7 research outputs found

    Beyond "natural-disasters-are-not-natural": the work of state and nature after the 2010 earthquake in Chile

    Get PDF
    Since the 1970s, human ecologists, geographers, Marxian political economists and others have insisted that there is no such thing as a 'natural' disaster. This assertion opened a space not only for exploring socioeconomic conditions that render marginalized populations vulnerable to natural hazards, but also for the formation of a field, the political ecology of hazards. A few political ecologists further interrogated the idea of a natural disaster, asking how different notions of 'the natural' circulate in post-disaster politics and with what effects. This article extends the latter approach by documenting how interconnected categories of 'nature' and 'state' were mutually constituted by narratives of politicians and elites after Chile's 2010 earthquake and tsunami. Drawing on media reports, we identify three distinct pairings of state/nature: (1) nature as manageable and the state as manager; (2) nature as out of control and the state as a police state; and (3) nature as financial opportunity and the state as prudential. Influenced by socioeconomic and historical factors, these state/nature pairings contradicted and reinforced one another in the disaster's aftermath and were deployed to reinforce top-down—rather than democratic—strategies of post-disaster reconstruction. This case offers an unusual approach to disaster politics by tracing how entwined and power-laden categories of state and nature condition the governance of disaster reconstruction processes. Key words: disaster, state, nature, socionature, political ecology of hazards, media disaster, earthquake, Latin America, Chile, 27

    New insights into the genetic etiology of Alzheimer's disease and related dementias

    Get PDF
    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele

    New insights into the genetic etiology of Alzheimer’s disease and related dementias

    No full text
    Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)

    CMS : the TriDAS Project Technical Design Report; v.1, the Trigger Systems

    No full text
    CM
    corecore