Observations on Regularization and the Labor Market Performance of Unauthorized and Regularized Immigrants

Task Force Policy Brief No. 4. This author argues that legalization (or "regularization" in Europe) of unauthorized migrants can not only prevent the illegally resident population from building to unacceptable levels, but can also make the management of migration more effective when used in concert with other policy initiatives

Entropies, level-density parameters, and fission probabilities along the triaxially- and axially-symmetric fission paths in 296^{296}Lv

We employ a statistical approach to investigate the influence of axial asymmetry on the nuclear level density and entropy along the fission pathways of a superheavy nucleus, explicitly focusing on the $^{296}$Lv isotope. These pathways are determined within multidimensional deformation spaces. Our analysis reveals a significant impact of triaxiality on entropy. Additionally, suppressing shell effects can alter the fission scenario depending on the available excitation energy. We derive the deformation-dependent level density parameter, which plays a crucial role in estimating the survival probability of a superheavy nucleus. Furthermore, we utilize a set of master equations to obtain the time-dependent fission probabilities and calculate the ratio of decay probabilities for both axial and triaxial paths.Comment: submitted to PR

Multi-step particle emission probabilities in superheavy nuclei at moderate excitation energies

The probabilities of $xn$-, $pxn$-, and $\alpha xn$-evaporation channels in excited superheavy nuclei were evaluated using the Monte Carlo method. The calculations utilized microscopically determined nuclear level densities and were compared with results obtained from the phenomenological Jackson formula. Effective temperatures derived from the microscopic approach were incorporated into the Jackson formula for different evaporation channels at low and moderate excitation energies. Additionally, an analytical formula was introduced to estimate the average kinetic energy of emitted particles in multi-step processes.Comment: 10 pages, 3 figure

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

Background: The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the need for the development of novel targeted therapies for this tumor subtype. Methods: Our group previously showed that EZH2 is functionally relevant in BRCA1-deficient breast tumors and blocking EZH2 enzymatic activity could be a potent treatment strategy. To validate the role of EZH2 as a therapeutic target and to identify new synergistic drug combinations, we performed a high-throughput drug combination screen in various cell lines derived from BRCA1-deficient and -proficient mouse mammary tumors. Results: We identified the combined inhibition of EZH2 and the proximal DNA damage response kinase ATM as a novel synthetic lethality-based therapy for the treatment of BRCA1-deficient breast tumors. We show that the combined treatment with the EZH2 inhibitor GSK126 and the ATM inhibitor AZD1390 led to reduced colony formation, increased genotoxic stress, and apoptosis-mediated cell death in BRCA1-deficient mammary tumor cells in vitro. These findings were corroborated by in vivo experiments showing that simultaneous inhibition of EZH2 and ATM significantly increased anti-tumor activity in mice bearing BRCA1-deficient mammary tumors. Conclusion: Taken together, we identified a synthetic lethal interaction between EZH2 and ATM and propose this synergistic interaction as a novel molecular combination for the treatment of BRCA1-mutant breast cancer.Toxicolog

Design and Strength Analysis of Curved-Root Concept for Compressor Rotor Blade in Gas Turbine

The motivation of the article is fatigue and fretting issue of the compressor rotor blades and disks. These phenomena can be caused by high contact pressures leading to fretting occurring on contact faces in the lock (blade-disk connection, attachment of the blade to the disk). Additionally, geometrical notches and high cyclic loading can initiate cracks and lead to engine failures. The paper presents finite element static and modal analyses of the axial compressor 3rd for the original trapezoidal/dovetail lock geometry and its two modifications (new lock concepts) to optimize the stress state of the disk-blade assembly. The cyclic symmetry formulation was used to reduce modelling and computational effort

Comparison of the dynamic riveting process of a rivet with and without a compensator

The paper deals with the analysis of deformation of a rivet hole in a riveted joint after the manual dynamic riveting process. For many years, riveting remains a traditional and the most popular method of joining in aircraft structures. The residual stress and strain state appear at the rivet hole after the riveting process, which improves the joint's fatigue behaviour. The local finite element models are made with Patron. The rivet and sheets are described using eight-noded, three-dimensional brick elements. The riveting tools consist of four-noded, two-dimensional shell elements. Numerical FE simulations of the upsetting process are carried out using the Ls-Dyna code. The contact with friction is defined between the collaborating parts of the specimen. The results of simulations of the dynamic riveting process of a mushroom rivet with and without a compensator are compared in this paper. Hole deformation of the upper and lower sheet, squeezing force, as well as deformations of the rivet head are analysed. The influence of the compensator on strain and displacement states is studied. Simulation shows that some technological factors may have positive influence on the residual stress fields. Using the rivet with a compensator results in a better rivet hole filling capability. The rivet hole displacement in upper and lower sheets are at the same level. Paper also present manual dynamic riveting process ofreverse and standard riveting procedure and model of riveted specimen