Natural history and outcome in systemic AA amyloidosis

BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders. Little is known about the natural history of AA amyloidosis or its response to treatment.METHODS:We evaluated clinical features, organ function, and survival among 374 patients with AA amyloidosis who were followed for a median of 86 months. The SAA concentration was measured serially, and the amyloid burden was estimated with the use of whole-body serum amyloid P component scintigraphy. Therapy for inflammatory diseases was administered to suppress the production of SAA.RESULTS:Median survival after diagnosis was 133 months; renal dysfunction was the predominant disease manifestation. Mortality, amyloid burden, and renal prognosis all significantly correlated with the SAA concentration during follow-up. The risk of death was 17.7 times as high among patients with SAA concentrations in the highest eighth, or octile, (greater/equal 155 mg per liter) as among those with concentrations in the lowest octile (< 4 mg per liter); and the risk of death was four times as high in the next-to-lowest octile (4 to 9 mg per liter). The median SAA concentration during follow-up was 6 mg per liter in patients in whom renal function improved and 28 mg per liter in those in whom it deteriorated (P < 0.001). Amyloid deposits regressed in 60% of patients who had a median SAA concentration of less than 10 mg per liter, and survival among these patients was superior to survival among those in whom amyloid deposits did not regress (P=0.04).CONCLUSIONS:The effects of renal dysfunction dominate the course of AA amyloidosis, which is associated with a relatively favorable outcome in patients with SAA concentrations that remain in the low-normal range (< 4 mg per liter)

COVID-19 and Nevada Counties: Employment Data, May 2019 and May 2021

This fact sheet displays county-level employment data and unemployment rates for 17 counties in Nevada, as reported by The Daily Yonder article “Rural Employment Grew in May, but Fewer People Are Seeking Jobs” in July 2021. Bill Bishop and Tim Marema compiled data from the U.S. Bureau of Labor Statistics (BLS) for each county in the United States for May 2019 and May 2021

Public University and College Enrollment in the Mountain West, 2019-2021

On June 10, 2021, the National Student Clearinghouse Research Center released the Spring 2021 Current Term Enrollment Estimates (CTTE) report. The report provides estimated postsecondary enrollment numbers based on the Clearinghouse universe of institutions. The impact of COVID-19 related disruptions has caused higher education enrollment to fall to what the National Student Clearinghouse suggests are “new lows.” This fact sheet explores trends in higher education enrollment at Mountain West colleges during the 2020 and 2021 Spring semesters

2014-2019 National Science Foundation (NSF) Rankings by Total R&D Expenditures

This fact sheet presents National Science Foundation (NSF) funding data for 10 individual research universities in addition to the combined funding received by the University of Nevada, Las Vegas (UNLV) and the University of Nevada, Reno (UNR) for the years 2014 to 2019

American Rescue Plan Act (ARPA): City and County Budget Allocations in the Mountain West

This fact sheet details how city and county governments within the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah allocated funds from the State and Local Fiscal Recovery Fund (SLFRF) portion of the American Rescue Plan Act (ARPA). Brookings Metro in partnership with the National League of Cities and the National Association of Counties created the “Local Government ARPA Investment Tracker” to display how communities across the country allocate this financial resource. This interactive site allows budget information from cities and counties to be added as such decisions are made

The Desert Southwest: Population Growth 2010-2020

In 2021 the United States Census Bureau identified the Desert Southwest as one of the fastest growing regions in the country. The Desert Southwest encompasses portions of five states (Arizona, California, Nevada, New Mexico, and Texas) including forty counties and ten metropolitan statistical areas (MSAs). Using data from the Census Bureau, this fact sheet showcases population growth within Desert Southwest counties and metropolitan statistical areas from 2010 to 2020

Investment Patterns in Mountain West States, Counties, and Nevada Cities 2005-2019

The purpose of this fact sheet is to summarize findings on capital flows across Mountain West states and counties, and within Nevada cities. The “Gauging Investment Patterns across the US” report by the Urban Institute present findings of overall volume of capital deployed, racial equity of investments, and income equity for each respective geographic area. The full report further breaks down these three main categories into 18 other metrics

2020 Most Dynamic Micropolitans in the Mountain West

This fact sheet draws from the “Most Dynamic Micropolitans 2020” report released by Heartland Forward, “an institute for economic renewal […] with a mission to improve economic performance in the center of the United States.” In this report, Heartland Forward offers the Most Dynamic Micropolitan Index to analyze the economies of smaller communities for a total of 515 micropolitan areas nationally. This fact sheet includes information on job growth, annual pay growth, and personal income growth for micropolitan areas in the Mountain West region

Nevada Medical Residencies, 2021-2022

This fact sheet highlights medical residency data for the 2021 and 2022 graduating classes of the Kirk Kerkorian School of Medicine at the University of Nevada, Las Vegas (UNLV) and the University of Nevada, Reno (UNR) School of Medicine. This fact sheet highlights the number of residency program matches at the Kirk Kerkorian School of Medicine at UNLV and the UNR School of Medicine in 2021 and 2022 and reveals where Nevada medical school students pursue their residencies

House Price Changes in the Mountain West, 1991-2020

This fact sheet measures the average price change in single-family house prices in Mountain West states and metropolitan areas. This fact sheet utilizes data from the Federal Housing Finance Agency\u27s (FHFA) House Price Index (HPI) tool to show quarterly and yearly trends as far back as 1991 to 2020