Polyunsaturated fatty acids modulate the association between PIK3CA-KCNMB3 genetic variants and insulin resistance

BACKGROUND:Neighboring genes PIK3CA and KCNMB3 are both important for insulin signaling and β-cell function, but their associations with glucose-related traits are unclear. OBJECTIVE:The objective was to examine associations of PIK3CA-KCNMB3 variants with glucose-related traits and potential interaction with dietary fat. DESIGN:We first investigated genetic associations and their modulation by dietary fat in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 820). Nine single-nucleotide polymorphisms (SNPs) were selected for analysis, covering more than 80% of the SNPs in the region. We then sought to replicate the findings in the Boston Puerto Rican Health Study (BPRHS) (n = 844). RESULTS:For KCNMB3 missense mutation rs7645550, meta-analysis indicated that homeostasis model assessment of insulin resistance (HOMA-IR) was significantly lower in minor allele T homozygotes compared with major allele C carriers (pooled P-value = 0.004); for another SNP rs1183319, which is in moderate LD with rs7645550, minor allele G carriers had higher HOMA-IR compared with non-carriers in both populations (pooled P-value = 0.028). In GOLDN, rs7645550 T allele homozygotes had lower HOMA-IR only when dietary n-3: n-6 PUFA ratio was low (≤0.11, P = 0.001), but not when it was high (>0.11, P-interaction = 0.033). Similar interaction was observed between rs1183319 and n-3: n-6 PUFA ratio on HOMA-IR (P-interaction = 0.001) in GOLDN. Variance contribution analyses in GOLDN confirmed the genetic association and gene-diet interaction. In BPRHS, dietary n-3: n-6 PUFA ratio significantly modulated the association between rs1183319 and HbA1c (P-interaction = 0.034). CONCLUSION:PIK3CA-KCNMB3 variants are associated with insulin resistance in populations of different ancestries, and are modified by dietary PUFA

Tracking the PM2.5 inventories embodied in the trade among China, Japan and Korea

Abstract Due to its long-term negative health effects and increasing emissions, the PM2.5 issue has caused rising concerns in recent years. Although official media from East Asian countries tend to avoid blaming PM emission sources on their neighboring countries, researches have proved the existence of pronounced long-range trans-boundary particulate matters transported by nature force and by human activities. In this context, this paper included the structural path analysis (SPA) to quantify trans-boundary PM2.5 at sector level, track its transaction paths and figure out the linkages between consumption and production responsibilities of China, Japan and Korea. Based on the results and policy reviews of current environmental cooperation mechanisms, this paper found that: Considering the China–Japan and China–Korea trades, China’s net exportation of embodied PM2.5 emissions has exceeded the importation rates over 10 times (CHN → JPN, 56.53 kt, JPN → CHN, 3.58 kt; CHN → KOR, 59.19 kt, KOR → CHN, 5.31 kt). Japan and Korea benefited from importing raw materials with high emission intensity from China to meet domestic consumption needs and keep a low national emission level. China, the largest emitter in the world, should first take the responsibility to mitigate its huge domestic PM2.5 emission. However, the relocated emissions from its neighboring countries should not be ignored. For Japan or Korea, due to the close economic interdependence and geographical position, any contribution to the reduction of the trans-boundary emissions or to the solution of atmosphere problems within China also helps those countries themselves. In the long run, all three countries would benefit from enhancing subregional environmental cooperation

yiyi1991/source_data_deposit_feasibility: source_data_deposit_feasibility

<p>The data and code for the research article "Perceived feasibility of a net-zero system transition and its potential barriers among Japanese experts". The research is conducted by Yiyi Ju, Masahiro Sugiyama, and Hiroto Shiraki.</p> <p>Data availability The anonymized data in the research article can be found in this repository. This will enable the reproduction of key figures. Anonymized data is available upon reasonable request.</p> <p>Code availability The code for analysis and visualization in the research article can be found in this repository. This will enable the reproduction of key figures (but not all including the supplemental figures, considering of the privacy, e.g., specific information, such as working experience, research field, and whether or not the person is an IPCC author, can help identify specific experts).</p&gt

Public perceptions on net zero energy houses in Japan

For Japan, which has not operated nearly all of its nuclear power plants since 2011 and is dependent on thermal power generation, the introduction of renewable energy into homes is extremely important for the future formation of a sustainable society. However, the introduction of net zero energy house (ZEH) in detached houses, which account for 55% of all dwellings in Japan, has not progressed. To promote the introduction of ZEH, this study clarified the awareness of owners of detached houses regarding ZEH. We analyzed factors that influence such perception of solar photovoltaics (PV) technology using a 1000-sample online survey questionnaire. The survey was conducted in late January 2020 and included questions examining the public perception of solar installation and factors that were found to be important in previous research. We found that Japanese respondents who live in detached houses generally lack an understanding of renewables and that the level of interest in installing solar PV for the ZEH is low. We also found that awareness of renewables, such as knowing new energy policy and searching information on solar PV, is the critical factor of installing renewables. At the same time, most socio-demographic and neighborhood variables seem not to influence installing solar PV or other technologies for ZEH. This research will contribute to the Japanese government’s goal of strengthening education on renewable energy to promote ZEH

MOESM1 of Tracking the PM2.5 inventories embodied in the trade among China, Japan and Korea

Additional file 1. Integration of sectors from date source GAINS and WIOD

Perceived feasibility and potential barriers of a net-zero system transition among Japanese experts

Abstract Many governments and non-state actors have pledged to achieve net-zero greenhouse gas emissions, raising questions about the feasibility of these decarbonization goals. The existing literature, however, mostly relied on technoeconomic assessments and lack broad contextual considerations such as national conditions and local sociocultural characteristics. Here, we present a framework for assessing perceived feasibility and multi-dimensional barriers for net-zero transition that can complement existing methods of technoeconomic traditions. We applied this framework to the Japanese net-zero goal by surveying more than 100 experts from diverse fields with a shared national context. Most of the experts supported the desirability of the net-zero goal and chose a probability of 33–66% for its feasibility. However, the distribution of feasibility assessments differs between groups of integrated assessment modelers and the Intergovernmental Panel on Climate Change authors and other researchers, suggesting opportunities for further exploration within and between communities. Identified barriers reflect a unique national condition of Japan and include the limitations of national strategies and clean energy supply. The present framework can be extended to non-experts, data-scarce geographies and sectors

Recycling Potential of Plastic Resources from End-of-Life Passenger Vehicles in China

A rapid increase in the number of end-of-life (EoL) passenger vehicles has led to a large amount of waste plastics in China. However, the scale and efficiency of recycling resources from EoL vehicles still restricts the sustainable and healthy development of the automotive industry. The current behavior of automotive/recycling industry entities, as well as the strategy of waste management policymakers, may depend on the potential of total recyclable resources. To reveal such recycling potential of various plastic materials in EoL passenger vehicles, we predicted total EoL passenger vehicles in China from 2021 to 2030 (used the Weibull distribution) considering passenger vehicle ownership (estimated by the Gompertz model), quantified the demand for new passenger vehicles (estimated using its non-linear relationship with income level and passenger vehicle ownership), and assessed the recyclable plastics by categories and by provinces. The results show that (i) the annual average recycled plastic resources from EoL vehicles would exceed 2400 thousand t in 2030, more than 2.5 times in 2021, showing a great recycling potential; (ii) the differences among the three scenarios are relatively small, indicating that no matter the saturation level of passenger vehicles in China would be high or low, a rapid increase of recyclable plastic resources can be expected from 2021 to 2030; (iii) at the provincial level, a considerable gap between the potential of recycling plastic from EoL passenger vehicles and the regional processing capacity. Given such great potential and regional differences, the recycling policies should be applied in stages and consider the development level and recovery pressure in each region

Study on the Effect of Surface Properties of Non-Metallic Materials on the Growth Mechanism of Crystallization Fouling

In order to alleviate the serious problem of scaling in oilfield water injection pipelines, we developed a scale collection device and applied it in the field based on the idea to “change passive descaling to active descaling”, but the effect is not stable, so we need to improve the descaling effect. Firstly, this paper analyzed the effect of surface physical properties of eight non-metallic materials on CaCO3 scale growth and their mechanisms through shear experiments. Then, the influence of surface properties (roughness, contact angle, surface energy) on the scale growth characteristics was investigated. Finally, the influence of material surface properties on the friction coefficient was studied by a cyclic experiment. The results showed that except for PTFE (polytetrafluoroethylene), the fouling amount of the other seven materials changed abruptly at 18 h, and the maximum fouling amount of FRP was 2.05 g/m3. It was found by scanning electron microscopy that the fouling particles on the surface of FRP were interconnected and presented in the form of flakes, which was related to the larger surface wettability, surface energy, and roughness. At the same time, the surface properties of the material have a certain relationship with the friction coefficient, and the influence of the contact angle on the friction coefficient is greater than the surface energy and roughness

The Potential and Trend of End-Of-Life Passenger Vehicles Recycling in China

The contradiction between limited resources and rapid development in the automobile industry has been driving society to seek the supply of recyclable resources from End-of-Life Vehicles (ELVs). It has become an urgent need for vehicle recycling policymakers to have an overall understanding of the end-of-life (EoL) vehicle population, as well as for vehicle producers to note what and how they can benefit from ELV recycling. This paper estimated the potential population of EoL passenger vehicles, all recyclable resources from them, as well as the economic values of these recyclable resources. The results show that in 2030, with a lighter-weight trend of passenger vehicles, more than 26.3 million passenger vehicles will be retired with 19.1 million tons of recyclable steel and 6.2 million tons of plastics. The theoretical economic value of all recyclable resources will reach 101.3 billion yuan ($14.4 billion) in 2030, which is an average of approximately 2.4 thousand yuan ($341.8) for each EoL passenger vehicle. It is time for the vehicle producers to shift to a manufacturing mode considering such large potential of ELV recycling. The scenario analysis suggests that in the context of a light-weighting trend, ELV resource recovery in the future calls for improvement in the recycling and reuse technologies of plastics and rubbers