4,205 research outputs found
Professorial roles: a study of the professorial populations within nursing and midwifery, social work and allied health professions
The professorial populations in nursing/midwifery, social work and allied health are relatively new in academia compared to longer established professions such as medicine and dentistry. Less is known about the roles, career pathways, characteristics and career aspirations of the professoriate within these emerging professions.
A survey was undertaken from sample populations in each of the three professorial groups in order to obtain qualitative and quantitative data on professorial roles and activities, career pathway information and support mechanisms for professorial positions. This paper discusses the findings of the survey which relate specifically to professorial roles and activities and whether the identified roles reflect the professorial activities proposed by the National Conference of University Professors (NCUP)
Other aspects of this survey including career pathways, findings relating to gender and support mechanisms will form the basis of future papers.
Result
The effect of machining and induced surface deformation on the fatigue performance of a high strength metastable β titanium alloy
Metastable beta titanium alloys such as Ti-5Al-5Mo-5V-3Cr (Ti-5553) are used for large aero-structural components. During processing these alloys are subject to costly machining operations. There is an industry demand to machine at improved metal removal rates (MRR) to meet increasing aircraft orders. To understand the effects of MRR on subsurface deformation and fatigue performance, fatigue coupons were end milled under two different industrial conditions. The surface roughness, residual stress and subsurface deformation was characterised and a custom four point bend fatigue testing was designed to determine the effect of MMR on cycles to failure. The study has demonstrated that an increase in MMR of 50% resulted in a LCF reduction of 57.37%. This was a direct result of increased subsurface damage and residual stresses
Perceptions of the intergroup structure and anti-Asian prejudice amongst white Australians
Proof oSubjective intergroup beliefs and authoritarianism were assessed in a field study (N= 255) of White Australians’ anti-Asian stereotyping and prejudice. A social identity analysis of intergroup prejudice was adopted, such that perceptions of the intergroup structure (instability, permeability, legitimacy and higher ingroup status) were proposed as predictors of higher prejudice (blatant and covert) and less favorable stereotyping. Consistent with the social identity approach, both independent and interacting roles for sociostructural predictors of Anti-Asian bias were observed, even after demographic and personality variables were controlled. For example, perceived legitimacy was associated with higher prejudice when White Australians’ status position relative to Asian Australians was valued. Moreover, when participants evaluated Whites’ position as unstable and high status or legitimate, perceptions of permeable intergroup boundaries were associated with anti-Asian bias. The present findings demonstrate status protection responses in advantaged group members in a field setting, lending weight to the contention that perceptions of sociostructural threat interact to predict outgroup derogation. Implications for theories of intergroup relations are discussed
Quantized Response and Topology of Insulators with Inversion Symmetry
We study three dimensional insulators with inversion symmetry, in which other
point group symmetries, such as time reversal, are generically absent. Their
band topology is found to be classified by the parities of occupied states at
time reversal invariant momenta (TRIM parities), and by three Chern numbers.
The TRIM parities of any insulator must satisfy a constraint: their product
must be +1. The TRIM parities also constrain the Chern numbers modulo two. When
the Chern numbers vanish, a magneto-electric response parameterized by "theta"
is defined and is quantized to theta= 0, 2pi. Its value is entirely determined
by the TRIM parities. These results may be useful in the search for magnetic
topological insulators with large theta. A classification of inversion
symmetric insulators is also given for general dimensions. An alternate
geometrical derivation of our results is obtained by using the entanglement
spectrum of the ground state wave-function.Comment: 12 pages main text; 12 pages appendices; 11 figures. Added new refs.
in 2nd versio
The ASCA X-Ray Spectrum Of The Broad-Line Radio Galaxy Pictor A: A Simple Power Law With No Fe K-alpha Line
We present the X-ray spectrum of the broad-line radio galaxy Pictor A as
observed by ASCA in 1996. The main objective of the observation was to detect
and study the profiles of the Fe~K lines. The motivation was the fact
that the Balmer lines of this object show well-separated displaced peaks,
suggesting an origin in an accretion disk. The 0.5-10 keV X-ray spectrum is
described very well by a model consisting of a power law of photon index 1.77
modified by interstellar photoelectric absorption. We find evidence for neither
a soft nor a hard (Compton reflection) excess. More importantly, we do not
detect an Fe K-alpha line, in marked contrast with the spectra of typical
Seyfert galaxies and other broad-line radio galaxies observed by ASCA. The
99%-confidence upper limit on the equivalent width of an unresolved line at a
rest energy of 6.4 keV is 100 eV, while for a broad line (FWHM of approximately
60,000 km/s) the corresponding upper limit is 135 eV. We discuss several
possible explanations for the weakness of the Fe K-alpha line in Pictor~A
paying attention to the currently available data on the properties of Fe
K-alpha lines in other broad-line radio galaxies observed by ASCA. We speculate
that the absence of a hard excess (Compton reflection) or an Fe K-alpha line is
an indication of an accretion disk structure that is different from that of
typical Seyfert galaxies, e.g., the inner disk may be an ion torus.Comment: To appear in the Astrophysical Journal (18 pages, including 8
postscript figures; uses psfig.tex
The KX method for producing K-band flux-limited samples of quasars
The longstanding question of the extent to which the quasar population is
affected by dust extinction, within host galaxies or galaxies along the line of
sight, remains open. More generally, the spectral energy distributions of
quasars vary significantly and flux-limited samples defined at different
wavelengths include different quasars. Surveys employing flux measurements at
widely separated wavelengths are necessary to characterise fully the spectral
properties of the quasar population. The availability of panoramic
near-infrared detectors on large telescopes provides the opportunity to
undertake surveys capable of establishing the importance of extinction by dust
on the observed population of quasars. We introduce an efficient method for
selecting K-band, flux-limited samples of quasars, termed ``KX'' by analogy
with the UVX method. This method exploits the difference between the power-law
nature of quasar spectra and the convex spectra of stars: quasars are
relatively brighter than stars at both short wavelengths (the UVX method) and
long wavelengths (the KX method). We consider the feasibility of undertaking a
large-area KX survey for damped Ly-alpha galaxies and gravitational lenses
using the planned UKIRT wide-field near-infrared camera.Comment: 6 pages, 3 figures, to appear in MNRA
Expression and Purification of a Cleavable Recombinant Fortilin from \u3ci\u3eEscherichia coli\u3c/i\u3e for Structure Activity Studies
Complications related to atherosclerosis account for approximately 1 in 4 deaths in the United States and treatment has focused on lowering serum LDL-cholesterol levels with statins. However, approximately 50% of those diagnosed with atherosclerosis have blood cholesterol levels within normal parameters. Human fortilin is an anti-apoptotic protein and a factor in macrophage-mediated atherosclerosis and is hypothesized to protect inflammatory macrophages from apoptosis, leading to subsequent cardiac pathogenesis. Fortilin is unique because it provides a novel drug target for atherosclerosis that goes beyond lowering cholesterol and utilization of a solution nuclear magnetic resonance (NMR) spectroscopy, structure-based drug discovery approach requires milligram quantities of pure, bioactive, recombinant fortilin. Here, we designed expression constructs with different affinity tags and protease cleavage sites to find optimal conditions to obtain the quantity and purity of protein necessary for structure activity relationship studies. Plasmids encoding fortilin with maltose binding protein (MBP), 6-histidine (6His) and glutathione-S-transferase (GST), N- terminal affinity tags were expressed and purified from Escherichia coli (E. coli). Cleavage sites with tobacco etch virus (TEV) protease and human rhinovirus (HRV) 3C protease were assessed. Despite high levels of expression of soluble protein, the fusion constructs were resistant to proteinases without the inclusion of amino acids between the cleavage site and N-terminus. We surveyed constructs with increasing lengths of glycine/serine (GGS) linkers between the cleavage site and fortilin and found that inclusion of at least one GGS insert led to successful protease cleavage and pure fortilin with conserved binding to calcium as measured by NMR
Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream. Contrasting with previously reported mechanisms of intracellular pathogen carriage by phagocytes, we show S. pyogenes remain extracellular during transit, first in afferent and then efferent lymphatics that carry the bacteria through successive draining lymph nodes. We identify streptococcal virulence mechanisms important for bacterial lymphatic dissemination and show that metastatic streptococci within infected lymph nodes resist and subvert clearance by phagocytes, enabling replication that can seed intense bloodstream infection. The findings establish the lymphatic system as both a survival niche and conduit to the bloodstream for S. pyogenes, explaining the phenomenon of occult bacteraemia. This work provides new perspectives in streptococcal pathogenesis with implications for immunity
A candidate tolerance gene identified in a natural population of field voles (Microtus agrestis)
The animal immune response has hitherto been viewed primarily in the context of resistance only. However, individuals, can also employ a tolerance strategy to maintain good health in the face of on-going infection. To shed light on the genetic and physiological basis of tolerance, we use a natural population of field voles, Microtus agrestis, to search for an association between the expression of the transcription factor Gata3, previously identified as a marker of tolerance in this system, and polymorphism in 84 immune and non-immune genes. Our results show clear evidence for an association between Gata3 expression and polymorphism in the Fcer1a gene, with the explanatory power of this polymorphism being comparable to that of other non-genetic variables previously identified as important predictors of Gata3 expression. We also uncover the possible mechanism behind this association using an existing protein-protein interaction network for the mouse model rodent, Mus musculus, which we validate using our own expression network for M. agrestis. Our results suggest that the polymorphism in question may be working at the transcriptional level, leading to changes in the expression of the Th2-related genes, Tyrosine-protein kinase BTK and Tyrosine-protein kinase TXK, and hence potentially altering the strength of the Th2 response, of which Gata3 is a mediator. We believe our work has implications for both treatment and control of infectious disease
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