9 research outputs found
Using technology to improve access to specialist care in amyotrophic lateral sclerosis: A systematic review
Our objective was to review the evidence for using technology to improve access to specialist care for patients with amyotrophic lateral sclerosis (ALS) and their carers.
Medline, Google Scholar and the Cochrane library were searched for articles describing technology that enabled clinical care of patients with ALS or their carers where the patient/carer and clinician were not in the same location. Two applications were identified: telemedicine to facilitate video conferencing as an alternative to outpatient consultations and telehealth monitoring for patients with respiratory failure. One randomized controlled trial using telehealth in patients with respiratory failure including 22 patients with ALS was identified. While rates of hospitalization were reduced, overall mortality was unchanged and there were too few patients with ALS in the study to detect significant benefit. In conclusion, there is limited evidence to support the use of telemedicine or telehealth in the care of patients with ALS. Future research needs to develop an understanding of the key beneficial aspects of the traditional specialist ALS service and how these factors could be delivered using technology. Successful evaluation and implementation of technologies to facilitate access to specialist care will only be possible if all the relevant impacts of an intervention are understood and measured
Mortalidade infantil em Cuiabá, Mato Grosso, Brasil, 2005: comparação entre o cálculo direto e após o linkage entre bancos de dados de nascidos vivos e óbitos infantis
Confiabilidade da Declaração de Nascido Vivo como fonte de informação sobre os defeitos congĂŞnitos no MunicĂpio de SĂŁo Carlos, SĂŁo Paulo, Brasil
Nonneuronal cholinergic system in human erythrocytes : biological role and cinical relevance
The original publication is available at www.springerlink.com© Springer Science+Business Media, LLC 2010Acetylcholine is well known in the medical
setting as one of the most exemplary neurotransmitters. Its ubiquity in nature otherwise suggests a theoretically
diverse spectrum of action and an extremely early appearance in the evolutionary process. In humans, acetylcholine
and its synthesizing enzyme, choline acetyltransferase, have been found in various nonneural tissues such as the epithelium, mesothelium, endothelium, muscle,
immune cells and blood cells. The widespread expression of nonneuronal acetylcholine is accompanied by the ubiquitous presence of acetylcholinesterase and nicotinic/muscarinic
receptors. Structural and functional dissimilarities are evident between the nonneuronal and neuronal cholinergic
systems. An increasing body of evidence
throughout the last few years has placed acetylcholine as a major cellular signaling molecule in many pathways. Furthermore,
numerous erythrocyte physiological events in the microcirculation are strongly regulated by acetylcholine.
Thus, it is time to revise our understanding of the role of vascular acetylcholine in humans. Its biological and pathobiological roles must be evaluated in more detail to
eventually achieve novel therapeutical targets. The present article reviews recent findings about nonneuronal acetylcholine
in red blood cells, with special regard to (1) red cell rheology, (2) plasma ion concentrations, (3) nitric oxide
intracellular translocation and metabolism and (4) band 3 protein phosphorylation
Sex-specific differences in prevalence and in the factors associated to the search for health services in a population based epidemiological study
Fatores contextuais e individuais associados Ă hipertensĂŁo arterial entre idosos brasileiros (Pesquisa Nacional de SaĂşde - 2013)
Biogeography of New World Tarantulas
Biogeography is a multidisciplinary field that is concerned with delimit- ing and explaining the geographic distributions of organisms in space and time. Due to their distribution patterns and interesting biology (e.g., ancient lineage with a nearly cosmopolitan distribution, sedentary lifestyle with limited dispersal capabili- ties), tarantulas are an appealing taxonomic group for addressing a variety of bio- geographic questions concerning the Earth’s history. In this chapter, we discuss some biogeographic basic concepts, delve into the distribution patterns of New World tarantulas, and explore some of the historical explanations that may have led to these distributions. We mostly review and highlight the results of recent studies but also include personal observations and unpublished data. The distributions of higher-level taxonomic groups (subfamilies and tribes) are described and we detail their latitudinal and elevational limits. We also review the distributions of groups with unique insular habitats such as those found on islands surrounded by seas, forested “islands” surrounded by “seas” of deserts, and caves. Furthermore, we dis- cuss the distribution of some unique morphological characters of taxonomic impor- tance such as urticating setae. Finally, we review a handful of studies that have explicitly investigated the biogeography of New World tarantulas using a variety of different analytical methods.Fil: Perafán, Carlos. Universidad de la RepĂşblica. Facultad de Ciencias; UruguayFil: Ferretti, Nelson Edgardo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - BahĂa Blanca. Instituto de Ciencias BiolĂłgicas y BiomĂ©dicas del Sur. Universidad Nacional del Sur. Departamento de BiologĂa, BioquĂmica y Farmacia. Instituto de Ciencias BiolĂłgicas y BiomĂ©dicas del Sur; ArgentinaFil: Hendrixson, Brent E.. Millsaps College. Department Of Biology; Estados Unido