3,745 research outputs found
The Changes in China's Forests: An Analysis Using the Forest Identity
Changes in forest carbon stocks are a determinant of the regional carbon budget. In the past several decades, China has experienced a pronounced increase in forest area and density. However, few comprehensive analyses have been conducted. In this study, we employed the Forest Identity concept to evaluate the changing status of China's forests over the past three decades, using national forest inventory data of five periods (1977–1981, 1984–1988, 1989–1993, 1994–1998, and 1999–2003). The results showed that forest area and growing stock density increased by 0.51% and 0.44% annually over the past three decades, while the conversion ratio of forest biomass to growing stock declined by 0.10% annually. These developments resulted in a net annual increase of 0.85% in forest carbon sequestration, which is equivalent to a net biomass carbon uptake of 43.8 Tg per year (1 Tg = 1012 g). This increase can be attributed to the national reforestation/afforestation programs, environmentally enhanced forest growth and economic development as indicated by the average gross domestic product
Development and initial psychometric properties of the Warwick–Edinburgh Mental Wellbeing Scale-Intellectual Disability version
Background: The Warwick–Edinburgh Mental Wellbeing Scale (WEMWBS; Tennant et al., 2007) is yet to be validated in the intellectual disability (ID) population. The aim of this study was to report the development process and assess the psychometric properties of a newly adapted version of the WEMWBS and the Short WEMWBS for individuals with mild to moderate IDs (WEMWBS-ID/SWEMWBS-ID). / Method: The WEMWBS item wordings and response options were revised by clinicians and researchers expert in the field of ID, and a visual aid was added to the scale. The adapted version was reviewed by 10 individuals with IDs. The measure was administered by researchers online using screenshare, to individuals aged 16+ years with mild to moderate IDs. Data from three UK samples were collated to evaluate the WEMWBS-ID (n = 96). A subsample (n = 22) completed the measure again 1 to 2 weeks later to assess test–retest reliability, and 95 participants additionally completed an adapted version of the adapted Rosenberg Self-Esteem Scale to examine convergent validity. Additional data from a Canadian sample (n = 27) were used to evaluate the SWEMWBS-ID (n = 123). / Results: The WEMWBS-ID demonstrated good internal consistency (ω = 0.77–0.87), excellent test–retest reliability [intraclass correlation coefficient (ICC) =.88] and good convergent validity with the self-esteem scale (r =.48–.60) across samples. A confirmatory factor analysis for a single factor model demonstrated an adequate fit. The SWEMWBS-ID showed poor to good internal consistency (ω = 0.36–0.74), moderate test–retest reliability (ICC =.67) and good convergent validity (r =.48–.60) across samples, and a confirmatory factor analysis indicated good model fit for a single factor structure. / Conclusions: The WEMWBS-ID and short version demonstrated promising psychometric properties, when administered virtually by a researcher. Further exploration of the scales with larger, representative samples is warranted
The development of meibomian glands in mice
PurposeThe purpose of this study was to characterize the natural history of meibomian gland morphogenesis in the mouse.MethodsEmbryonic (E) and post natal (P) C57Bl/6 mouse pups were obtained at E18.5, P0, P1, P3, P5, P8, P15, and P60. Eyelids were fixed and processed for en bloc staining with Phalloidin/DAPI to identify gland morphogenesis, or frozen for immunohistochemistry staining with Oil red O (ORO) to identify lipid and antibodies specific against peroxisome proliferator-activated receptor gamma (PPARÎł) to identify meibocyte differentiation. Samples were then evaluated using a Zeiss 510 Meta laser scanning confocal microscope or Nikon epi-fluorescent microscope. Tissues from adult mice (2 month-old) were also collected for western blotting.ResultsMeibomian gland morphogenesis was first detected at E18.5 with the formation of an epithelial placode within the fused eyelid margin. Invagination of the epithelium into the eyelid was detected at P0. From P1 to P3 there was continued extension of the epithelium into the eyelid. ORO and PPARÎł staining was first detected at P3, localized to the central core of the epithelial cord thus forming the presumptive ductal lumen. Ductal branching was first detected at P5 associated with acinar differentiation identified by ORO and PPARÎł staining. Adult meibomian glands were observed by P15. Western blotting of meibomian gland proteins identified a 50 kDa and a 72 kDa band that stained with antibodies specific to PPARÎł.ConclusionsWe have demonstrated that meibomian gland development bears distinct similarities to hair development with the formation of an epithelial placode and expression of PPARÎł co-incident with lipid synthesis and meibocyte differentiation
Low-grade pelvic masses with spindle cell and fibroblastic proliferation: a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Garment smoothness appearance evaluation through computer vision
The measurement and evaluation of the appearance of wrinkling in textile products after domestic washing and drying is performed currently by the comparison of the fabric with the replicas. This kind of evaluation has certain drawbacks, the most significant of which are its subjectivity and its limitations when used with garments. In this paper, we present an automated wrinkling evaluation system. The system developed can process fabrics as well as any type of garment, independent of size or pattern on the material. The system allows us to label different parts of the garment. Thus, as different garment parts have different influence on human perception, this labeling enables the use of weighting, to improve the correlation with the human visual system. The system has been tested with different garments showing good performance and correlation with human perception. © The Author(s) 2012.Silvestre-Blanes, J.; Berenguer Sebastiá, JR.; Pérez Llorens, R.; Miralles, I.; Moreno Canton, J. (2012). Garment smoothness appearance evaluation through computer vision. Textile Research Journal. 82(3):299-309. doi:10.1177/0040517511424530S299309823López, F., Miguel Valiente, J., Manuel Prats, J., & Ferrer, A. (2008). Performance evaluation of soft color texture descriptors for surface grading using experimental design and logistic regression. Pattern Recognition, 41(5), 1744-1755. doi:10.1016/j.patcog.2007.09.011Villette, S. (2008). Simple imaging system to measure velocity and improve the quality of fertilizer spreading in agriculture. Journal of Electronic Imaging, 17(3), 031109. doi:10.1117/1.2956835Neri, F., & Tirronen, V. (2009). Memetic Differential Evolution Frameworks in Filter Design for Defect Detection in Paper Production. Studies in Computational Intelligence, 113-131. doi:10.1007/978-3-642-01636-3_7Carfagni, M., Furferi, R., & Governi, L. (2005). A real-time machine-vision system for monitoring the textile raising process. Computers in Industry, 56(8-9), 831-842. doi:10.1016/j.compind.2005.05.010Wang, W., Wong, Y. S., & Hong, G. S. (2005). Flank wear measurement by successive image analysis. Computers in Industry, 56(8-9), 816-830. doi:10.1016/j.compind.2005.05.009Cho, C.-S., Chung, B.-M., & Park, M.-J. (2005). Development of Real-Time Vision-Based Fabric Inspection System. IEEE Transactions on Industrial Electronics, 52(4), 1073-1079. doi:10.1109/tie.2005.851648Kawabata, S., Mori, M., & Niwa, M. (1997). An experiment on human sensory measurement and its objective measurement. International Journal of Clothing Science and Technology, 9(3), 203-206. doi:10.1108/09556229710168324Fan, J., Lu, D., Macalpine, J. M. K., & Hui, C. L. P. (1999). Objective Evaluation of Pucker in Three-Dimensional Garment Seams. Textile Research Journal, 69(7), 467-472. doi:10.1177/004051759906900701Fan, J., & Liu, F. (2000). Objective Evaluation of Garment Seams Using 3D Laser Scanning Technology. Textile Research Journal, 70(11), 1025-1030. doi:10.1177/004051750007001114Yang, X. B., & Huang, X. B. (2003). Evaluating Fabric Wrinkle Degree with a Photometric Stereo Method. Textile Research Journal, 73(5), 451-454. doi:10.1177/004051750307300513Kang, T. J., Kim, S. C., Sul, I. H., Youn, J. R., & Chung, K. (2005). Fabric Surface Roughness Evaluation Using Wavelet-Fractal Method. Textile Research Journal, 75(11), 751-760. doi:10.1177/0040517505058855Mohri, M., Ravandi, S. A. H., & Youssefi, M. (2005). Objective evaluation of wrinkled fabric using radon transform. Journal of the Textile Institute, 96(6), 365-370. doi:10.1533/joti.2004.0066Zaouali, R., Msahli, S., El Abed, B., & Sakli, F. (2007). Objective evaluation of multidirectional fabric wrinkling using image analysis. Journal of the Textile Institute, 98(5), 443-451. doi:10.1080/00405000701489156Yu, W., Yao, M., & Xu, B. (2009). 3-D Surface Reconstruction and Evaluation of Wrinkled Fabrics by Stereo Vision. Textile Research Journal, 79(1), 36-46. doi:10.1177/004051750809049
Regular mass screening for SARS-CoV-2 infection in care homes already affected by COVID-19 outbreaks: Implications of false positive test results
Differential Calcium Signaling by Cone Specific Guanylate Cyclase-Activating Proteins from the Zebrafish Retina
Zebrafish express in their retina a higher number of guanylate cyclase-activating proteins (zGCAPs) than mammalians pointing to more complex guanylate cyclase signaling systems. All six zGCAP isoforms show distinct and partial overlapping expression profiles in rods and cones. We determined critical Ca2+-dependent parameters of their functional properties using purified zGCAPs after heterologous expression in E.coli. Isoforms 1–4 were strong, 5 and 7 were weak activators of membrane bound guanylate cyclase. They further displayed different Ca2+-sensitivities of guanylate cyclase activation, which is half maximal either at a free Ca2+ around 30 nM (zGCAP1, 2 and 3) or around 400 nM (zGCAP4, 5 and 7). Zebrafish GCAP isoforms showed also differences in their Ca2+/Mg2+-dependent conformational changes and in the Ca2+-dependent monomer-dimer equilibrium. Direct Ca2+-binding revealed that all zGCAPs bound at least three Ca2+. The corresponding apparent affinity constants reflect binding of Ca2+ with high (≤100 nM), medium (0.1–5 µM) and/or low (≥5 µM) affinity, but were unique for each zGCAP isoform. Our data indicate a Ca2+-sensor system in zebrafish rod and cone cells supporting a Ca2+-relay model of differential zGCAP operation in these cells
Hypofractionated radiotherapy has the potential for second cancer reduction
<p>Abstract</p> <p>Background and Purpose</p> <p>A model for carcinoma and sarcoma induction was used to study the dependence of carcinogenesis after radiotherapy on fractionation.</p> <p>Materials and methods</p> <p>A cancer induction model for radiotherapy doses including fractionation was used to model carcinoma and sarcoma induction after a radiation treatment. For different fractionation schemes the dose response relationships were obtained. Tumor induction was studied as a function of dose per fraction.</p> <p>Results</p> <p>If it is assumed that the tumor is treated up to the same biologically equivalent dose it was found that large dose fractions could decrease second cancer induction. The risk decreases approximately linear with increasing fraction size and is more pronounced for sarcoma induction. Carcinoma induction decreases by around 10% per 1 Gy increase in fraction dose. Sarcoma risk is decreased by about 15% per 1 Gy increase in fractionation. It is also found that tissue which is irradiated using large dose fractions to dose levels lower than 10% of the target dose potentially develop less sarcomas when compared to tissues irradiated to all dose levels. This is not observed for carcinoma induction.</p> <p>Conclusions</p> <p>It was found that carcinoma as well as sarcoma risk decreases with increasing fractionation dose. The reduction of sarcoma risk is even more pronounced than carcinoma risk. Hypofractionation is potentially beneficial with regard to second cancer induction.</p
Ablation of prion protein immunoreactivity by heating in saturated calcium hydroxide
<p>Abstract</p> <p>Background</p> <p>Prions, the infectious agents that cause transmissible spongiform encephalopathies (TSEs), are relatively resistant to destruction by physical, enzymatic, and chemical treatments. Hydrolysis in boiling saturated calcium hydroxide (limewater) utilizes inexpensive chemicals to digest protein components of offal. The purpose of this work was to determine if incubating brain material from scrapie-infected sheep in near-boiling saturated calcium hydroxide solution (Ca(OH)<sub>2</sub>) would abolish immunoreactivity of the infectious prion (PrP<sup>Sc</sup>) as determined by western blot.</p> <p>Findings</p> <p>After incubating for as few as 10 minutes in saturated calcium hydroxide at 99°C, immunoreactivity of protease resistant bands by western blot analysis is completely lost.</p> <p>Conclusion</p> <p>Boiling in limewater may offer an alternative for disposal of carcasses and enable alternative uses for rendered products from potentially infected carcasses.</p
Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses
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