FARM AND TRADE PROSPECTS FOR 2000

International Relations/Trade,

The Philistines

The purpose of this study is to review the history of the Philistines, special emphasis being placed on their relation and influence on Israel

1959 Ruby Yearbook

A digitized copy of the 1959 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1062/thumbnail.jp

Topics in Quantum Computers

I provide an introduction to quantum computers, describing how they might be realized using language accessible to a solid state physicist. A listing of the minimal requirements for creating a quantum computer is given. I also discuss several recent developments in the area of quantum error correction, a subject of importance not only to quantum computation, but also to some aspects of the foundations of quantum theory.Comment: 22 pages, Latex, 1 eps figure, Paper to be published in "Mesoscopic Electron Transport", edited by L. Kowenhoven, G. Schoen and L. Sohn, NATO ASI Series E, Kluwer Ac. Publ., Dordrecht. v2: typos in refrences fixe

Prospectus, October 24, 1979

SURVEY MAKES WAVES; The Week in Review: Across the globe, In the nation, Throughout the state, Around the town, Etc….; Briefs: College to host math contest, Parkland Players present \u27Dracula\u27, Summary of board listed, Champaign council approves bonds, Women\u27s program seeks young blood, Monticello council to discuss tax rate, Program on strokes to be presented, Arthritis program to be presented, Future educators program tomorrow, Nutritionm health, disease are topics, Store celebrates 1st; Letter to editor: Dean congratulates foreigners; Weekly Calendar; Area high schools to visit campus; S.T.O. raffle winners are announced; Give a little blood, then see blood; Women at Home on Tuesday; Editorial: Censorship at WPCD?; PATH raises grievances; Pumpkins and costumes in contest next week; Lincoln Square has art show; Oktoberfest today: a taste of German; Reviews: Ending to the beat has better taste, B-52s: a glimpse of future and past; Classifieds; Music club has enthusiasm; Athletic and rec fields near completion; V-ball gains momentum; Golf team advances to state; Elam blows off competition: harriers 3rd; PC hosts golf, gets 2nd; Fast Freddy loses again; Fast Freddy Contesthttps://spark.parkland.edu/prospectus_1979/1007/thumbnail.jp

Prospectus, October 17, 1979

CANTEEN STILL IN TROUBLE; Language: Big adjustment; Across the globe; In the nation; Throughout the state; Around the town; Fire guts Athenaeum; Briefs: \u27Living Newspaper\u27 performs Oct. 23, German foods, Seniors to visit, Costumes display, Apply no more, Ciricle K events, Krannert events; Letter to editor: Ohio inmate wants pen-pal; Field trips to view artwork; French cooking offered Weds.; I.O.E. to evaluate Parkland College Oct. 30; Everyone would like a Vette; Feature: Fast Freddie wows women; Reviews: \u27Long Run\u27 ran, Science fiction and yesteryear unite in \u27time after time\u27, STYX book-album; Jumping out of a plane -- FOR FUN; Classifieds; Concerts: Frampton -- yea, Simms -- nay, Kenny Loggins storms C-U; Cross Country running well; Outlaws are a crowd pleaser; Sports: Cobras win 4 more; Superman Fast Freddy did it again? 4-9; Freddy\u27s picks; Fast Freddy Contest; Intramural Standingshttps://spark.parkland.edu/prospectus_1979/1008/thumbnail.jp

Proportions of Convective and Stratiform Precipitation Revealed in Water Isotope Ratios

Tropical and midlatitude precipitation is fundamentally of two types, spatially-limited and high-intensity convective or widespread and lower-intensity stratiform, owing to differences in vertical air motions and microphysical processes governing rain formation. These processes are difficult to observe or model and precipitation partitioning into rain types is critical for understanding how the water cycle responds to climate changes. Here, we combine two independent data sets – convective and stratiform precipitation fractions, derived from the Tropical Rainfall Measuring Mission satellite or synoptic cloud observations, and stable isotope and tritium compositions of surface precipitation, derived from a global network – to show that isotope ratios reflect rain type proportions and are negatively correlated with stratiform fractions. Condensation and riming associated with boundary layer moisture produces higher isotope ratios in convective rain, along with higher tritium when riming in deep convection occurs with entrained air at higher altitudes. Based on our data, stable isotope ratios can be used to monitor changes in the character of precipitation in response to periodic variability or changes in climate. Our results also provide observational constraints for an improved simulation of convection in climate models and a better understanding of isotope variations in proxy archives, such as speleothems and tropical ice

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

The advent of Adcetris™ and Kadcyla™, two recently FDA-approved antibody-drug conjugates (ADCs), in the clinic has had a major impact on the treatment of lymphoma and breast cancer patients, respectively, worldwide. Despite these successes many new ADCs fail at various stages of development, often due to shortcomings in the methods used for their assembly. To address this problem we have developed next generation maleimides (NGMs), which specifically re-bridge reduced interchain disulfide bonds and allow the efficient conjugation of small molecules to antibodies, without the need for engineering of the target antibody. The method is site-specific and generates near homogeneous products in good yields. Moreover, adjustment of the reaction conditions allows control of the conjugation in terms of stoichiometry (drug-loading) and site selectivity. Using this method we prepared a series of ADCs from trastuzumab and doxorubicin (DOX) with a controlled drug-to-antibody ratio (DAR) of 1, 2, 3 and 4. All of these constructs were fully active by ELISA and had more than 90% of re-bridged disulfide bonds by CE-SDS when compared to clinical grade antibody. Furthermore, digest experiments of the DAR 2 material revealed that almost all of the drug had been targeted to the Fab arms of the antibody. Thus, NGMs offer a flexible and simple platform for the controlled assembly of ADCs from an antibody

Global analyses of TetR family transcriptional regulators in mycobacteria indicates conservation across species and diversity in regulated functions

BACKGROUND: Mycobacteria inhabit diverse niches and display high metabolic versatility. They can colonise both humans and animals and are also able to survive in the environment. In order to succeed, response to environmental cues via transcriptional regulation is required. In this study we focused on the TetR family of transcriptional regulators (TFTRs) in mycobacteria. RESULTS: We used InterPro to classify the entire complement of transcriptional regulators in 10 mycobacterial species and these analyses showed that TFTRs are the most abundant family of regulators in all species. We identified those TFTRs that are conserved across all species analysed and those that are unique to the pathogens included in the analysis. We examined genomic contexts of 663 of the conserved TFTRs and observed that the majority of TFTRs are separated by 200 bp or less from divergently oriented genes. Analyses of divergent genes indicated that the TFTRs control diverse biochemical functions not limited to efflux pumps. TFTRs typically bind to palindromic motifs and we identified 11 highly significant novel motifs in the upstream regions of divergently oriented TFTRs. The C-terminal ligand binding domain from the TFTR complement in M. tuberculosis showed great diversity in amino acid sequence but with an overall architecture common to other TFTRs. CONCLUSION: This study suggests that mycobacteria depend on TFTRs for the transcriptional control of a number of metabolic functions yet the physiological role of the majority of these regulators remain unknown. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1696-9) contains supplementary material, which is available to authorized users