23 research outputs found
The impact of interactive courses on medical students compared to the traditional coruses. An prospective, observational study
A new solution in cartilage repair surgery of joint lesions
OBJECTIVES AND BACKGROUND
The purpose of this study is to provide a simple,
cost-effective, reproducible technology that is able to
regenerate durable hyaline cartilage. Traumas and sports
along with different diseases such as obesity or gradual
degeneration over time of the joint surface determine
cartilage defects resulting in pain and dysfunctionality.
MATERIALS AND METHODS
Since 2011 a number of 183 pacients were treated
using Agili-C, out of which 40 pacients were operated in
the IInd Clinic of Orthopaedics of the Timișoara
Emergency County Hospital. The implant is a biphasic,
porous, resorbable tissue regeneration scaffold used in the
treatment of osteochondral defects. The surgical
procedure is performed through minimal arthrotomy,
with a good exposure of the cartilage defect. The implant
is inserted so that the articular surface of the implant is
parallel with the surrounding healthy cartilage. When in
place, it facilitates vascularization thus allowing tissue
formation to commence from the periphery towards the
center of the defect.
RESULTS
Until now, results are promising, showing obvious
improvements in pain and function in both degenerative
and post-traumatic joint lesions in the knee, ankle and
first MP joint.
CONCLUSIONS
Agili-C is a cell free, single stage, off the shelf
implant that will hopefully meet market demands and
become a reliable procedure in joint repair surgery in the
future.
Figure 1: Intra-operative aspect after the
implant is in place.
REFERENCES
1. Mehdi Kazemzadeh-Narbat et al.
Biomaterials.2010. p.31.
2. Scaglione et al. Tissue engineering: Part A.
2009;15:1.
FOOTNOTE
Agili-C is a product of CartiHeal Compan
Osteochondral Regeneration with a Scaffold-Free Three-Dimensional Construct of Adipose Tissue-Derived Mesenchymal Stromal Cells in Pigs
The effect of chip breaker geometry on chip shape, bending moment, and cutting force: FE analysis and experimental study
Deep vein thrombosis following the treatment of lower limb pathologic bone fractures – a comparative study
Suitability of old apple varieties in organic farming, based on their resistance against apple scab and powdery mildew
Initial Boost Release of Transforming Growth Factor-β3 and Chondrogenesis by Freeze-Dried Bioactive Polymer Scaffolds
Repair and tissue engineering techniques for articular cartilage
Chondral and osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis, eventually leading to progressive total joint destruction. Although current progress suggests that biologic agents can delay the advancement of deterioration, such drugs are incapable of promoting tissue restoration. The limited ability of articular cartilage to regenerate renders joint arthroplasty an unavoidable surgical intervention. This Review describes current, widely used clinical repair techniques for resurfacing articular cartilage defects; short-term and long-term clinical outcomes of these techniques are discussed. Also reviewed is a developmental pipeline of acellular and cellular regenerative products and techniques that could revolutionize joint care over the next decade by promoting the development of functional articular cartilage. Acellular products typically consist of collagen or hyaluronic-acid-based materials, whereas cellular techniques use either primary cells or stem cells, with or without scaffolds. Central to these efforts is the prominent role that tissue engineering has in translating biological technology into clinical products; therefore, concomitant regulatory processes are also discussed