Nuclear Segmentation, Condensation and Bilateral Symmetry in Polymorphonuclear Leukocytes Reflect Genomic Order and Favor Immunologic Function

Segmentation, condensation and bilateral symmetry of the nuclei ofpolymorphonuclear leukocytes seem related to their function.Segmentation of the nuclei into two or more lobes and their condensationfacilitate their passage (diapedesis) through the endothelial layer ofblood vessels to the extravasal space and subsequent locomotion throughthe interstitial compartment of different tissues. Bilateral symmetry ofthese nuclei along with their association to the cytoskeletal fiberscontribute to their efficiency in locomotion by alignment of the axis ofnuclear symmetry to the axis of cellular polarity, which orients towardsthe direction of locomotion in response to cytokines and other stimuli.Observations of the cytogenetic facets of intranuclear order supportthese assumptions

Preparation Of Perovskite Pb(Mg1/3Nb2/3)03 Using Pb3Nb208 And MgO

The synthesis of perovskite Pb(Mg1/3Nb2/3)O3 from an equimolar mixture of Pb3Nb208 and MgO was studied by solid‐state reaction techniques. An addition of 1 wt% excess MgO to the stoichiometric composition enhances the formation of the cubic perovskite phase. The absence of free PbO in the initial starting materials minimizes the volatilization loss during firing, thereby reducing the possibility of any compositional change and resulting in a substantial improvement of the perovskite phase purity over the conventional mixed‐oxide processing. Copyright © 1986, Wiley Blackwell. All rights reserve

Reaction During Sintering Of Barium Titanate With Lithium Fluoride

The reactions occurring during sintering of stoichiometric BaTiO3 with small additions of LiF were studied at temperatures between 700° and 900°C. BaTiO3 reacts with LiF to form a cubic solid solution and Li2TiO3 During sintering, the cubic solid solution coexists with Li2Ti03 and forms a liquid phase at 740°± 5°C. The occurrence of a liquid phase at this temperature results in an enhancement of the sintering process and leads to the development of a highly dense microstructure. Copyright © 1986, Wiley Blackwell. All rights reserve

A complete description of the magnetic ground state in spinel vanadates

Capturing the non-collinear magnetic ground state of the spinel vanadates AV$_2$O$_4$ (A= Mn, Fe and Co) remains an outstanding challenge for state-of-the-art ab-initio methods. We demonstrate that both the non-collinear spin texture, as well as the magnitude of local moments, are captured by a single value of the on-site Hubbard $U$ of 2.7~eV in conjunction with the local spin density approximation (LSDA+$U$), provided the source term (i.e., magnetic monopole term) is removed from the exchange-correlation magnetic field ${\bf B}_{XC}$. We further demonstrate that the magnetic monopole structure in ${\bf B}_{XC}$ is highly sensitive to the value of $U$, to the extent that the interplay between on-site localization and local moment magnitude is qualitatively different depending on whether the source term is removed or not. This suggests that in treating strongly correlated magnetic materials within the LSDA+$U$ formalism, subtraction of the unphysical magnetic monopole term from the exchange-correlation magnetic field is essential to correctly treat the magnetic ground state.Comment: 4 pages, 3 figure

Pharmacovigilance programme of India: revival of the renaissance

Adverse drug reactions (ADRs) are the fourth leading cause of morbidity in the world. In order to safeguard the health of the community, Pharmacovigilance Programme of India (PvPI) is implemented as the monitoring body by Indian Pharmacopoeia Commission (IPC). It is leading national authority. National Coordinating Centre (NCC) PvPI works as the World Health Organization (WHO) collaborating centre for pharmacovigilance. Adverse drug reactions are reported to NCC PvPI which are then directed towards WHO Uppsala Monitoring Centre (UMC) Sweden which is the global monitoring centre for worldwide data. Central Drugs Standard Control Organization (CDSCO) is the regulatory authority of India under the Ministry of Health and Family Welfare (MOHFW), Government of India. This article focusses on the various strands of pharmacovigilance at the healthcare professional and consumer level. It also discusses the pitfalls in the journey of pharmacovigilance thus helping in enhancing the quality of health safety. Even a minuscule contribution by a health care professional or a consumer can voluminously help in promotion of drug safety. Therefore, there is a need of inculcating the culture of adverse drug reaction reporting for the welfare of the vulnerable masses

Nuclear Segmentation, Condensation and Bilateral Symmetry in Polymorphonuclear Leukocytes Reflect Genomic Order and Favor Immunologic Function

Segmentation, condensation and bilateral symmetry of the nuclei ofpolymorphonuclear leukocytes seem related to their function.Segmentation of the nuclei into two or more lobes and their condensationfacilitate their passage (diapedesis) through the endothelial layer ofblood vessels to the extravasal space and subsequent locomotion throughthe interstitial compartment of different tissues. Bilateral symmetry ofthese nuclei along with their association to the cytoskeletal fiberscontribute to their efficiency in locomotion by alignment of the axis ofnuclear symmetry to the axis of cellular polarity, which orients towardsthe direction of locomotion in response to cytokines and other stimuli.Observations of the cytogenetic facets of intranuclear order supportthese assumptions

Web3 Chain Authentication and Authorization Security Standard (CAA)

Web3 is the next evolution of the internet, which uses blockchains, cryptocurrencies, and NFTs to return ownership and authority to the consumers. The potential of Web3 is highlighted by the creation of decentralized applications (dApps), which are more secure, transparent, and tamper-proof than their centralized counterparts, allowing for new business models that were previously impossible on the traditional internet.Web3 also focuses on user privacy, where users have more control over their personal data and can choose to share only what they want. The emergence of Web3 represents an exciting new frontier in blockchain technology, and its focus on decentralization, user privacy, and trustless systems has the potential to transform the way we interact with the internet.Web3 authentication is required for enhanced security, increased privacy, and simplified user interface. Traditional login procedures and an authorization flow using web3 authentication work together seamlessly. However, there are several challenges associated with Web3, including scalability and regulatory issues. Chain Authentication and Authorization (CAA) is a multi-layer security mechanism that allows users to choose the security layer that suits them, just like a heavy iron chain, where the user and CAA developers act as blacksmith and form their security protocol that suits them. CAA is a solution to the challenges associated with Web3 authentication and authorization, and it focuses on creating a secure and decentralized authentication and authorization system that is scalable, flexible, and user-friendly

Focal Segmental Glomerulosclerosis Complicating Therapy With Inotersen, an Antisense Oligonucleotide Inhibitor: A Case Report

Inotersen is an antisense oligonucleotide inhibitor licensed for the treatment of polyneuropathy complicating hereditary transthyretin amyloidosis (ATTRv). Nephrotoxicity has been reported with inotersen, including progression to end stage renal disease. We describe the first reported case of inotersen-associated nephrotic syndrome secondary to focal segmental glomerulosclerosis (FSGS) and review the literature concerning inotersen-induced nephrotoxicity. We report a woman in her early 30s with ATTRv associated with the (p.V50M) transthyretin (TTR) variant, who presented with nephrotic syndrome 7 months after commencement of inotersen. Renal histology demonstrated focal segmental glomerulosclerosis and scanty glomerular amyloid deposition. Discontinuation of inotersen alone resulted in complete clinical and biochemical resolution of nephrotic syndrome. Inotersen is associated with significant nephrotoxicity. In the phase III NEURO-TTR clinical trial, 3% of patients in the treatment arm developed a crescentic glomerulonephritis. All affected patients carried the (p.V50M) TTR variant which is known to be associated with renal amyloid deposition. This case adds to spectrum of renal disease associated with inotersen and indicates that discontinuation of the drug alone may result in resolution of renal complications without additional immunosuppression. Monitoring of renal function is essential in patients with ATTRv receiving inotersen, particularly if there is evidence of existing renal amyloid

On the Functional Relationship Between Fluorescence and Photochemical Yields in Complex Evergreen Needleleaf Canopies

Recent advancements in understanding remotely sensed solar‐induced chlorophyll fluorescence often suggest a linear relationship with gross primary productivity at large spatial scales. However, the quantum yields of fluorescence and photochemistry are not linearly related, and this relationship is largely driven by irradiance. This raises questions about the mechanistic basis of observed linearity from complex canopies that experience heterogeneous irradiance regimes at subcanopy scales. We present empirical data from two evergreen forest sites that demonstrate a nonlinear relationship between needle‐scale observations of steady‐state fluorescence yield and photochemical yield under ambient irradiance. We show that accounting for subcanopy and diurnal patterns of irradiance can help identify the physiological constraints on needle‐scale fluorescence at 70–80% accuracy. Our findings are placed in the context of how solar‐induced chlorophyll fluorescence observations from spaceborne sensors relate to diurnal variation in canopy‐scale physiology