Development and Implementation of an Isentropic Potential Vorticity Algorithm for use at Air Force Global Weather Center

This thesis presents and validates methods for calculating isentropic potential vorticity (IPV) and applies these methods in software programs planned for implementation at the Air Force Global Weather Center (AFGWC). The IPV programs will provide Air Force Weather forecasters additional tools to diagnose atmospheric kinematics and understand atmospheric dynamics. A FORTRAN program is recommended using mandatory-level isobaric data projected to be available on AFGWC computer systems, specifically, from the Navy Operational Global Atmosphere Prediction System and Medium Range Forecast models. Program development and analysis consists of three main steps: (1) data retrieval; (2) IPV calculations; and, (3) interpolation to an isentropic vertical coordinate system. This thesis recommends performing IPV calculations at constant pressure for comparison with other mandatory-level isobaric parameters, or in routine cross-sectional analysis. Additionally, a recommendation is made to calculate IPV at constant potential temperature from interpolated isentropic state variables instead of interpolating isobaric IPV fields. Applications of the developed programs include visualization of synoptic-scale motions an alternative method of locating the tropopause in cross-sectional analysis. This thesis is a significant effort to move toward operational use of isentropic analysis and the incorporation of IPV analysis into forecasting techniques at AFGWC

High School Achievement in Maine: Where You Come From Matters More Than School Size and Expenditures

Fern Desjardins and Gordon Donaldson report on their research examining the relationship between academic achievement in Maine’s public high schools and school size, per-pupil operating costs, and socioeconomic status. Using aggregated Maine Educational Assessment (MEA) scores, their study confirmed previous research that socioeconomic status (using both family and community measures) is the most important factor associated with achievement, while school size is not a critical factor. Additionally, the authors found that per-pupil operating costs are higher in the state’s largest and smallest high schools. The authors suggest that the creation of larger districts and larger schools, as supported by recent state policies, will not necessarily mitigate inequities in student achievement resulting from family and community socioeconomic status, and may not yield the desired cost savings

The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation

The lysis of infected cells by disease-causing microorganisms is an efficient but risky strategy for disseminated infection, as it exposes the pathogen to the full repertoire of the host's immune system. Cryptococcus neoformans is a widespread fungal pathogen that causes a fatal meningitis in HIV and other immunocompromised patients. Following intracellular growth, cryptococci are able to escape their host cells by a non-lytic expulsive mechanism that may contribute to the invasion of the central nervous system. Non-lytic escape is also exhibited by some bacterial pathogens and is likely to facilitate long-term avoidance of the host immune system during latency. Here we show that phagosomes containing intracellular cryptococci undergo repeated cycles of actin polymerisation. These actin ‘flashes’ occur in both murine and human macrophages and are dependent on classical WASP-Arp2/3 complex mediated actin filament nucleation. Three dimensional confocal imaging time lapse revealed that such flashes are highly dynamic actin cages that form around the phagosome. Using fluorescent dextran as a phagosome membrane integrity probe, we find that the non-lytic expulsion of Cryptococcus occurs through fusion of the phagosome and plasma membranes and that, prior to expulsion, 95% of phagosomes become permeabilised, an event that is immediately followed by an actin flash. By using pharmacological agents to modulate both actin dynamics and upstream signalling events, we show that flash occurrence is inversely related to cryptococcal expulsion, suggesting that flashes may act to temporarily inhibit expulsion from infected phagocytes. In conclusion, our data reveal the existence of a novel actin-dependent process on phagosomes containing cryptococci that acts as a potential block to expulsion of Cryptococcus and may have significant implications for the dissemination of, and CNS invasion by, this organism.\ud \u

Le FORUM, Vol. 34 No. 3

https://digitalcommons.library.umaine.edu/francoamericain_forum/1027/thumbnail.jp

Le FORUM, Vol. 36 No. 3

https://digitalcommons.library.umaine.edu/francoamericain_forum/1034/thumbnail.jp

Le FORUM, Vol. 35 No. 4

https://digitalcommons.library.umaine.edu/francoamericain_forum/1032/thumbnail.jp

Le FORUM, Vol. 37 No. 1

https://digitalcommons.library.umaine.edu/francoamericain_forum/1036/thumbnail.jp

Le FORUM, Vol. 34 No. 4

https://digitalcommons.library.umaine.edu/francoamericain_forum/1028/thumbnail.jp

Atypical audiovisual speech integration in infants at risk for autism

The language difficulties often seen in individuals with autism might stem from an inability to integrate audiovisual information, a skill important for language development. We investigated whether 9-month-old siblings of older children with autism, who are at an increased risk of developing autism, are able to integrate audiovisual speech cues. We used an eye-tracker to record where infants looked when shown a screen displaying two faces of the same model, where one face is articulating/ba/and the other/ga/, with one face congruent with the syllable sound being presented simultaneously, the other face incongruent. This method was successful in showing that infants at low risk can integrate audiovisual speech: they looked for the same amount of time at the mouths in both the fusible visual/ga/− audio/ba/and the congruent visual/ba/− audio/ba/displays, indicating that the auditory and visual streams fuse into a McGurk-type of syllabic percept in the incongruent condition. It also showed that low-risk infants could perceive a mismatch between auditory and visual cues: they looked longer at the mouth in the mismatched, non-fusible visual/ba/− audio/ga/display compared with the congruent visual/ga/− audio/ga/display, demonstrating that they perceive an uncommon, and therefore interesting, speech-like percept when looking at the incongruent mouth (repeated ANOVA: displays x fusion/mismatch conditions interaction: F(1,16) = 17.153, p = 0.001). The looking behaviour of high-risk infants did not differ according to the type of display, suggesting difficulties in matching auditory and visual information (repeated ANOVA, displays x conditions interaction: F(1,25) = 0.09, p = 0.767), in contrast to low-risk infants (repeated ANOVA: displays x conditions x low/high-risk groups interaction: F(1,41) = 4.466, p = 0.041). In some cases this reduced ability might lead to the poor communication skills characteristic of autism

Comparing etoricoxib and celecoxib for preemptive analgesia for acute postoperative pain in patients undergoing arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>The efficacy of selective cox-2 inhibitors in postoperative pain reduction were usually compared with conventional non-selective conventional NSAIDs or other types of medicine. Previous studies also used selective cox-2 inhibitors as single postoperative dose, in continued mode, or in combination with other modalities. The purpose of this study was to compare analgesic efficacy of single preoperative administration of etoricoxib versus celecoxib for post-operative pain relief after arthroscopic anterior cruciate ligament reconstruction.</p> <p>Methods</p> <p>One hundred and two patients diagnosed as anterior cruciate ligament injury were randomized into 3 groups using opaque envelope. Both patients and surgeon were blinded to the allocation. All of the patients were operated by one orthopaedic surgeon under regional anesthesia. Each group was given either etoricoxib 120 mg., celecoxib 400 mg., or placebo 1 hour prior to operative incision. Post-operative pain intensity, time to first dose of analgesic requirement and numbers of analgesic used for pain control and adverse events were recorded periodically to 48 hours after surgery. We analyzed the data according to intention to treat principle.</p> <p>Results</p> <p>Among 102 patients, 35 were in etoricoxib, 35 in celecoxib and 32 in placebo group. The mean age of the patients was 30 years and most of the injury came from sports injury. There were no significant differences in all demographic characteristics among groups. The etoricoxib group had significantly less pain intensity than the other two groups at recovery room and up to 8 hours period but no significance difference in all other evaluation point, while celecoxib showed no significantly difference from placebo at any time points. The time to first dose of analgesic medication, amount of analgesic used, patient's satisfaction with pain control and incidence of adverse events were also no significantly difference among three groups.</p> <p>Conclusions</p> <p>Etoricoxib is more effective than celecoxib and placebo for using as preemptive analgesia for acute postoperative pain control in patients underwent arthroscopic anterior cruciate ligament reconstruction.</p> <p>Trial registration number</p> <p>NCT01017380</p