Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p = 0.02), and 20 weeks (p = 0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment

Equine dietary supplements:an insight into their use and perceptions in the Irish equine industry

Background: Nutritional supplements are frequently used by horse owners/caregivers to supplement their horse(s) diets. Some work has been done to identify the types of supplements fed and the reasons for doing so; however, this has been predominantly disciple-specific and with little focus on participants’ perceptions of supplement testing and regulation. The aim of this study was to gain an insight into the use and perceptions of equine dietary supplements in the Irish equestrian industry. Methods: An online survey was designed to ascertain the following information: demographics, types of supplements fed and reasons for use, factors that influenced respondents’ choice of supplement, where advice was sought and perceptions of testing and regulation of equine supplements Results: The survey yielded 134 responses, 70% non-professionals and 30% professionals. A greater percentage of professionals included supplements in their horse(s) diets (98%) compared to non-professionals (86%). Almost 70% of professionals fed more than two supplements, whereas 80% of non-professionals reported to feed only one supplement. Joint supplements were most commonly fed by all respondents (22%) followed by calming supplements (13%). The enhancement of performance (35%) and prevention of joint disorders (34%) were the most common reasons reported by respondents for using a supplement. Over 53% of respondents sought advice on choosing a supplement from their feed merchant, followed by their veterinarian (46%). Veterinary recommendation was given as the most influential factor when choosing a supplement by 90% of respondents, followed by cost (69%). Most (93%) respondents thought that feed supplements had to meet legal standards, with each batch analysed for quality (72%) and the supplement tested on horses before being launched on to the market (92%). Conclusion: This study has identified the main types of supplements used in the Irish equestrian industry along with the reasons for their use. However, it has also highlighted major misperceptions in how supplements are tested before being launched for sale and further work on this aspect of the findings would be beneficial

Avaliação isocinética no joelho do atleta Isokinetic evaluation of athletes' knee

A avaliação isocinética tem sido usada nas últimas três décadas como método para se determinar o padrão funcional da força e do equilíbrio muscular. No nosso meio cresceu nos últimos 10 anos. É possível quantificar valores absolutos do torque, do trabalho e da potência de grupos musculares, bem como valores relativos, ou seja, da proporção agonista/antagonista de tais grupos. Outro recurso valioso consiste como método auxiliar na reabilitação das lesões esportivas. O exame é realizado com velocidade angular constante e predeterminada, seja lenta, intermediária e/ou rápida. O joelho é a articulação em que se observa maior aplicação e estudos isocinéticos. Na prática esportiva, temos por um lado a importância da proporção do equilíbrio muscular agonista/antagonista, ou seja, do equilíbrio flexor/extensor representado, respectivamente, pelos isquiotibiais/quadríceps. De outro, a comparação dos valores absolutos da função muscular entre os lados direito e esquerdo, quer seja para o quadríceps, ou para os isquiotibiais. Resultados alterados estão relacionados, geralmente, às lesões esportivas ou suas seqüelas. De interesse para o atleta e para a equipe multidisciplinar é poder dispor de um método de avaliação funcional muscular objetivo e seguro, que forneça dados confiáveis e reprodutíveis. Aspecto relevante reside no fato do resultado do teste isocinético poder ser útil nos critérios de retorno a atividade esportiva pós-lesão. Este artigo de revisão consiste em abordar alguns aspectos práticos da avaliação isocinética no joelho e sua utilização para os indivíduos que realizam atividade física.<br>The isokinetic evaluation has been used in the last three decades as a method to determine both the strength functional pattern and the muscle balance. In our environment, this evaluation has been spread over the last 10 years. It is possible to quantify absolute values of torque, effort, and power of muscle groups, and to determine relative values, that is, the agonist/antagonist proportion of such groups. Another valuable resource of this evaluation may be used as an auxiliary method in the rehabilitation of sports lesions. The examination is performed with a constant and preset angular speed, that is, low, intermediate, and/or high speed. Most isokinetic studies are applied to the knee. In the sports practice, the agonist/antagonist muscle balance, that is, the flexor/extensor balance represented, respectively, by the ischiotibial muscle/quadriceps plays an important role. On the other hand, the comparison between the absolute values of the muscle function for the left and right sides is also relevant. Changed results usually relate to sports lesions or their sequels. The development of an objective and safe method to evaluate the muscle functionality which provides for reliable and reproducible results is of utmost importance to athletes and to multidisciplinary teams. Also significant are the results obtained from isokinetic tests, which may be useful to establish criteria for athletes to resume and practice sports activities after lesions. This review aims at addressing some practical aspects of the isokinetic evaluation in the knee and its use in individuals performing sports activities

Complex Modulation of Rapidly Rotating Young M Dwarfs: Adding Pieces to the Puzzle

New sets of young M dwarfs with complex, sharp-peaked, and strictly periodic photometric modulations have recently been discovered with Kepler/K2 (scallop shells) and TESS (complex rotators). All are part of star-forming associations, are distinct from other variable stars, and likely belong to a unified class. Suggested hypotheses include star spots, accreting dust disks, co-rotating clouds of material, magnetically constrained material, spots and misaligned disks, and pulsations. Here, we provide a comprehensive overview and add new observational constraints with TESS and SPECULOOS Southern Observatory (SSO) photometry. We scrutinize all hypotheses from three new angles: (1) we investigate each scenario's occurrence rates via young star catalogs; (2) we study the features' longevity using over one year of combined data; and (3) we probe the expected color dependency with multi-color photometry. In this process, we also revisit the stellar parameters accounting for activity effects, study stellar flares as activity indicators over year-long time scales, and develop toy models to simulate typical morphologies. We rule out most hypotheses, and only (i) co-rotating material clouds and (ii) spots and misaligned disks remain feasible - with caveats. For (i), co-rotating dust might not be stable enough, while co-rotating gas alone likely cannot cause percentage-scale features; and (ii) would require misaligned disks around most young M dwarfs. We thus suggest a unified hypothesis, a superposition of large-amplitude spot modulations and sharp transits of co-rotating gas clouds. While the complex rotators' mystery remains, these new observations add valuable pieces to the puzzle going forward