7 research outputs found

    Chemical composition and anti-diabetic properties of Jatropha curcas leaves extract on alloxan induced diabetic wistar rats

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    This study evaluates the chemical composition and anti-diabetic properties of fresh and shade dried Jatropha curcas aqueous leaves extracts (JCLE) on alloxan induced diabetic female wistar rats. Seven (7) kg of J. curcas leaves were pulverized and aqueous extracts produced. Thirty five (35) mature female rats were grouped into seven of five animals per group according to their body weights. Blood samples were collected for baseline data before inducing diabetes. Various groups of rats were fed graded doses (100, 200 and 300 mg of JCLE, respectively. Blood glucose was tested every seven days using glucometer. The animals were treated for 21 days with JCLE, blood samples were collected for liver enzyme function test, liver and pancreas tissues collected for histopathology. The results obtained were analysed statistically using analysis of variance (ANOVA) and Duncan Multiple range student test. Result shows that proximate composition of JCLE had higher protein, fat and carbohydrate concentrations in shade dried than the fresh samples. The vitamin, mineral and phytochemical compositions varied but higher in shade dried JCLE also than the fresh. Rats treated had significant (p<0.05) reduction in blood glucose level. Liver enzymes was higher with shade dried JCLE. The current study provides some useful insight into the anti-hyperglycemic potency of JCLE in alloxan induced diabetics and seems to repair some organs damages.Key words: Blood glucose, Jatropha curcus, liver enzymes, diabetic

    Chemical and organoleptic evaluation of soyabean-yam receipes as possible snacks and food for children

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    No Abstract. Bio-Research Vol. 4(1) 2006: 18-2

    Effects of Moringa oleifera Lam. aqueous leaf extracts on follicle stimulating hormone and serum cholesterol in Wistar rats

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    The study evaluated the effect of Moringa oleifera aqueous leaf extracts on follicle stimulating hormone and serum cholesterol in Wistar rats. Thirty six (36) mature Wistar rats (20 male and 16 female rats) were used. The male rats were grouped into four groups with five animals each, while the female animals were grouped into four made up of four animals per group, on the basis of their body weights. Graded doses (1, 5 and 10 g) aqueous extract were prepared from the Mo leaves as the test samples. In the first phase: The test extract was administered orally after acclimatization to individual groups: A-male and E-female rats, 1%; groups B-male and F-female rats, 5%; and groups C-male and F-female rats, 10%. These test groups also had rat chow and water ad libitum. The second phase of the experiment involved mating the male and female animals that had the same dose of M. oleifera extract. The results show that the mean body weights of the male rats increased significantly after treatment (p<0.05). The study also reveals that the administration of M. oleifera extract at different doses for the male and female rats differed significantly (p<0.05) with that of the control in raising the level of follicle stimulating hormone (FSH). A-1% increased by 38.52% while B-5% decreased (-21.20%); E-1% decreased (-12.96%) and F-5% (-25.64%). After mating, the % increase in FSH concentration was observed to be significantly (p<0.05) difference. Administration of Mo extract at different levels for the male and female rats differed significantly (p<0.05) in this study as compared with the control in lowering the total serum cholesterol of the rats. A-1% increased total cholesterol by 1.10%, while B-5% revealed a decrease of (-10.99%). Key words: Moringa oleifera, follicle stimulating hormone, serum cholesterol, Wistar rats
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