273 research outputs found
BioWorkbench: A High-Performance Framework for Managing and Analyzing Bioinformatics Experiments
Advances in sequencing techniques have led to exponential growth in
biological data, demanding the development of large-scale bioinformatics
experiments. Because these experiments are computation- and data-intensive,
they require high-performance computing (HPC) techniques and can benefit from
specialized technologies such as Scientific Workflow Management Systems (SWfMS)
and databases. In this work, we present BioWorkbench, a framework for managing
and analyzing bioinformatics experiments. This framework automatically collects
provenance data, including both performance data from workflow execution and
data from the scientific domain of the workflow application. Provenance data
can be analyzed through a web application that abstracts a set of queries to
the provenance database, simplifying access to provenance information. We
evaluate BioWorkbench using three case studies: SwiftPhylo, a phylogenetic tree
assembly workflow; SwiftGECKO, a comparative genomics workflow; and RASflow, a
RASopathy analysis workflow. We analyze each workflow from both computational
and scientific domain perspectives, by using queries to a provenance and
annotation database. Some of these queries are available as a pre-built feature
of the BioWorkbench web application. Through the provenance data, we show that
the framework is scalable and achieves high-performance, reducing up to 98% of
the case studies execution time. We also show how the application of machine
learning techniques can enrich the analysis process
Quantum Computing in Molecular Magnets
Shor and Grover demonstrated that a quantum computer can outperform any
classical computer in factoring numbers and in searching a database by
exploiting the parallelism of quantum mechanics. Whereas Shor's algorithm
requires both superposition and entanglement of a many-particle system, the
superposition of single-particle quantum states is sufficient for Grover's
algorithm. Recently, the latter has been successfully implemented using Rydberg
atoms. Here we propose an implementation of Grover's algorithm that uses
molecular magnets, which are solid-state systems with a large spin; their spin
eigenstates make them natural candidates for single-particle systems. We show
theoretically that molecular magnets can be used to build dense and efficient
memory devices based on the Grover algorithm. In particular, one single crystal
can serve as a storage unit of a dynamic random access memory device. Fast
electron spin resonance pulses can be used to decode and read out stored
numbers of up to 10^5, with access times as short as 10^{-10} seconds. We show
that our proposal should be feasible using the molecular magnets Fe8 and Mn12.Comment: 13 pages, 2 figures, PDF, version published in Nature, typos
correcte
Spin qubits with electrically gated polyoxometalate molecules
Spin qubits offer one of the most promising routes to the implementation of
quantum computers. Very recent results in semiconductor quantum dots show that
electrically-controlled gating schemes are particularly well-suited for the
realization of a universal set of quantum logical gates. Scalability to a
larger number of qubits, however, remains an issue for such semiconductor
quantum dots. In contrast, a chemical bottom-up approach allows one to produce
identical units in which localized spins represent the qubits. Molecular
magnetism has produced a wide range of systems with tailored properties, but
molecules permitting electrical gating have been lacking. Here we propose to
use the polyoxometalate [PMo12O40(VO)2]q-, where two localized spins-1/2 can be
coupled through the electrons of the central core. Via electrical manipulation
of the molecular redox potential, the charge of the core can be changed. With
this setup, two-qubit gates and qubit readout can be implemented.Comment: 9 pages, 6 figures, to appear in Nature Nanotechnolog
Quiet SDS Josephson Junctions for Quantum Computing
Unconventional superconductors exhibit an order parameter symmetry lower than
the symmetry of the underlying crystal lattice. Recent phase sensitive
experiments on YBCO single crystals have established the d-wave nature of the
cuprate materials, thus identifying unambiguously the first unconventional
superconductor. The sign change in the order parameter can be exploited to
construct a new type of s-wave - d-wave - s-wave Josephson junction exhibiting
a degenerate ground state and a double-periodic current-phase characteristic.
Here we discuss how to make use of these special junction characteristics in
the construction of a quantum computer. Combining such junctions together with
a usual s-wave link into a SQUID loop we obtain what we call a `quiet' qubit
--- a solid state implementation of a quantum bit which remains optimally
isolated from its environment.Comment: 4 pages, 2 ps-figure
Quantum Nucleation in a Ferromagnetic Film Placed in a Magnetic Field at an Arbitrary Angle
We study the quantum nucleation in a thin ferromagnetic film placed in a
magnetic field at an arbitrary angle. The dependence of the quantum nucleation
and the temperature of the crossover from thermal to quantum regime on the
direction and the strength of the applied field are presented. It is found that
the maximal value of the rate and that of the crossover temperature are
obtained at a some angle with the magnetic field, not in the direction of the
applied field opposite to the initial easy axis.Comment: 15 pages, RevTex, 3 PostScript figures. To appear in Phys. Rev.
Topologically protected quantum bits from Josephson junction arrays
All physical implementations of quantum bits (qubits), carrying the
information and computation in a putative quantum computer, have to meet the
conflicting requirements of environmental decoupling while remaining
manipulable through designed external signals. Proposals based on quantum
optics naturally emphasize the aspect of optimal isolation, while those
following the solid state route exploit the variability and scalability of
modern nanoscale fabrication techniques. Recently, various designs using
superconducting structures have been successfully tested for quantum coherent
operation, however, the ultimate goal of reaching coherent evolution over
thousands of elementary operations remains a formidable task. Protecting qubits
from decoherence by exploiting topological stability, a qualitatively new
proposal due to Kitaev, holds the promise for long decoherence times, but its
practical physical implementation has remained unclear so far. Here, we show
how strongly correlated systems developing an isolated two-fold degenerate
quantum dimer liquid groundstate can be used in the construction of
topologically stable qubits and discuss their implementation using Josephson
junction arrays.Comment: 6 pages, 4 figure
Bloch oscillations of magnetic solitons in anisotropic spin-1/2 chains
We study the quantum dynamics of soliton-like domain walls in anisotropic
spin-1/2 chains in the presence of magnetic fields. In the absence of fields,
domain walls form a Bloch band of delocalized quantum states while a static
field applied along the easy axis localizes them into Wannier wave packets and
causes them to execute Bloch oscillations, i.e. the domain walls oscillate
along the chain with a finite Bloch frequency and amplitude. In the presence of
the field, the Bloch band, with a continuum of extended states, breaks up into
the Wannier-Zeeman ladder -- a discrete set of equally spaced energy levels. We
calculate the dynamical structure factor in the one-soliton sector at finite
frequency, wave vector, and temperature, and find sharp peaks at frequencies
which are integer multiples of the Bloch frequency. We further calculate the
uniform magnetic susceptibility and find that it too exhibits peaks at the
Bloch frequency. We identify several candidate materials where these Bloch
oscillations should be observable, for example, via neutron scattering
measurements. For the particular compound CoCl_2.2H_2O we estimate the Bloch
amplitude to be on the order of a few lattice constants, and the Bloch
frequency on the order of 100 GHz for magnetic fields in the Tesla range and at
temperatures of about 18 Kelvin.Comment: 31 single-spaced REVTeX pages, including 7 figures embedded with eps
Semiclassical mechanics of a non-integrable spin cluster
We study detailed classical-quantum correspondence for a cluster system of
three spins with single-axis anisotropic exchange coupling. With autoregressive
spectral estimation, we find oscillating terms in the quantum density of states
caused by classical periodic orbits: in the slowly varying part of the density
of states we see signs of nontrivial topology changes happening to the energy
surface as the energy is varied. Also, we can explain the hierarchy of quantum
energy levels near the ferromagnetic and antiferromagnetic states with EKB
quantization to explain large structures and tunneling to explain small
structures.Comment: 9 pages. For related works see
"http://www.msc.cornell.edu/~clh/clh.html
Evaluation of adrenal tumors by magnetic resonance imaging with histological correlation
A ressonância magnética é ferramenta importante para a detecção e caracterização dos tumores adrenais. O conhecimento das diferentes apresentações dos tumores primários e secundários à ressonância magnética e sua correlação com dados da histologia são essenciais para o correto raciocínio diagnóstico. Este artigo revisa os aspectos que podem estreitar o diagnóstico diferencial dos tumores adrenais, dando ênfase à correlação histológica daqueles mais comuns.Magnetic resonance imaging is an important tool for the detection and characterization of adrenal tumors. The knowledge about the different presentations of primary and secondary adrenal tumors at magnetic resonance imaging and their correlation with histological data are essential for the establishment of a correct diagnosis. The present study reviews magnetic resonance imaging aspects which may narrow the differential diagnosis of adrenal tumors, emphasizing the histological correlation of the most frequent ones
Tunable few-electron double quantum dots and Klein tunnelling in ultra-clean carbon nanotubes
Quantum dots defined in carbon nanotubes are a platform for both basic
scientific studies and research into new device applications. In particular,
they have unique properties that make them attractive for studying the coherent
properties of single electron spins. To perform such experiments it is
necessary to confine a single electron in a quantum dot with highly tunable
barriers, but disorder has until now prevented tunable nanotube-based
quantum-dot devices from reaching the single-electron regime. Here, we use
local gate voltages applied to an ultra-clean suspended nanotube to confine a
single electron in both a single quantum dot and, for the first time, in a
tunable double quantum dot. This tunability is limited by a novel type of
tunnelling that is analogous to that in the Klein paradox of relativistic
quantum mechanics.Comment: 21 pages including supplementary informatio
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