Kinetic Laws and Mechanism of Interaction between Ligands and Receptors. Acetylcholine Receptor of Muscarinic Type

Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Statistical analysis of protein kinase specificity determinants

AbstractThe site and sequence specificity of protein kinases, as well as the role of the secondary structure and surface accessibility of the phosphorylation sites on substrate proteins, was statistically analyzed. The experimental data were collected from the literature and are available on the World Wide Web at http://www.cbs.dtu.dk/databases/PhosphoBase/. The set of data involved 1008 phosphorylatable sites in 406 proteins, which were phosphorylated by 58 protein kinases. It was found that there exists almost absolute Ser/Thr or Tyr specificity, with rare exceptions. The sequence specificity determinants were less strict and were located between positions −4 and +4 relative to the phosphorylation site. Secondary structure and surface accessibility predictions revealed that most of the phosphorylation sites were located on the surface of the target proteins

Integrating ecosystem services into decision support for management of agroecosystems: Viva Grass tool

The area covered by low-input agroecosystems (e.g. semi-natural and permanent grasslands) in Europe has considerably decreased throughout the last century. To support more sustainable management practices, and to promote biodiversity and ecosystem service values of such agroecosystems a decision support tool was developed. The tool aims to enhance the operationalization of ecosystem services and address the challenge of their integration into spatial planning. The Viva Grass tool aims to enhance the maintenance of ecosystem services delivered by low-input agroecosystems. It does so by providing spatially explicit decision support for land-use planning and sustainable management of agroecosystems. The Viva Grass tool is a multi-criteria decision analysis tool for integrated planning. It is designed for farmers, spatial planners and policy makers to support decisions of management of agroecosystems. The tool has been tested to assess spatial planning in eight case studies across the Baltic States