Physical activity attenuates metabolic risk of adolescents with overweight or obesity: the ICAD multi-country study.

BACKGROUND: Although the benefits of physical activity (PA) at an early age are well established, there is no robust evidence of the role of PA as well as its intensities in attenuating the association between weight status and metabolic risk among adolescents. In this investigation, we analyzed the association between weight status, intensities of PA, and metabolic risk among adolescents. METHODS: Data from six cross-sectional studies in the International Children's Accelerometry Database were used (N = 5216 adolescents; boys 14.6 ± 2.1 years and girls 14.7 ± 2.0 years). Weight status was assessed and classified according to body mass index. Fasting glucose, triglycerides, inverse high-density lipoprotein cholesterol, and blood pressure composed the metabolic risk indicator (z-score). PA was measured by accelerometers. The estimated age of peak height velocity was used as a covariate for somatic maturation. RESULTS: We observed that increase in weight status showed a strong positive relationship with metabolic risk. However, adolescents with overweight or obesity in the highest tertile of PA (moderate-to-vigorous and vigorous intensity) showed a similar metabolic risk score as the normal weight groups. Moderate intensity PA seemed related to metabolic risk even within some categories of vigorous PA. CONCLUSIONS: We conclude that PA attenuates the metabolic risk of adolescents with overweight or obesity. Although this attenuation is largely explained by vigorous PA, moderate intensity seems also important for better metabolic profile.Dr. E.M.F. van Sluijs, MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (Sport, Physical activity and Eating behavior: Environmental Determinants in Young people [SPEEDY]). The UK Medical Research Council and the Wellcome Trust (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC

Isoresponse Versus Isoinput Estimates of Cochlear Filter Tuning

The tuning of a linear filter may be inferred from the filter’s isoresponse (e.g., tuning curves) or isoinput (e.g., isolevel curves) characteristics. This paper provides a theoretical demonstration that for nonlinear filters with compressive response characteristics like those of the basilar membrane, isoresponse measures can suggest strikingly sharper tuning than isoinput measures. The practical significance of this phenomenon is demonstrated by inferring the 3-dB-down bandwidths (BW3dB) of human auditory filters at 500 and 4,000 Hz from behavioral isoresponse and isoinput measures obtained with sinusoidal and notched noise forward maskers. Inferred cochlear responses were compressive for the two types of maskers. Consistent with expectations, low-level BW3dB estimates obtained from isoresponse conditions were considerably narrower than those obtained from isolevel conditions: 69 vs. 174 Hz, respectively, at 500 Hz, and 280 vs. 464 Hz, respectively, at 4,000 Hz. Furthermore, isoresponse BW3dB decreased with increasing level while corresponding isolevel estimates remained approximately constant at 500 Hz or increased slightly at 4 kHz. It is suggested that comparisons between isoresponse supra-threshold human tuning and threshold animal neural tuning should be made with caution