189 research outputs found

    Entrepreneurship In The Republic Of Uzbekistan: A Model For Other Emerging Nations

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    On August 31, 1991, the Republic of Uzbekistan proclaimed its independence as a free nation. As a part of the former U.S.S.R., the Uzbekistan people were required to adhere to the mandates of the Central Government in the production of manufactured goods, agricultural commodities and other goods and services. The Republic has consistently been one of the top five cotton producing countries in the world, and its economy is largely dependent on this commodity. On March 2, 1992, the Republic was admitted as a member of the United Nations and adopted its first constitution on December 8, 1992. As the Republic completes its conversion into a truly democratic nation, its leaders have taken a strong and determined stance toward fostering entrepreneurship and economic reform, privatizing business, efficiently utilizing the land base, and reversing environmental damage to the ecology of adversely affected regions. Simultaneously, government leaders took affirmative steps to maintain cotton production in order to stabilize land use policies and finance economic reform. A significant portion of governmental efforts over the last ten years have focused on encouraging free enterprise and entrepreneurship through directives which return business decision-making to entrepreneurs and business leaders. These business decisions were previously made by the Central Government which dictated production output based upon perceived needs of the former U.S.S.R. This paper will explore how the government of Uzbekistan has promoted and nurtured a spirit of entrepreneurship among its people through policies which foster free entrepreneurial thought, build viable business entities, equitably transfer public lands to private use, and reform the economy. The leaders of this emerging nation have carefully and wisely chosen the path of free enterprise which has created an ideal environment for entrepreneurship. Their efforts have succeeded in building a nation which grows more prosperous each year. The Republic of Uzbekistan is truly a nation which should serve as a model for other emerging nations of the world

    Substantial Notice Under the Digital Millennium Copyright Act

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    This Article addresses the requirements of substantial notification under the DMCA. First, the Article will present an overview of Title II of the DMCA. Second, the Article will review the facts of ALS Scan, Inc. v. RemarQ Communities, Inc. and present the issue and its importance. Third, the Article will analyze the district court\u27s and court of appeals\u27s holdings and evaluate the significance of this case in the e-commerce legal landscape. Finally, the Article will present its conclusions

    An Apparatus for Varying Effective Dihedral in Flight with Application to a Study of Tolerable Dihedral on a Conventional Fighter Airplane

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    An apparatus for varying effective dihedral in flight by means of servo actuation of the ailerons in response to sideslip angle is described. The results of brief flight tests of the apparatus on a conventional fighter airplane are presented and discussed. The apparatus is shown to have satisfactory simulated a wide range of effective dihedral under static and dynamic conditions. The effects of a small amount of servo lag are shown to be measurable when the apparatus is simulating small negative values of dihedral. However, these effects were not considered by the pilots to give the airplane an artificial feel. The results of an investigation employing the apparatus to determine the tolerable (safe for normal fighter operation) range of effective dihedral on the test airplane are presented

    Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

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    Dysregulation of brain iron metabolism is one of the pathological features of aging and Alzheimer’s disease (AD), a neurodegenerative disease characterized by progressive memory loss and cognitive impairment. While physical inactivity is one of the risk factors for AD and regular exercise improves cognitive function and reduces pathology associated with AD, the underlying mechanisms remain unclear. The purpose of the study is to explore the effect of regular physical exercise on modulation of iron homeostasis in the brain and periphery of the 5xFAD mouse model of AD. By using inductively coupled plasma mass spectrometry and a variety of biochemical techniques, we measured total iron content and level of proteins essential in iron homeostasis in the brain and skeletal muscles of sedentary and exercised mice. Long-term voluntary running induced redistribution of iron resulted in altered iron metabolism and trafficking in the brain and increased iron content in skeletal muscle. Exercise reduced levels of cortical hepcidin, a key regulator of iron homeostasis, coupled with interleukin-6 (IL-6) decrease in cortex and plasma. We propose that regular exercise induces a reduction of hepcidin in the brain, possibly via the IL-6/STAT3/JAK1 pathway. These findings indicate that regular exercise modulates iron homeostasis in both wild-type and AD mice
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