Mars are shown to offer such Mars mission opportunities in the 2030s, enabled by a combination of on-orbit staging, mission element pre-positioning, and unique round-trip trajectories identied by state-of-the-art astrodynamics algorithms